Is the oral contraceptive pill associated with fracture in later life?

New evidence from the Royal College of General Practitioners Oral Contraception Study

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background
Several studies, including an earlier analysis from the Royal College of General Practitioners (RCGP) Oral Contraception Study, have suggested that ever users of oral contraceptives have an increased risk of fracture when compared with never users. In this paper, we examined a subset of women in the RCGP study living in Scotland to determine whether this risk has persisted.

Study Design
A nested case-control study was carried out using data collected prospectively for the RCGP Oral Contraception Study. Cases were women with a first ever diagnosis of fracture (n=651), age-matched to two controls (n=1302). Adjustments were made for smoking, social class and parity.

Results
There was not a significant association between ever use of oral contraception and fracture (adjusted odds ratio 1.05, 95% confidence interval 0.86–1.29), compared with never users. Neither were significant associations found between fracture and smoking, social class and parity. The findings did not vary materially with age or type of fracture.

Conclusion
Ever use of oral contraception was not associated with fracture in this study.

Original languageEnglish
Pages (from-to)40-47
Number of pages7
JournalContraception
Volume84
Issue number1
Early online date21 Jan 2011
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Oral Contraceptives
Contraception
General Practitioners
Parity
Social Class
Smoking
Social Adjustment
Scotland
Case-Control Studies
Odds Ratio
Confidence Intervals

Keywords

  • oral contraceptive pill
  • fracture
  • risk
  • bone mineral density
  • osteoporosis

Cite this

@article{063846cbda2145e1a718336794f08093,
title = "Is the oral contraceptive pill associated with fracture in later life?: New evidence from the Royal College of General Practitioners Oral Contraception Study",
abstract = "Background Several studies, including an earlier analysis from the Royal College of General Practitioners (RCGP) Oral Contraception Study, have suggested that ever users of oral contraceptives have an increased risk of fracture when compared with never users. In this paper, we examined a subset of women in the RCGP study living in Scotland to determine whether this risk has persisted. Study Design A nested case-control study was carried out using data collected prospectively for the RCGP Oral Contraception Study. Cases were women with a first ever diagnosis of fracture (n=651), age-matched to two controls (n=1302). Adjustments were made for smoking, social class and parity. Results There was not a significant association between ever use of oral contraception and fracture (adjusted odds ratio 1.05, 95{\%} confidence interval 0.86–1.29), compared with never users. Neither were significant associations found between fracture and smoking, social class and parity. The findings did not vary materially with age or type of fracture. Conclusion Ever use of oral contraception was not associated with fracture in this study.",
keywords = "oral contraceptive pill, fracture, risk , bone mineral density, osteoporosis",
author = "Sanam Memon and Lisa Iversen and Hannaford, {Philip Christopher}",
year = "2011",
month = "7",
doi = "10.1016/j.contraception.2010.11.019",
language = "English",
volume = "84",
pages = "40--47",
journal = "Contraception",
issn = "0010-7824",
publisher = "Elsevier USA",
number = "1",

}

TY - JOUR

T1 - Is the oral contraceptive pill associated with fracture in later life?

T2 - New evidence from the Royal College of General Practitioners Oral Contraception Study

AU - Memon, Sanam

AU - Iversen, Lisa

AU - Hannaford, Philip Christopher

PY - 2011/7

Y1 - 2011/7

N2 - Background Several studies, including an earlier analysis from the Royal College of General Practitioners (RCGP) Oral Contraception Study, have suggested that ever users of oral contraceptives have an increased risk of fracture when compared with never users. In this paper, we examined a subset of women in the RCGP study living in Scotland to determine whether this risk has persisted. Study Design A nested case-control study was carried out using data collected prospectively for the RCGP Oral Contraception Study. Cases were women with a first ever diagnosis of fracture (n=651), age-matched to two controls (n=1302). Adjustments were made for smoking, social class and parity. Results There was not a significant association between ever use of oral contraception and fracture (adjusted odds ratio 1.05, 95% confidence interval 0.86–1.29), compared with never users. Neither were significant associations found between fracture and smoking, social class and parity. The findings did not vary materially with age or type of fracture. Conclusion Ever use of oral contraception was not associated with fracture in this study.

AB - Background Several studies, including an earlier analysis from the Royal College of General Practitioners (RCGP) Oral Contraception Study, have suggested that ever users of oral contraceptives have an increased risk of fracture when compared with never users. In this paper, we examined a subset of women in the RCGP study living in Scotland to determine whether this risk has persisted. Study Design A nested case-control study was carried out using data collected prospectively for the RCGP Oral Contraception Study. Cases were women with a first ever diagnosis of fracture (n=651), age-matched to two controls (n=1302). Adjustments were made for smoking, social class and parity. Results There was not a significant association between ever use of oral contraception and fracture (adjusted odds ratio 1.05, 95% confidence interval 0.86–1.29), compared with never users. Neither were significant associations found between fracture and smoking, social class and parity. The findings did not vary materially with age or type of fracture. Conclusion Ever use of oral contraception was not associated with fracture in this study.

KW - oral contraceptive pill

KW - fracture

KW - risk

KW - bone mineral density

KW - osteoporosis

U2 - 10.1016/j.contraception.2010.11.019

DO - 10.1016/j.contraception.2010.11.019

M3 - Article

VL - 84

SP - 40

EP - 47

JO - Contraception

JF - Contraception

SN - 0010-7824

IS - 1

ER -