Is the predictive power of previous fractures for new spine and non-spine fractures associated with biochemical evidence of altered bone remodelling? The EPOS study

P Vergnaud, M Lunt, C Scheidt-Nave, G Poor, C Gennari, K Hoszowski, A L Vaz, D M Reid, L Benevolenskaya, S Grazio, K Weber, T Miazgowski, J J Stepan, P Masaryk, F Galan, J B Armas, R Lorenc, S Havelka, R P Cano, M Seibel & 7 others G Armbrecht, S Kaptoge, T W O'Neill, A J Silman, D Felsenberg, J Reeve, P D Delmas

Research output: Contribution to journalArticle

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Abstract

Background: In the European Prospective Osteoporosis Study (EPOS), a past spine fracture increased risk of an incident fracture 3.6-12-fold even after adjusting for BMD. We examined the possibility that biochemical marker levels were associated with this unexplained BMD-independent element of fracture risk. Methods: Each of 182 cases in EPOS of spine or non-spine fracture that occurred in 3.8 years of follow-up was matched by age, sex and study centre with two randomly assigned never-fractured controls and one case of past fracture. Analytes measured blind were: osteocalcin, bone-specific alkaline phosphatase, total alkaline phosphatase, serum creatinine, calcium, phosphate and albumin, together with the collagen cross-links degradation products serum CTS and Urine CTX. Most subjects also had bone density measured by DXA. Results: Cases who had recent fractures did not differ in marker levels from cases who had their last fracture more than 3 years previously. No statistically significant effect of recent fracture was found for any marker except osteocalcin, which was 17.6% lower in recent peripheral cases compared to unfractured controls (p<0.05) and this was independent of BMD. Conclusion: Past fracture as a risk indicator for future fracture is not strongly mediated through increased bone turnover. (C) 2002 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)121-132
Number of pages12
JournalClinica Chimica Acta
Volume322
Publication statusPublished - 2002

Keywords

  • osteoporosis
  • fractures
  • biochemical markers
  • bone turnover
  • epidemiology
  • bone densitometry
  • EUROPEAN PROSPECTIVE OSTEOPOROSIS
  • INTRACAPSULAR HIP FRACTURE
  • DISTAL FOREARM FRACTURE
  • VERTEBRAL DEFORMITY
  • I COLLAGEN
  • DEGRADATION PRODUCTS
  • POSTMENOPAUSAL WOMEN
  • CANCELLOUS BONE
  • ELDERLY WOMEN
  • RISK

Cite this

Vergnaud, P., Lunt, M., Scheidt-Nave, C., Poor, G., Gennari, C., Hoszowski, K., ... Delmas, P. D. (2002). Is the predictive power of previous fractures for new spine and non-spine fractures associated with biochemical evidence of altered bone remodelling? The EPOS study. Clinica Chimica Acta, 322, 121-132.

Is the predictive power of previous fractures for new spine and non-spine fractures associated with biochemical evidence of altered bone remodelling? The EPOS study. / Vergnaud, P ; Lunt, M ; Scheidt-Nave, C ; Poor, G ; Gennari, C ; Hoszowski, K ; Vaz, A L ; Reid, D M ; Benevolenskaya, L ; Grazio, S ; Weber, K ; Miazgowski, T ; Stepan, J J ; Masaryk, P ; Galan, F ; Armas, J B ; Lorenc, R ; Havelka, S ; Cano, R P ; Seibel, M ; Armbrecht, G ; Kaptoge, S ; O'Neill, T W ; Silman, A J ; Felsenberg, D ; Reeve, J ; Delmas, P D .

In: Clinica Chimica Acta, Vol. 322, 2002, p. 121-132.

Research output: Contribution to journalArticle

Vergnaud, P, Lunt, M, Scheidt-Nave, C, Poor, G, Gennari, C, Hoszowski, K, Vaz, AL, Reid, DM, Benevolenskaya, L, Grazio, S, Weber, K, Miazgowski, T, Stepan, JJ, Masaryk, P, Galan, F, Armas, JB, Lorenc, R, Havelka, S, Cano, RP, Seibel, M, Armbrecht, G, Kaptoge, S, O'Neill, TW, Silman, AJ, Felsenberg, D, Reeve, J & Delmas, PD 2002, 'Is the predictive power of previous fractures for new spine and non-spine fractures associated with biochemical evidence of altered bone remodelling? The EPOS study', Clinica Chimica Acta, vol. 322, pp. 121-132.
Vergnaud, P ; Lunt, M ; Scheidt-Nave, C ; Poor, G ; Gennari, C ; Hoszowski, K ; Vaz, A L ; Reid, D M ; Benevolenskaya, L ; Grazio, S ; Weber, K ; Miazgowski, T ; Stepan, J J ; Masaryk, P ; Galan, F ; Armas, J B ; Lorenc, R ; Havelka, S ; Cano, R P ; Seibel, M ; Armbrecht, G ; Kaptoge, S ; O'Neill, T W ; Silman, A J ; Felsenberg, D ; Reeve, J ; Delmas, P D . / Is the predictive power of previous fractures for new spine and non-spine fractures associated with biochemical evidence of altered bone remodelling? The EPOS study. In: Clinica Chimica Acta. 2002 ; Vol. 322. pp. 121-132.
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abstract = "Background: In the European Prospective Osteoporosis Study (EPOS), a past spine fracture increased risk of an incident fracture 3.6-12-fold even after adjusting for BMD. We examined the possibility that biochemical marker levels were associated with this unexplained BMD-independent element of fracture risk. Methods: Each of 182 cases in EPOS of spine or non-spine fracture that occurred in 3.8 years of follow-up was matched by age, sex and study centre with two randomly assigned never-fractured controls and one case of past fracture. Analytes measured blind were: osteocalcin, bone-specific alkaline phosphatase, total alkaline phosphatase, serum creatinine, calcium, phosphate and albumin, together with the collagen cross-links degradation products serum CTS and Urine CTX. Most subjects also had bone density measured by DXA. Results: Cases who had recent fractures did not differ in marker levels from cases who had their last fracture more than 3 years previously. No statistically significant effect of recent fracture was found for any marker except osteocalcin, which was 17.6{\%} lower in recent peripheral cases compared to unfractured controls (p<0.05) and this was independent of BMD. Conclusion: Past fracture as a risk indicator for future fracture is not strongly mediated through increased bone turnover. (C) 2002 Elsevier Science B.V. All rights reserved.",
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TY - JOUR

