TY - JOUR
T1 - Is conception by in-vitro fertilisation associated with altered antenatal and postnatal growth trajectories?
AU - Turner, Steve
AU - Maclean, Eilidh
AU - Dick, Smita
AU - Aucott, Lorna
AU - Maheshwari, Abha
N1 - ACKNOWLEDGEMENTS
We thank Professor Siladitya Bhattacharya for his comment and suggestions made at the very start of this project.
FUNDING
The study was funded by the FARR Institute.
PY - 2020/6/24
Y1 - 2020/6/24
N2 - Objective: To study whether the growth trajectory between first, second and third trimester, birthand five years of age differs between children born following fresh (fresh ET), frozen (FET) embryo transfer and children naturally conceived (NC).Design: Historical cohort study of children. The analysis compared cross sectional and longitudinaldifferences in measurement between individuals stratified by method of conception.Setting: North East Scotland Patients: Participants were born between 1997-2012 by NC (n=65,683), fresh ET (n=576) and FET (n=179). Data were available for method of conception, fetal, maternal and neonatal characteristics and measurements at five years.Intervention (s): NoneMain Outcome Measure(s): Size at first, second and third trimester, birth and five years.Result(s): In the longitudinal model, first trimester CRL was significantly longer after fresh ET compared to NC (mean difference 0.30 z score [95% confidence interval 0.13, 0.47] p =0.0006). Second trimester head size was larger after fresh ET (mean difference 0.37 [0.21, 0.54] p<0.001) and after FET (mean difference 0.29 [0.04, 0.53] p=0.022) compared to NC. Birth weight was lower after fresh ET conception compared to FET (mean difference 0.25 [0.09, 0.44 p=0.007]). At five years of age, children conceived by fresh ET and FET were no heavier than peers conceived by NC. Conclusion(s): Individuals conceived by IVF have significantly different antenatal growth trajectories during the first and second trimester compared to NC and differences persist at birth for weight and head size. The relevance of these different growth trajectories remains uncertain and larger prospective studies are required.
AB - Objective: To study whether the growth trajectory between first, second and third trimester, birthand five years of age differs between children born following fresh (fresh ET), frozen (FET) embryo transfer and children naturally conceived (NC).Design: Historical cohort study of children. The analysis compared cross sectional and longitudinaldifferences in measurement between individuals stratified by method of conception.Setting: North East Scotland Patients: Participants were born between 1997-2012 by NC (n=65,683), fresh ET (n=576) and FET (n=179). Data were available for method of conception, fetal, maternal and neonatal characteristics and measurements at five years.Intervention (s): NoneMain Outcome Measure(s): Size at first, second and third trimester, birth and five years.Result(s): In the longitudinal model, first trimester CRL was significantly longer after fresh ET compared to NC (mean difference 0.30 z score [95% confidence interval 0.13, 0.47] p =0.0006). Second trimester head size was larger after fresh ET (mean difference 0.37 [0.21, 0.54] p<0.001) and after FET (mean difference 0.29 [0.04, 0.53] p=0.022) compared to NC. Birth weight was lower after fresh ET conception compared to FET (mean difference 0.25 [0.09, 0.44 p=0.007]). At five years of age, children conceived by fresh ET and FET were no heavier than peers conceived by NC. Conclusion(s): Individuals conceived by IVF have significantly different antenatal growth trajectories during the first and second trimester compared to NC and differences persist at birth for weight and head size. The relevance of these different growth trajectories remains uncertain and larger prospective studies are required.
KW - in vitro fertilisation
KW - Embryo Transfer
KW - growth trajectory
KW - fetal
M3 - Article
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
ER -