Isolation, structure elucidation and biological activity of hederacine A and B, two unique alkaloids from Glechoma hederaceae

Y. Kumarasamy, P. J. Cox, Marcel Jaspars, L. Nahar, S. D. Sarker

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Preparative HPLC purification of a methanol extract of the aerial parts of Glechoma hederaceae has yielded two unique alkaloids, hederacine A (1) and hederacine B (2). The structures of these compounds were established unequivocally by UV, IR, MS and a series of 1D and 2D NMR analyses. These alkaloids were inactive against any of the 11 bacterial species at test concentrations, but showed prominent toxicity in the brine shrimp lethality assay (LC(50)s=3.2, 14.0 and 2.7 mug/mL, respectively, for 1, 2 and the positive control, podophyllotoxin). (C) 2003 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)6403-6407
Number of pages4
JournalTetrahedron
Volume59
Issue number59
DOIs
Publication statusPublished - 2003

Keywords

  • Glechoma hederaceae
  • Lamiaceae
  • alkaloids
  • pyrrolidine
  • tropane
  • brine shrimp lethality assay
  • MOLECULAR MECHANICS
  • BIOACTIVITY

Cite this

Isolation, structure elucidation and biological activity of hederacine A and B, two unique alkaloids from Glechoma hederaceae. / Kumarasamy, Y.; Cox, P. J.; Jaspars, Marcel; Nahar, L.; Sarker, S. D.

In: Tetrahedron, Vol. 59, No. 59, 2003, p. 6403-6407.

Research output: Contribution to journalArticle

Kumarasamy, Y. ; Cox, P. J. ; Jaspars, Marcel ; Nahar, L. ; Sarker, S. D. / Isolation, structure elucidation and biological activity of hederacine A and B, two unique alkaloids from Glechoma hederaceae. In: Tetrahedron. 2003 ; Vol. 59, No. 59. pp. 6403-6407.
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AU - Sarker, S. D.

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AB - Preparative HPLC purification of a methanol extract of the aerial parts of Glechoma hederaceae has yielded two unique alkaloids, hederacine A (1) and hederacine B (2). The structures of these compounds were established unequivocally by UV, IR, MS and a series of 1D and 2D NMR analyses. These alkaloids were inactive against any of the 11 bacterial species at test concentrations, but showed prominent toxicity in the brine shrimp lethality assay (LC(50)s=3.2, 14.0 and 2.7 mug/mL, respectively, for 1, 2 and the positive control, podophyllotoxin). (C) 2003 Elsevier Ltd. All rights reserved.

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