Abstract
Objective: To assess the association between asymptomatic bacteriuria (ASB) and short cervical length (CL), since they are both associated with preterm delivery. Study design: In two prospective multicentre cohort studies, pregnant women were screened for the presence of ASB and short CL (≤25 mm). We compared CL in women with and without ASB. Both studies had a small randomised clinical trial embedded. Results: Our study population comprised 1 610 women, of whom 114 were ASB positive. Median cervical length was similar in women with and without ASB (44.0 vs 44.0 mm, P = 0.60). More women in the ASB positive group had a short CL compared to the ASB negative group (1.8 % versus 0.4 %, P = 0.047)). The gestational age at delivery did not differ between the groups (ranging from 38 + 3 in women with ASB and short CL to 39 + 5 in women without ASB with a short CL P = 0.52). No preterm births occurred in women with a short cervical length (regardless of ASB status). In the women without ASB and no short CL 4.8 % had a preterm birth, in the women with ASB but not a short CL 4.1 % had a preterm birth. Conclusion: While ASB status did not influence median cervical length, we found a significant relationship between a short CL and ASB positive women. We found no statistical significant difference on the preterm birth rate and mean gestational age.
Original language | English |
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Pages (from-to) | 172-176 |
Number of pages | 5 |
Journal | European Journal of Obstetrics and Gynecology and Reproductive Biology |
Volume | 248 |
Early online date | 12 Mar 2020 |
DOIs | |
Publication status | Published - May 2020 |
Bibliographical note
These studies were funded by ZonMw, the Netherlands Organisation for Health Research and Development, grant number 50-50110-96-530. We thank all women who participated in this trial; the staff, research nurses, and midwifes of the Academic Medical Centre, VU Medical Centre, VCO Ultrasound Centre, MaMa Ultrasound Centre, Maxima Medical Centre, Atrium Medical Centre, Radboud University Medical Centre, Espérance Ultrasound Centre, Fara Ultrasound Centre, Diakonessenhuis Utrecht, University Medical Centre Utrecht, EVA Ultrasound Centre, and Slingeland Hospital for their contributions to this study; and the Perinatal Registry Netherlands for use of the database for this study.Keywords
- ASB
- Asymptomatic bacteriuria
- Cervical length
- Pregnancy
- Prenatal care
- URINARY-TRACT-INFECTIONS
- PRETERM BIRTH
- RISK
- TRENDS
- DELIVERY