Iron, copper and fetal development

Lorraine Gambling, Harry J McArdle

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Pregnancy is a period of rapid growth and cell differentiation for both the mother and fetus. Consequently, it is a period when both are vulnerable to changes in dietary supply, especially of those nutrients that are marginal under normal circumstances. In developed countries this vulnerability applies mainly to micronutrients. Even now, Fe deficiency is a common disorder, especially in pregnancy. Similarly, Cu intake in the UK population is rarely above adequate levels, which is a matter of some concern, both in terms of public health and possible clinical consequences. In early studies it was shown that lambs born to mothers on Cu-deficient pastures develop 'swayback,' with neurological and muscular symptoms that cannot be reversed by postnatal supplementation. More recently, rat studies have shown that responses such as the 'startle' response are lost in offspring of Cu-deficient mothers. Data have shown that prenatal Fe deficiency results in increased postnatal blood pressure, even though the offspring have normal dietary Fe levels from birth. These observations emphasise the importance of Fe and Cu in growth and development. In the present review the importance of these metals and the consequences, both short term and long term, of deficiency will be discussed and some possible mechanisms whereby these effects may be generated will be considered.

Original languageEnglish
Pages (from-to)553-562
Number of pages10
JournalProceedings of the Nutrition Society
Volume63
Issue number4
DOIs
Publication statusPublished - Nov 2004

Keywords

  • iron
  • copper
  • pregnancy
  • blood-pressure
  • deficient rats
  • glucose-tolerance
  • maternal anemia
  • cardiovascular-disease
  • cytochrome-oxidase
  • diabetic mothers
  • placental weight
  • dietary
  • pregant - women

Cite this

Iron, copper and fetal development. / Gambling, Lorraine; McArdle, Harry J.

In: Proceedings of the Nutrition Society, Vol. 63, No. 4, 11.2004, p. 553-562.

Research output: Contribution to journalArticle

Gambling, Lorraine ; McArdle, Harry J. / Iron, copper and fetal development. In: Proceedings of the Nutrition Society. 2004 ; Vol. 63, No. 4. pp. 553-562.
@article{cc75049f08b045ba9d7df1b1fe8fd6e8,
title = "Iron, copper and fetal development",
abstract = "Pregnancy is a period of rapid growth and cell differentiation for both the mother and fetus. Consequently, it is a period when both are vulnerable to changes in dietary supply, especially of those nutrients that are marginal under normal circumstances. In developed countries this vulnerability applies mainly to micronutrients. Even now, Fe deficiency is a common disorder, especially in pregnancy. Similarly, Cu intake in the UK population is rarely above adequate levels, which is a matter of some concern, both in terms of public health and possible clinical consequences. In early studies it was shown that lambs born to mothers on Cu-deficient pastures develop 'swayback,' with neurological and muscular symptoms that cannot be reversed by postnatal supplementation. More recently, rat studies have shown that responses such as the 'startle' response are lost in offspring of Cu-deficient mothers. Data have shown that prenatal Fe deficiency results in increased postnatal blood pressure, even though the offspring have normal dietary Fe levels from birth. These observations emphasise the importance of Fe and Cu in growth and development. In the present review the importance of these metals and the consequences, both short term and long term, of deficiency will be discussed and some possible mechanisms whereby these effects may be generated will be considered.",
keywords = "iron, copper, pregnancy, blood-pressure, deficient rats, glucose-tolerance, maternal anemia, cardiovascular-disease, cytochrome-oxidase, diabetic mothers, placental weight, dietary , pregant - women",
author = "Lorraine Gambling and McArdle, {Harry J}",
year = "2004",
month = "11",
doi = "10.1079/PNS2004385",
language = "English",
volume = "63",
pages = "553--562",
journal = "Proceedings of the Nutrition Society",
issn = "0029-6651",
publisher = "Cambridge Univ. Press.",
number = "4",

}

TY - JOUR

T1 - Iron, copper and fetal development

AU - Gambling, Lorraine

AU - McArdle, Harry J

PY - 2004/11

Y1 - 2004/11

N2 - Pregnancy is a period of rapid growth and cell differentiation for both the mother and fetus. Consequently, it is a period when both are vulnerable to changes in dietary supply, especially of those nutrients that are marginal under normal circumstances. In developed countries this vulnerability applies mainly to micronutrients. Even now, Fe deficiency is a common disorder, especially in pregnancy. Similarly, Cu intake in the UK population is rarely above adequate levels, which is a matter of some concern, both in terms of public health and possible clinical consequences. In early studies it was shown that lambs born to mothers on Cu-deficient pastures develop 'swayback,' with neurological and muscular symptoms that cannot be reversed by postnatal supplementation. More recently, rat studies have shown that responses such as the 'startle' response are lost in offspring of Cu-deficient mothers. Data have shown that prenatal Fe deficiency results in increased postnatal blood pressure, even though the offspring have normal dietary Fe levels from birth. These observations emphasise the importance of Fe and Cu in growth and development. In the present review the importance of these metals and the consequences, both short term and long term, of deficiency will be discussed and some possible mechanisms whereby these effects may be generated will be considered.

AB - Pregnancy is a period of rapid growth and cell differentiation for both the mother and fetus. Consequently, it is a period when both are vulnerable to changes in dietary supply, especially of those nutrients that are marginal under normal circumstances. In developed countries this vulnerability applies mainly to micronutrients. Even now, Fe deficiency is a common disorder, especially in pregnancy. Similarly, Cu intake in the UK population is rarely above adequate levels, which is a matter of some concern, both in terms of public health and possible clinical consequences. In early studies it was shown that lambs born to mothers on Cu-deficient pastures develop 'swayback,' with neurological and muscular symptoms that cannot be reversed by postnatal supplementation. More recently, rat studies have shown that responses such as the 'startle' response are lost in offspring of Cu-deficient mothers. Data have shown that prenatal Fe deficiency results in increased postnatal blood pressure, even though the offspring have normal dietary Fe levels from birth. These observations emphasise the importance of Fe and Cu in growth and development. In the present review the importance of these metals and the consequences, both short term and long term, of deficiency will be discussed and some possible mechanisms whereby these effects may be generated will be considered.

KW - iron

KW - copper

KW - pregnancy

KW - blood-pressure

KW - deficient rats

KW - glucose-tolerance

KW - maternal anemia

KW - cardiovascular-disease

KW - cytochrome-oxidase

KW - diabetic mothers

KW - placental weight

KW - dietary

KW - pregant - women

U2 - 10.1079/PNS2004385

DO - 10.1079/PNS2004385

M3 - Article

VL - 63

SP - 553

EP - 562

JO - Proceedings of the Nutrition Society

JF - Proceedings of the Nutrition Society

SN - 0029-6651

IS - 4

ER -