Investigation of the potential interaction between terfenadine and tedisamil in human liver microsomes

S McCully, G A Cameron, G M Hawksworth, A Bader, J T Borlak

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

1. The potential drug-drug interaction of terfenadine and tedisamil has been investigated. Terfenadine is a widely used antihistamine drug with the potential for QTC prolongation. Tedisamil is a potassium channel blocking agent known to produce bradycardia and prolong the effective refractory period in man. 2. Tedisamil and terfenadine were incubated with human liver microsomes for 30 min at 37 degrees C. No significant inhibition of terfenadine biotransformation was seen with 0.1 or 10 microM tedisamil as the formation of the terfenadine alcohol and acid metabolites were unaffected. 3. Based on the in vitro results it is suggested that tedisamil will not interact pharmacokinetically with terfenadine as it does not impair metabolism of terfenadine.

Original languageEnglish
Pages (from-to)219-23
Number of pages5
JournalXenobiotica
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 1998

Fingerprint

Terfenadine
Liver Microsomes
Liver
Drug interactions
Histamine Antagonists
Potassium Channels
Bradycardia
Biotransformation
Metabolites
tedisamil
Drug Interactions
Metabolism
Pharmaceutical Preparations
Refractory materials
Alcohols
Acids

Keywords

  • Adult
  • Aged
  • Bicyclo Compounds, Heterocyclic
  • Cardiotonic Agents
  • Cyclopropanes
  • Drug Interactions
  • Female
  • Histamine H1 Antagonists
  • Humans
  • Male
  • Microsomes, Liver
  • Middle Aged
  • Terfenadine

Cite this

McCully, S., Cameron, G. A., Hawksworth, G. M., Bader, A., & Borlak, J. T. (1998). Investigation of the potential interaction between terfenadine and tedisamil in human liver microsomes. Xenobiotica, 28(3), 219-23. https://doi.org/10.1080/004982598239524

Investigation of the potential interaction between terfenadine and tedisamil in human liver microsomes. / McCully, S; Cameron, G A; Hawksworth, G M; Bader, A; Borlak, J T.

In: Xenobiotica, Vol. 28, No. 3, 03.1998, p. 219-23.

Research output: Contribution to journalArticle

McCully, S, Cameron, GA, Hawksworth, GM, Bader, A & Borlak, JT 1998, 'Investigation of the potential interaction between terfenadine and tedisamil in human liver microsomes', Xenobiotica, vol. 28, no. 3, pp. 219-23. https://doi.org/10.1080/004982598239524
McCully, S ; Cameron, G A ; Hawksworth, G M ; Bader, A ; Borlak, J T. / Investigation of the potential interaction between terfenadine and tedisamil in human liver microsomes. In: Xenobiotica. 1998 ; Vol. 28, No. 3. pp. 219-23.
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