T1 - Is the predictive power of previous fractures for new spine and non-spine fractures associated with biochemical evidence of altered bone remodelling? The EPOS study

AU - Vergnaud, P

AU - Lunt, M

AU - Scheidt-Nave, C

AU - Poor, G

AU - Gennari, C

AU - Hoszowski, K

AU - Vaz, A L

AU - Reid, D M

AU - Benevolenskaya, L

AU - Grazio, S

AU - Weber, K

AU - Miazgowski, T

AU - Stepan, J J

AU - Masaryk, P

AU - Galan, F

AU - Armas, J B

AU - Lorenc, R

AU - Havelka, S

AU - Cano, R P

AU - Seibel, M

AU - Armbrecht, G

AU - Kaptoge, S

AU - O'Neill, T W

AU - Silman, A J

AU - Felsenberg, D

AU - Reeve, J

AU - Delmas, P D

PY - 2002

Y1 - 2002

N2 - Background: In the European Prospective Osteoporosis Study (EPOS), a past spine fracture increased risk of an incident fracture 3.6-12-fold even after adjusting for BMD. We examined the possibility that biochemical marker levels were associated with this unexplained BMD-independent element of fracture risk. Methods: Each of 182 cases in EPOS of spine or non-spine fracture that occurred in 3.8 years of follow-up was matched by age, sex and study centre with two randomly assigned never-fractured controls and one case of past fracture. Analytes measured blind were: osteocalcin, bone-specific alkaline phosphatase, total alkaline phosphatase, serum creatinine, calcium, phosphate and albumin, together with the collagen cross-links degradation products serum CTS and Urine CTX. Most subjects also had bone density measured by DXA. Results: Cases who had recent fractures did not differ in marker levels from cases who had their last fracture more than 3 years previously. No statistically significant effect of recent fracture was found for any marker except osteocalcin, which was 17.6% lower in recent peripheral cases compared to unfractured controls (p<0.05) and this was independent of BMD. Conclusion: Past fracture as a risk indicator for future fracture is not strongly mediated through increased bone turnover. (C) 2002 Elsevier Science B.V. All rights reserved.

AB - Background: In the European Prospective Osteoporosis Study (EPOS), a past spine fracture increased risk of an incident fracture 3.6-12-fold even after adjusting for BMD. We examined the possibility that biochemical marker levels were associated with this unexplained BMD-independent element of fracture risk. Methods: Each of 182 cases in EPOS of spine or non-spine fracture that occurred in 3.8 years of follow-up was matched by age, sex and study centre with two randomly assigned never-fractured controls and one case of past fracture. Analytes measured blind were: osteocalcin, bone-specific alkaline phosphatase, total alkaline phosphatase, serum creatinine, calcium, phosphate and albumin, together with the collagen cross-links degradation products serum CTS and Urine CTX. Most subjects also had bone density measured by DXA. Results: Cases who had recent fractures did not differ in marker levels from cases who had their last fracture more than 3 years previously. No statistically significant effect of recent fracture was found for any marker except osteocalcin, which was 17.6% lower in recent peripheral cases compared to unfractured controls (p<0.05) and this was independent of BMD. Conclusion: Past fracture as a risk indicator for future fracture is not strongly mediated through increased bone turnover. (C) 2002 Elsevier Science B.V. All rights reserved.

KW - osteoporosis

KW - fractures

KW - biochemical markers

KW - bone turnover

KW - epidemiology

KW - bone densitometry

KW - EUROPEAN PROSPECTIVE OSTEOPOROSIS

KW - INTRACAPSULAR HIP FRACTURE

KW - DISTAL FOREARM FRACTURE

KW - VERTEBRAL DEFORMITY

KW - I COLLAGEN

KW - DEGRADATION PRODUCTS

KW - POSTMENOPAUSAL WOMEN

KW - CANCELLOUS BONE

KW - ELDERLY WOMEN

KW - RISK

M3 - Article

VL - 322

SP - 121

EP - 132

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

ER -