KIR expression shapes cytotoxic repertoires: a developmental program of survival

Neil Thomas Young, Markus Uhrberg

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

We hypothesize a sequential program of expression of the leukocyte-receptor complex (LRC) in CD8+T cells, associated with cellular activation and the subsequent establishment of immune homeostasis through resistance to apoptosis. This program, which is consistent with the linear development of memory CD8+ T cells, represents an ordered expression of genes during differentiation, analogous to expression of the homeobox- or globin-gene clusters. Our model not only has implications for the development and maintenance of T-cell memory but also, relates to the formation of LRC repertoires in other cell types, particularly, the development of killer-cell Ig-like receptor (KIR) repertoires in natural-killer-cell precursors.
Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalTrends in Immunology
Volume23
Issue number2
DOIs
Publication statusPublished - 1 Feb 2002

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Keywords

  • Animals
  • CD8-Positive T-Lymphocytes
  • Cell Survival
  • Cytotoxicity, Immunologic
  • Humans
  • Immunologic Memory
  • Killer Cells, Natural
  • Receptors, Immunologic
  • Receptors, KIR
  • T-Lymphocytes, Regulatory
  • Leukocyte receptor complex
  • Killer Ig-like receptor
  • activation-induced cell death
  • immunology
  • development
  • genetics

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