Growth of tumors can accelerate during the peri-operative period. Accordingly, early relapse of cancer occurs in some patients during the first two postoperative years. Temporal and biologic analyses of cancer pathophysiology suggest a link between peri-operative pathophysiological changes and acceleration of tumor growth. Understanding the role of inflammation and its consequences (i.e., immune response, growth factors, dissemination of tumor cells) could lead to define a role of anesthesiologists in reducing cancer recurrence following surgery. We argue for peri-operative pharmacological interventions to reduce cancer relapse, with a focus on non-steroidal anti-inflammatory drugs.
|Number of pages||10|
|Journal||Acta Anaesthesiologica Belgica|
|Publication status||Published - Mar 2013|
- non-steroidal anti-inflammatory drugs
- postoperative cancer recurrence
Forget, P., Coulie, P. G., Retsky, M., Demicheli, R., Machiels, J-P., & De Kock, M. (2013). Is there a rationale for an anesthesiologist's role against cancer recurrence? Acta Anaesthesiologica Belgica, 64(1), 15-24.