ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL

Caroline Barelle; Jonathan James William Finlay; Alfredo Darmanin-Sheehan

ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL

Caroline Barelle (Inventor), Jonathan James William Finlay (Inventor), Alfredo Darmanin-Sheehan (Inventor)

Medical Sciences

Research output: Patent

Abstract

The present invention provides ICOSL specific antigen binding molecules which are isolated from immunized and synthetic Elasmobranchii derived libraries. In particular, the present invention relates to shark Variable New Antigen Receptor (VNAR) domains that specifically bind and neutralize the activity of human Induced Co-Stimulatory Ligand (ICOSL). The neutralizing VNAR domains are isolated from two independent sources; an immunized nurse shark library and a synthetic spiny dogfish framework fusion library. The molecules may be formulated as pharmaceutical compositions and used in medicine.

Original language	English
IPC	C07K16/00; C07K16/18; C12N15/13
Priority date	23/04/13
Publication status	Published - 30 Oct 2014

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title = "ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL",

abstract = "The present invention provides ICOSL specific antigen binding molecules which are isolated from immunized and synthetic Elasmobranchii derived libraries. In particular, the present invention relates to shark Variable New Antigen Receptor (VNAR) domains that specifically bind and neutralize the activity of human Induced Co-Stimulatory Ligand (ICOSL). The neutralizing VNAR domains are isolated from two independent sources; an immunized nurse shark library and a synthetic spiny dogfish framework fusion library. The molecules may be formulated as pharmaceutical compositions and used in medicine.",

author = "Caroline Barelle and Finlay, {Jonathan James William} and Alfredo Darmanin-Sheehan",

year = "2014",

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type = "Patent",

note = "C07K16/00; C07K16/18; C12N15/13",

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AU - Barelle, Caroline

AU - Finlay, Jonathan James William

AU - Darmanin-Sheehan, Alfredo

PY - 2014/10/30

Y1 - 2014/10/30

N2 - The present invention provides ICOSL specific antigen binding molecules which are isolated from immunized and synthetic Elasmobranchii derived libraries. In particular, the present invention relates to shark Variable New Antigen Receptor (VNAR) domains that specifically bind and neutralize the activity of human Induced Co-Stimulatory Ligand (ICOSL). The neutralizing VNAR domains are isolated from two independent sources; an immunized nurse shark library and a synthetic spiny dogfish framework fusion library. The molecules may be formulated as pharmaceutical compositions and used in medicine.

AB - The present invention provides ICOSL specific antigen binding molecules which are isolated from immunized and synthetic Elasmobranchii derived libraries. In particular, the present invention relates to shark Variable New Antigen Receptor (VNAR) domains that specifically bind and neutralize the activity of human Induced Co-Stimulatory Ligand (ICOSL). The neutralizing VNAR domains are isolated from two independent sources; an immunized nurse shark library and a synthetic spiny dogfish framework fusion library. The molecules may be formulated as pharmaceutical compositions and used in medicine.

UR - https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141030&DB=EPODOC&locale=en_EP&CC=WO&NR=2014173975A1&KC=A1&ND=5

M3 - Patent

ER -

ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL

Abstract

UN SDGs

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