TY - JOUR
T1 - Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis
AU - Vermey, Belinda G.
AU - Chua, Su Jen
AU - Zafarmand, Mohammad Hadi
AU - Wang, Rui
AU - Longobardi, Salvatore
AU - Cottell, Evelyn
AU - Beckers, Francois
AU - Mol, Ben W.
AU - Venetis, Christos A.
AU - D'Hooghe, Thomas
N1 - Acknowledgements
The investigators would like to thank the following authors and their contributors for providing us with the extra information of the included studies: Hariton et al., 2017, Kahraman et al., 2016, Kan et al., 2017, Kok et al., 2006, Zhou et al., 2017. We would also like to thank the anonymous peer reviewers who provided constructive feedback on the first version of the manuscript. Editorial support was provided by Steven Goodrick of inScience Communications, London, UK. This project was supported and funded by Merck KGaA.
PY - 2019/11/7
Y1 - 2019/11/7
N2 - This systematic review and meta-analysis determined the association between aspirated after ovarian stimulation and top/good quality embryos obtained in women undergoing ovarian stimulation for IVF/intracytoplasmic sperm injection (ICSI). MEDLINE, EMBASE, Scopus, CINAHL and Web of Science were searched for English-language publications on top/good-quality embryos at cleavage (day 2/3) and/or blastocyst (day 5/6) developmental stages, up to 18 November 2017. Twenty-eight studies (three prospective and 25 retrospective) reporting data on 291,752 assisted reproductive technology (ART) cycles were considered eligible. We confirmed a strong positive association between oocytes retrieved and top/good-quality day 2/3 embryos (weighted correlation coefficient [rw] = 0.791), day 5/6 embryos (rw = 0.901), metaphase II oocytes (rw = 0.988), oocytes exhibiting two pronuclei (rw = 0.987) and euploid embryos (rw = 0.851); P < 0.001 for all correlations (evaluated in subsets of the 17 studies). Data from 5657 cycles showed that the group with the most oocytes aspirated had the most top/good-quality day 2/3 embryos (pooled standardized mean differences (high [>15] versus low [<4] 1.91, 95% confidence interval [CI] 1.05–2.77, P < 0.0001; high versus medium [4–15] 1.15, 95% CI 0.74–1.55, P < 0.0001; medium versus low 1.41, 95% CI 0.79–2.03, P < 0.0001). Individual participant meta-analysis would enable accurate determination of these associations and other outcomes.
AB - This systematic review and meta-analysis determined the association between aspirated after ovarian stimulation and top/good quality embryos obtained in women undergoing ovarian stimulation for IVF/intracytoplasmic sperm injection (ICSI). MEDLINE, EMBASE, Scopus, CINAHL and Web of Science were searched for English-language publications on top/good-quality embryos at cleavage (day 2/3) and/or blastocyst (day 5/6) developmental stages, up to 18 November 2017. Twenty-eight studies (three prospective and 25 retrospective) reporting data on 291,752 assisted reproductive technology (ART) cycles were considered eligible. We confirmed a strong positive association between oocytes retrieved and top/good-quality day 2/3 embryos (weighted correlation coefficient [rw] = 0.791), day 5/6 embryos (rw = 0.901), metaphase II oocytes (rw = 0.988), oocytes exhibiting two pronuclei (rw = 0.987) and euploid embryos (rw = 0.851); P < 0.001 for all correlations (evaluated in subsets of the 17 studies). Data from 5657 cycles showed that the group with the most oocytes aspirated had the most top/good-quality day 2/3 embryos (pooled standardized mean differences (high [>15] versus low [<4] 1.91, 95% confidence interval [CI] 1.05–2.77, P < 0.0001; high versus medium [4–15] 1.15, 95% CI 0.74–1.55, P < 0.0001; medium versus low 1.41, 95% CI 0.79–2.03, P < 0.0001). Individual participant meta-analysis would enable accurate determination of these associations and other outcomes.
KW - Embryo quality
KW - Euploid
KW - Oocyte number
KW - Oocyte yield
UR - http://www.scopus.com/inward/record.url?scp=85072251717&partnerID=8YFLogxK
U2 - 10.1016/j.rbmo.2019.06.013
DO - 10.1016/j.rbmo.2019.06.013
M3 - Review article
C2 - 31540848
AN - SCOPUS:85072251717
VL - 39
SP - 751
EP - 763
JO - Reproductive Biomedicine Online
JF - Reproductive Biomedicine Online
SN - 1472-6483
IS - 5
ER -