jSerum autoantibody responses to myelin oligodendrocyte glycoprotein and myelin basic protein in X-linked adrenoleukodystrophy and multiple sclerosis.

S. Schmidt, C. G. Haase, L. Bezman, H. Moser, M. Schmidt, W. Kohler, Christopher Linington, T. Klockgether

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    We analyzed the sera of 51 patients with various phenotypes of X-linked adrenoleukodystrophy (X-ALD), 20 patients with multiple sclerosis (MS) and 22 healthy volunteers for the presence of autoantibodies specific for the recombinant extracellular immunoglobulin-like domain of human myelin oligodendrocyte glycoprotein (rhMOG(Igd)) and myelin basic protein (MBP). Anti-rhMOG(Igd) autoantibodies were significantly more frequent in X-ALD and MS patients as opposed to healthy individuals (p<0.05). Anti-MBP autoantibodies were present in about one-fourth of X-ALD and MS patients but in less than 10% of healthy individuals. Anti-rhMOG(Igd) autoantibody responses were not accompanied by increased T cell reactivity against rhMOG(Igd). These findings may have important implications for the understanding of humoral anti-myelin immunoreactivity in demyelinating diseases of the central nervous system such as X-ALD and MS. (C) 2001 Elsevier Science B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)88-94
    Number of pages6
    JournalJournal of Neuroimmunology
    Volume119
    DOIs
    Publication statusPublished - 2001

    Keywords

    • multiple sclerosis
    • X-linked adrenoleukodystrophy
    • myelin oligodendrocyte glycoprotein
    • myelin basic protein
    • PROTEOLIPID PROTEIN
    • B-CELL
    • DEMYELINATION
    • ANTIBODY
    • LESIONS
    • PATHOGENESIS
    • DISORDERS
    • PHENOTYPE

    Cite this

    jSerum autoantibody responses to myelin oligodendrocyte glycoprotein and myelin basic protein in X-linked adrenoleukodystrophy and multiple sclerosis. / Schmidt, S.; Haase, C. G.; Bezman, L.; Moser, H.; Schmidt, M.; Kohler, W.; Linington, Christopher; Klockgether, T.

    In: Journal of Neuroimmunology, Vol. 119, 2001, p. 88-94.

    Research output: Contribution to journalArticle

    Schmidt, S. ; Haase, C. G. ; Bezman, L. ; Moser, H. ; Schmidt, M. ; Kohler, W. ; Linington, Christopher ; Klockgether, T. / jSerum autoantibody responses to myelin oligodendrocyte glycoprotein and myelin basic protein in X-linked adrenoleukodystrophy and multiple sclerosis. In: Journal of Neuroimmunology. 2001 ; Vol. 119. pp. 88-94.
    @article{13d23f17364a4f1289735c05494ec887,
    title = "jSerum autoantibody responses to myelin oligodendrocyte glycoprotein and myelin basic protein in X-linked adrenoleukodystrophy and multiple sclerosis.",
    abstract = "We analyzed the sera of 51 patients with various phenotypes of X-linked adrenoleukodystrophy (X-ALD), 20 patients with multiple sclerosis (MS) and 22 healthy volunteers for the presence of autoantibodies specific for the recombinant extracellular immunoglobulin-like domain of human myelin oligodendrocyte glycoprotein (rhMOG(Igd)) and myelin basic protein (MBP). Anti-rhMOG(Igd) autoantibodies were significantly more frequent in X-ALD and MS patients as opposed to healthy individuals (p<0.05). Anti-MBP autoantibodies were present in about one-fourth of X-ALD and MS patients but in less than 10{\%} of healthy individuals. Anti-rhMOG(Igd) autoantibody responses were not accompanied by increased T cell reactivity against rhMOG(Igd). These findings may have important implications for the understanding of humoral anti-myelin immunoreactivity in demyelinating diseases of the central nervous system such as X-ALD and MS. (C) 2001 Elsevier Science B.V. All rights reserved.",
    keywords = "multiple sclerosis, X-linked adrenoleukodystrophy, myelin oligodendrocyte glycoprotein, myelin basic protein, PROTEOLIPID PROTEIN, B-CELL, DEMYELINATION, ANTIBODY, LESIONS, PATHOGENESIS, DISORDERS, PHENOTYPE",
    author = "S. Schmidt and Haase, {C. G.} and L. Bezman and H. Moser and M. Schmidt and W. Kohler and Christopher Linington and T. Klockgether",
    year = "2001",
    doi = "10.1016/S0165-5728(01)00345-9",
    language = "English",
    volume = "119",
    pages = "88--94",
    journal = "Journal of Neuroimmunology",
    issn = "0165-5728",
    publisher = "Elsevier",

