ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL

Caroline Barelle (Inventor), Jonathan James William Finlay (Inventor), Alfredo Darmanin-Sheehan (Inventor)

Research output: Patent

Abstract

The present invention provides ICOSL specific antigen binding molecules which are isolated from immunized and synthetic Elasmobranchii derived libraries. In particular, the present invention relates to shark Variable New Antigen Receptor (VNAR) domains that specifically bind and neutralize the activity of human Induced Co-Stimulatory Ligand (ICOSL). The neutralizing VNAR domains are isolated from two independent sources; an immunized nurse shark library and a synthetic spiny dogfish framework fusion library. The molecules may be formulated as pharmaceutical compositions and used in medicine.
Original languageEnglish
IPCC07K16/00; C07K16/18; C12N15/13
Priority date23/04/13
Publication statusPublished - 30 Oct 2014

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Antigen Receptors
Libraries
Sharks
Ligands
Squalus acanthias
Elasmobranchii
Human Activities
Therapeutics
Nurses
Medicine
Antigens
Pharmaceutical Preparations

Cite this

Barelle, C., Finlay, J. J. W., & Darmanin-Sheehan, A. (2014). IPC No. C07K16/00; C07K16/18; C12N15/13. ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL.

ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL. / Barelle, Caroline (Inventor); Finlay, Jonathan James William (Inventor); Darmanin-Sheehan, Alfredo (Inventor).

IPC No.: C07K16/00; C07K16/18; C12N15/13.

Research output: Patent

Barelle, C, Finlay, JJW & Darmanin-Sheehan, A 2014, ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL, IPC No. C07K16/00; C07K16/18; C12N15/13.
Barelle C, Finlay JJW, Darmanin-Sheehan A, inventors. ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL. C07K16/00; C07K16/18; C12N15/13. 2014 Oct 30.
Barelle, Caroline (Inventor) ; Finlay, Jonathan James William (Inventor) ; Darmanin-Sheehan, Alfredo (Inventor). / ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL. IPC No.: C07K16/00; C07K16/18; C12N15/13.
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