Abstract
The membrane glycoprotein CD200, which has a widespread but defined distribution and a structurally similar receptor (CD200R) that transmits an inhibitory signal to cells of the hematopoetic lineage, especially myeloid cells, has been characterized. CD20OR expression is restricted predominantly to cells of the myeloid lineage indicating that this ligand/receptor pair has a specific role in controlling myeloid cell function. In addition to CD200R, several related genes have been identified. Whether these gene products also regulate immune function is controversial. CD20OR is also expressed by certain subsets of T cells and CD200 may be expressed by antigen-presenting cells, adding additional layers of complexity to the CD200/CD200R axis. Because monocytic myeloid cells provide a link between the innate and adaptive immune response, mechanisms to control their function through receptors such as CD20OR will have therapeutic potential. Regulation of immune responses is accomplished by the concerted, but opposing, activity of kinases and phosphatases, fine control often being achieved through paired receptors. In this review, we will consider whether CD20OR signaling functions within a framework of paired activating and inhibitory receptors and whether the inhibitory signal delivered has functional consequences beyond inhibition of myeloid cell proinflammatory activation.
| Original language | English |
|---|---|
| Pages (from-to) | 213-230 |
| Number of pages | 17 |
| Journal | Critical Reviews in Immunology |
| Volume | 26 |
| Issue number | 3 |
| Publication status | Published - 2006 |
Keywords
- monocyte-macrophage
- dendritic cells
- autoimmunity
- allergy
- transplantation
- EXPERIMENTAL AUTOIMMUNE UVEORETINITIS
- PLASMACYTOID DENDRITIC CELLS
- IMMUNOGLOBULIN-LIKE DOMAINS
- COLLAGEN-INDUCED ARTHRITIS
- RENAL-ALLOGRAFT SURVIVAL
- CD200 RECEPTOR
- INDOLEAMINE 2,3-DIOXYGENASE
- TRYPTOPHAN CATABOLISM
- IN-VIVO
- IMMUNOREGULATORY MOLECULES
Cite this
Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? / Minas, K.; Liversidge, Janet Mary.
In: Critical Reviews in Immunology, Vol. 26, No. 3, 2006, p. 213-230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal?
AU - Minas, K.
AU - Liversidge, Janet Mary
PY - 2006
Y1 - 2006
N2 - The membrane glycoprotein CD200, which has a widespread but defined distribution and a structurally similar receptor (CD200R) that transmits an inhibitory signal to cells of the hematopoetic lineage, especially myeloid cells, has been characterized. CD20OR expression is restricted predominantly to cells of the myeloid lineage indicating that this ligand/receptor pair has a specific role in controlling myeloid cell function. In addition to CD200R, several related genes have been identified. Whether these gene products also regulate immune function is controversial. CD20OR is also expressed by certain subsets of T cells and CD200 may be expressed by antigen-presenting cells, adding additional layers of complexity to the CD200/CD200R axis. Because monocytic myeloid cells provide a link between the innate and adaptive immune response, mechanisms to control their function through receptors such as CD20OR will have therapeutic potential. Regulation of immune responses is accomplished by the concerted, but opposing, activity of kinases and phosphatases, fine control often being achieved through paired receptors. In this review, we will consider whether CD20OR signaling functions within a framework of paired activating and inhibitory receptors and whether the inhibitory signal delivered has functional consequences beyond inhibition of myeloid cell proinflammatory activation.
AB - The membrane glycoprotein CD200, which has a widespread but defined distribution and a structurally similar receptor (CD200R) that transmits an inhibitory signal to cells of the hematopoetic lineage, especially myeloid cells, has been characterized. CD20OR expression is restricted predominantly to cells of the myeloid lineage indicating that this ligand/receptor pair has a specific role in controlling myeloid cell function. In addition to CD200R, several related genes have been identified. Whether these gene products also regulate immune function is controversial. CD20OR is also expressed by certain subsets of T cells and CD200 may be expressed by antigen-presenting cells, adding additional layers of complexity to the CD200/CD200R axis. Because monocytic myeloid cells provide a link between the innate and adaptive immune response, mechanisms to control their function through receptors such as CD20OR will have therapeutic potential. Regulation of immune responses is accomplished by the concerted, but opposing, activity of kinases and phosphatases, fine control often being achieved through paired receptors. In this review, we will consider whether CD20OR signaling functions within a framework of paired activating and inhibitory receptors and whether the inhibitory signal delivered has functional consequences beyond inhibition of myeloid cell proinflammatory activation.
KW - monocyte-macrophage
KW - dendritic cells
KW - autoimmunity
KW - allergy
KW - transplantation
KW - EXPERIMENTAL AUTOIMMUNE UVEORETINITIS
KW - PLASMACYTOID DENDRITIC CELLS
KW - IMMUNOGLOBULIN-LIKE DOMAINS
KW - COLLAGEN-INDUCED ARTHRITIS
KW - RENAL-ALLOGRAFT SURVIVAL
KW - CD200 RECEPTOR
KW - INDOLEAMINE 2,3-DIOXYGENASE
KW - TRYPTOPHAN CATABOLISM
KW - IN-VIVO
KW - IMMUNOREGULATORY MOLECULES
M3 - Article
VL - 26
SP - 213
EP - 230
JO - Critical Reviews in Immunology
JF - Critical Reviews in Immunology
SN - 1040-8401
IS - 3
ER -