    }

    TY - JOUR

    T1 - jSerum autoantibody responses to myelin oligodendrocyte glycoprotein and myelin basic protein in X-linked adrenoleukodystrophy and multiple sclerosis.

    AU - Schmidt, S.

    AU - Haase, C. G.

    AU - Bezman, L.

    AU - Moser, H.

    AU - Schmidt, M.

    AU - Kohler, W.

    AU - Linington, Christopher

    AU - Klockgether, T.

    PY - 2001

    Y1 - 2001

    N2 - We analyzed the sera of 51 patients with various phenotypes of X-linked adrenoleukodystrophy (X-ALD), 20 patients with multiple sclerosis (MS) and 22 healthy volunteers for the presence of autoantibodies specific for the recombinant extracellular immunoglobulin-like domain of human myelin oligodendrocyte glycoprotein (rhMOG(Igd)) and myelin basic protein (MBP). Anti-rhMOG(Igd) autoantibodies were significantly more frequent in X-ALD and MS patients as opposed to healthy individuals (p<0.05). Anti-MBP autoantibodies were present in about one-fourth of X-ALD and MS patients but in less than 10% of healthy individuals. Anti-rhMOG(Igd) autoantibody responses were not accompanied by increased T cell reactivity against rhMOG(Igd). These findings may have important implications for the understanding of humoral anti-myelin immunoreactivity in demyelinating diseases of the central nervous system such as X-ALD and MS. (C) 2001 Elsevier Science B.V. All rights reserved.

    AB - We analyzed the sera of 51 patients with various phenotypes of X-linked adrenoleukodystrophy (X-ALD), 20 patients with multiple sclerosis (MS) and 22 healthy volunteers for the presence of autoantibodies specific for the recombinant extracellular immunoglobulin-like domain of human myelin oligodendrocyte glycoprotein (rhMOG(Igd)) and myelin basic protein (MBP). Anti-rhMOG(Igd) autoantibodies were significantly more frequent in X-ALD and MS patients as opposed to healthy individuals (p<0.05). Anti-MBP autoantibodies were present in about one-fourth of X-ALD and MS patients but in less than 10% of healthy individuals. Anti-rhMOG(Igd) autoantibody responses were not accompanied by increased T cell reactivity against rhMOG(Igd). These findings may have important implications for the understanding of humoral anti-myelin immunoreactivity in demyelinating diseases of the central nervous system such as X-ALD and MS. (C) 2001 Elsevier Science B.V. All rights reserved.

    KW - multiple sclerosis

    KW - X-linked adrenoleukodystrophy

    KW - myelin oligodendrocyte glycoprotein

    KW - myelin basic protein

    KW - PROTEOLIPID PROTEIN

    KW - B-CELL

    KW - DEMYELINATION

    KW - ANTIBODY

    KW - LESIONS

    KW - PATHOGENESIS

    KW - DISORDERS

    KW - PHENOTYPE

    U2 - 10.1016/S0165-5728(01)00345-9

    DO - 10.1016/S0165-5728(01)00345-9

    M3 - Article

    VL - 119

    SP - 88

    EP - 94

    JO - Journal of Neuroimmunology

    JF - Journal of Neuroimmunology

    SN - 0165-5728

    ER -