Abstract
Growth of tumors can accelerate during the peri-operative period. Accordingly, early relapse of cancer occurs in some patients during the first two postoperative years. Temporal and biologic analyses of cancer pathophysiology suggest a link between peri-operative pathophysiological changes and acceleration of tumor growth. Understanding the role of inflammation and its consequences (i.e., immune response, growth factors, dissemination of tumor cells) could lead to define a role of anesthesiologists in reducing cancer recurrence following surgery. We argue for peri-operative pharmacological interventions to reduce cancer relapse, with a focus on non-steroidal anti-inflammatory drugs.
Original language | English |
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Pages (from-to) | 15-24 |
Number of pages | 10 |
Journal | Acta Anaesthesiologica Belgica |
Volume | 64 |
Issue number | 1 |
Publication status | Published - Mar 2013 |
Bibliographical note
AcknowledgementsThe authors would like to acknowledge Karen Retsky for her contribution to the quality of the manuscript.
Financial Support : This work was supported by the Belgian Society of Anesthesia and Resuscitation. This work was also supported by the Fondation Saint-Luc, the Departments of Anesthesiology, and the Commission du Patrimoine of the Université catholique de Louvain, St-Luc Hospital. MR is supported by grant KG 100484 from Komen Foundation for the Cure.
Keywords
- inflammation
- non-steroidal anti-inflammatory drugs
- postoperative cancer recurrence