KIR expression shapes cytotoxic repertoires:  a developmental program of survival

Neil Thomas Young; Markus Uhrberg

doi:10.1016/S1471-4906(01)02113-5

KIR expression shapes cytotoxic repertoires: a developmental program of survival

Neil Thomas Young, Markus Uhrberg

Applied Medicine

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

We hypothesize a sequential program of expression of the leukocyte-receptor complex (LRC) in CD8+T cells, associated with cellular activation and the subsequent establishment of immune homeostasis through resistance to apoptosis. This program, which is consistent with the linear development of memory CD8+ T cells, represents an ordered expression of genes during differentiation, analogous to expression of the homeobox- or globin-gene clusters. Our model not only has implications for the development and maintenance of T-cell memory but also, relates to the formation of LRC repertoires in other cell types, particularly, the development of killer-cell Ig-like receptor (KIR) repertoires in natural-killer-cell precursors.

Original language	English
Pages (from-to)	71-75
Number of pages	5
Journal	Trends in Immunology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/S1471-4906(01)02113-5
Publication status	Published - 1 Feb 2002

Keywords

Animals
CD8-Positive T-Lymphocytes
Cell Survival
Cytotoxicity, Immunologic
Humans
Immunologic Memory
Killer Cells, Natural
Receptors, Immunologic
Receptors, KIR
T-Lymphocytes, Regulatory
Leukocyte receptor complex
Killer Ig-like receptor
activation-induced cell death
immunology
development
genetics

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10.1016/S1471-4906(01)02113-5

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title = "KIR expression shapes cytotoxic repertoires: a developmental program of survival",

abstract = "We hypothesize a sequential program of expression of the leukocyte-receptor complex (LRC) in CD8+T cells, associated with cellular activation and the subsequent establishment of immune homeostasis through resistance to apoptosis. This program, which is consistent with the linear development of memory CD8+ T cells, represents an ordered expression of genes during differentiation, analogous to expression of the homeobox- or globin-gene clusters. Our model not only has implications for the development and maintenance of T-cell memory but also, relates to the formation of LRC repertoires in other cell types, particularly, the development of killer-cell Ig-like receptor (KIR) repertoires in natural-killer-cell precursors.",

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T1 - KIR expression shapes cytotoxic repertoires

T2 - a developmental program of survival

AU - Young, Neil Thomas

AU - Uhrberg, Markus

PY - 2002/2/1

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N2 - We hypothesize a sequential program of expression of the leukocyte-receptor complex (LRC) in CD8+T cells, associated with cellular activation and the subsequent establishment of immune homeostasis through resistance to apoptosis. This program, which is consistent with the linear development of memory CD8+ T cells, represents an ordered expression of genes during differentiation, analogous to expression of the homeobox- or globin-gene clusters. Our model not only has implications for the development and maintenance of T-cell memory but also, relates to the formation of LRC repertoires in other cell types, particularly, the development of killer-cell Ig-like receptor (KIR) repertoires in natural-killer-cell precursors.

AB - We hypothesize a sequential program of expression of the leukocyte-receptor complex (LRC) in CD8+T cells, associated with cellular activation and the subsequent establishment of immune homeostasis through resistance to apoptosis. This program, which is consistent with the linear development of memory CD8+ T cells, represents an ordered expression of genes during differentiation, analogous to expression of the homeobox- or globin-gene clusters. Our model not only has implications for the development and maintenance of T-cell memory but also, relates to the formation of LRC repertoires in other cell types, particularly, the development of killer-cell Ig-like receptor (KIR) repertoires in natural-killer-cell precursors.

KW - Animals

KW - CD8-Positive T-Lymphocytes

KW - Cell Survival

KW - Cytotoxicity, Immunologic

KW - Humans

KW - Immunologic Memory

KW - Killer Cells, Natural

KW - Receptors, Immunologic

KW - Receptors, KIR

KW - T-Lymphocytes, Regulatory

KW - Leukocyte receptor complex

KW - Killer Ig-like receptor

KW - activation-induced cell death

KW - immunology

KW - development

KW - genetics

U2 - 10.1016/S1471-4906(01)02113-5

DO - 10.1016/S1471-4906(01)02113-5

M3 - Article

C2 - 11929129

SN - 1471-4906

VL - 23

SP - 71

EP - 75

JO - Trends in Immunology

JF - Trends in Immunology

IS - 2

ER -

KIR expression shapes cytotoxic repertoires: a developmental program of survival

Abstract

Keywords

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