Iron and copper in fetal development

Lorraine Gambling, Christine Kennedy, Harry J. McArdle

Research output: Contribution to journalLiterature review

37 Citations (Scopus)

Abstract

Copper and iron are both essential micronutrients. Because they can both accept and donate electrons, they are central to many energy dependent chemical reactions. For example, copper is a critical part of ferroxidase enzymes ceruloplasmin, hephaestin and zyklopen, as well as enzymes such as dopamine-ß-monoxygenase, while iron is part of the catalytic site of many cytochromes and enzymes involved in fatty acid desaturation. Unsurprisingly, therefore, copper and iron deficiency, especially during pregnancy, when cell proliferation and differentiation are very active, sub-optimal nutrient status can lead to serious consequences. These problems can persist into adulthood, with an increased risk of mental problems such as schizophrenia and, in animal models at least, hypertension and obesity. In this review, we consider what these problems are and how they may arise. We examine the role of copper and iron deficiencies separately during fetal development, in terms of birth outcome and then how problems with status in utero can have long term sequelae for the offspring. We examine several possible mechanisms of action, both direct and indirect. Direct causes include, for example, reduced enzyme activity, while indirect ones may result from changes in cytokine activity, reductions in cell number or increased apoptosis, to name but a few. We examine a very important area of nutrition-interactions between the micronutrients and conclude that, while we have made significant advances in understanding the relationship between micronutrient status and pregnancy outcome, there is still much to be learned.
Original languageEnglish
Pages (from-to)637-644
Number of pages8
JournalSeminars in Cell & Developmental Biology
Volume22
Issue number6
DOIs
Publication statusPublished - Aug 2011

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Fetal Development
Copper
Micronutrients
Iron
Enzymes
Term Birth
Ceruloplasmin
Cytochromes
Pregnancy Outcome
Cell Differentiation
Dopamine
Catalytic Domain
Schizophrenia
Fatty Acids
Animal Models
Obesity
Cell Count
Cell Proliferation
Electrons
Apoptosis

Keywords

  • iron
  • copper
  • deficiency
  • pregnancy

Cite this

Iron and copper in fetal development. / Gambling, Lorraine; Kennedy, Christine; McArdle, Harry J.

In: Seminars in Cell & Developmental Biology, Vol. 22, No. 6, 08.2011, p. 637-644.

Research output: Contribution to journalLiterature review

Gambling, Lorraine ; Kennedy, Christine ; McArdle, Harry J. / Iron and copper in fetal development. In: Seminars in Cell & Developmental Biology. 2011 ; Vol. 22, No. 6. pp. 637-644.
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