jSerum autoantibody responses to myelin oligodendrocyte glycoprotein and myelin basic protein in X-linked adrenoleukodystrophy and multiple sclerosis.

S. Schmidt, C. G. Haase, L. Bezman, H. Moser, M. Schmidt, W. Kohler, Christopher Linington, T. Klockgether

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    26 Citations (Scopus)

    Abstract

    We analyzed the sera of 51 patients with various phenotypes of X-linked adrenoleukodystrophy (X-ALD), 20 patients with multiple sclerosis (MS) and 22 healthy volunteers for the presence of autoantibodies specific for the recombinant extracellular immunoglobulin-like domain of human myelin oligodendrocyte glycoprotein (rhMOG(Igd)) and myelin basic protein (MBP). Anti-rhMOG(Igd) autoantibodies were significantly more frequent in X-ALD and MS patients as opposed to healthy individuals (p<0.05). Anti-MBP autoantibodies were present in about one-fourth of X-ALD and MS patients but in less than 10% of healthy individuals. Anti-rhMOG(Igd) autoantibody responses were not accompanied by increased T cell reactivity against rhMOG(Igd). These findings may have important implications for the understanding of humoral anti-myelin immunoreactivity in demyelinating diseases of the central nervous system such as X-ALD and MS. (C) 2001 Elsevier Science B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)88-94
    Number of pages6
    JournalJournal of Neuroimmunology
    Volume119
    DOIs
    Publication statusPublished - 2001

    Keywords

    • multiple sclerosis
    • X-linked adrenoleukodystrophy
    • myelin oligodendrocyte glycoprotein
    • myelin basic protein
    • PROTEOLIPID PROTEIN
    • B-CELL
    • DEMYELINATION
    • ANTIBODY
    • LESIONS
    • PATHOGENESIS
    • DISORDERS
    • PHENOTYPE

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