Iodine deficiency in cattle: compensatory changes in thyroidal selenoenzymes

P Zagrodzki, Fergus Nicol, M A McCoy, J A Smyth, D G Kennedy, G J Beckett, John Arthur

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Abstract

The trace elements selenium and iodine are both essential for normal thyroid hormone metabolism. To investigate the relationships between these functions, heifers were maintained on iodine-deficient or iodine-sufficient diets from mid pregnancy to term. in these heifers and their offspring the interrelationship between iodine and selenium was apparent with the preferential 10- to 12-fold induction of the selenoenzyme, thyroidal type I, selenium-containing iodothyronine deiodinase activity by iodine deficiency. This was accompanied by two- to four-fold increases in cytosolic glutathione peroxidase activity, probably reflecting increased oxidative activity and metabolism in the thyroid gland in response to iodine deficiency. The above selenoenzyme activities were not affected in liver, kidney, pituitary and brain by iodine deficiency. The results are consistent with a critical role for selenium in both the normal function of cattle thyroid and key enzymes to compensate for the effects of iodine deficiency.

Original languageEnglish
Pages (from-to)209-211
Number of pages3
JournalResearch in Veterinary Science
Volume64
Issue number3
Publication statusPublished - 1998

Keywords

  • I IODOTHYRONINE DEIODINASE
  • SELENIUM DEFICIENCY
  • HORMONE METABOLISM
  • SELENOPROTEIN
  • SUPPLEMENTATION
  • EXPRESSION
  • CALVES
  • GLAND
  • RATS

Cite this

Zagrodzki, P., Nicol, F., McCoy, M. A., Smyth, J. A., Kennedy, D. G., Beckett, G. J., & Arthur, J. (1998). Iodine deficiency in cattle: compensatory changes in thyroidal selenoenzymes. Research in Veterinary Science, 64(3), 209-211.