Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

Dominik Wichner, Hamidah Idris, Wael E. Houssen, Andrew R. McEwan, Alan T. Bull, Juan A. Asenjo, Michael Goodfellow, Marcel Jaspars, Rainer Ebel, Mostafa E. Rateb

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The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.

Original languageEnglish
Pages (from-to)448-453
Number of pages6
JournalThe Journal of antibiotics
Early online date29 Jun 2016
Publication statusPublished - Apr 2017


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