Is chronic pain associated with subsequent cancer? A cohort record linkage study

Alison M Elliott, Nicola Torrance, Blair H Smith, Amanda J Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)
3 Downloads (Pure)

Abstract

A previous study has reported that chronic pain is associated with a higher incidence of overall and site-specific cancer in subsequent years. The aim of this study was to confirm or refute these findings. In 1996, a cohort of 6940 individuals was recruited, and information on chronic pain, general health and socio-demographic details collected. Ten years later, a record linkage study was conducted between these data and the routinely collected national dataset for cancer registration. Hazard ratios for the incidence of all cancers and eight cancer-specific sites by chronic pain status were calculated. Eighty-four percent of individuals from the original cohort were linked. After excluding those with a known previous cancer diagnosis, all non-melanoma skin cancers and cancers which were not first occurrences, a total of 646 cancers had occurred in 607 people since the baseline study. The overall cancer incidence in the cohort was 10.4% over the 10 years. There were no significant associations between chronic pain and all cancer, or any of the eight cancer-specific sites, after adjustment for age and sex. There was a significant increased risk of developing lymphoma/leukaemia amongst those with all chronic pain and various causes of chronic pain on univariate analysis. After adjustment, these trends remained, although most of the associations were no longer significant. There were no significant differences between those with severe chronic pain compared to those with mild chronic pain. The findings suggest that those with chronic pain are not at a significantly increased risk of developing cancer.
Original languageEnglish
Pages (from-to)860-863
Number of pages4
JournalEuropean Journal of Pain
Volume14
Issue number8
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Chronic Pain
Neoplasms
Incidence
Skin Neoplasms
Lymphoma
Leukemia
Demography
Health

Keywords

  • pain
  • chronic pain
  • cancer
  • cohort study
  • record Linkage

Cite this

Is chronic pain associated with subsequent cancer? A cohort record linkage study. / Elliott, Alison M; Torrance, Nicola; Smith, Blair H; Lee, Amanda J.

In: European Journal of Pain, Vol. 14, No. 8, 09.2010, p. 860-863.

Research output: Contribution to journalArticle

Elliott, Alison M ; Torrance, Nicola ; Smith, Blair H ; Lee, Amanda J. / Is chronic pain associated with subsequent cancer? A cohort record linkage study. In: European Journal of Pain. 2010 ; Vol. 14, No. 8. pp. 860-863.
@article{c94bbef2e32e4a5fa6327ff81cb0dfa4,
title = "Is chronic pain associated with subsequent cancer?: A cohort record linkage study",
abstract = "A previous study has reported that chronic pain is associated with a higher incidence of overall and site-specific cancer in subsequent years. The aim of this study was to confirm or refute these findings. In 1996, a cohort of 6940 individuals was recruited, and information on chronic pain, general health and socio-demographic details collected. Ten years later, a record linkage study was conducted between these data and the routinely collected national dataset for cancer registration. Hazard ratios for the incidence of all cancers and eight cancer-specific sites by chronic pain status were calculated. Eighty-four percent of individuals from the original cohort were linked. After excluding those with a known previous cancer diagnosis, all non-melanoma skin cancers and cancers which were not first occurrences, a total of 646 cancers had occurred in 607 people since the baseline study. The overall cancer incidence in the cohort was 10.4{\%} over the 10 years. There were no significant associations between chronic pain and all cancer, or any of the eight cancer-specific sites, after adjustment for age and sex. There was a significant increased risk of developing lymphoma/leukaemia amongst those with all chronic pain and various causes of chronic pain on univariate analysis. After adjustment, these trends remained, although most of the associations were no longer significant. There were no significant differences between those with severe chronic pain compared to those with mild chronic pain. The findings suggest that those with chronic pain are not at a significantly increased risk of developing cancer.",
keywords = "pain, chronic pain, cancer, cohort study, record Linkage",
author = "Elliott, {Alison M} and Nicola Torrance and Smith, {Blair H} and Lee, {Amanda J}",
year = "2010",
month = "9",
doi = "10.1016/j.ejpain.2010.02.001",
language = "English",
volume = "14",
pages = "860--863",
journal = "European Journal of Pain",
issn = "1090-3801",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Is chronic pain associated with subsequent cancer?

T2 - A cohort record linkage study

AU - Elliott, Alison M

AU - Torrance, Nicola

AU - Smith, Blair H

AU - Lee, Amanda J

PY - 2010/9

Y1 - 2010/9

N2 - A previous study has reported that chronic pain is associated with a higher incidence of overall and site-specific cancer in subsequent years. The aim of this study was to confirm or refute these findings. In 1996, a cohort of 6940 individuals was recruited, and information on chronic pain, general health and socio-demographic details collected. Ten years later, a record linkage study was conducted between these data and the routinely collected national dataset for cancer registration. Hazard ratios for the incidence of all cancers and eight cancer-specific sites by chronic pain status were calculated. Eighty-four percent of individuals from the original cohort were linked. After excluding those with a known previous cancer diagnosis, all non-melanoma skin cancers and cancers which were not first occurrences, a total of 646 cancers had occurred in 607 people since the baseline study. The overall cancer incidence in the cohort was 10.4% over the 10 years. There were no significant associations between chronic pain and all cancer, or any of the eight cancer-specific sites, after adjustment for age and sex. There was a significant increased risk of developing lymphoma/leukaemia amongst those with all chronic pain and various causes of chronic pain on univariate analysis. After adjustment, these trends remained, although most of the associations were no longer significant. There were no significant differences between those with severe chronic pain compared to those with mild chronic pain. The findings suggest that those with chronic pain are not at a significantly increased risk of developing cancer.

AB - A previous study has reported that chronic pain is associated with a higher incidence of overall and site-specific cancer in subsequent years. The aim of this study was to confirm or refute these findings. In 1996, a cohort of 6940 individuals was recruited, and information on chronic pain, general health and socio-demographic details collected. Ten years later, a record linkage study was conducted between these data and the routinely collected national dataset for cancer registration. Hazard ratios for the incidence of all cancers and eight cancer-specific sites by chronic pain status were calculated. Eighty-four percent of individuals from the original cohort were linked. After excluding those with a known previous cancer diagnosis, all non-melanoma skin cancers and cancers which were not first occurrences, a total of 646 cancers had occurred in 607 people since the baseline study. The overall cancer incidence in the cohort was 10.4% over the 10 years. There were no significant associations between chronic pain and all cancer, or any of the eight cancer-specific sites, after adjustment for age and sex. There was a significant increased risk of developing lymphoma/leukaemia amongst those with all chronic pain and various causes of chronic pain on univariate analysis. After adjustment, these trends remained, although most of the associations were no longer significant. There were no significant differences between those with severe chronic pain compared to those with mild chronic pain. The findings suggest that those with chronic pain are not at a significantly increased risk of developing cancer.

KW - pain

KW - chronic pain

KW - cancer

KW - cohort study

KW - record Linkage

U2 - 10.1016/j.ejpain.2010.02.001

DO - 10.1016/j.ejpain.2010.02.001

M3 - Article

VL - 14

SP - 860

EP - 863

JO - European Journal of Pain

JF - European Journal of Pain

SN - 1090-3801

IS - 8

ER -