Lack of association between apolipoprotein E genotype and ischaemic stroke in a Scottish population

Mary Joan MacLeod, R. P. De Lange, Gerome Daniel Breen, D. Meiklejohn, H. Lemmon, David Malcolm St Clair

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background Apolipoprotein E epsilon4 allele has been associated with increased risk of coronary heart disease, and is also a major genetic susceptibility locus for Alzheimer's disease. Some studies have shown an association between apoE genotype and ischaemic stroke or outcome following stroke, while other studies have failed to do so.
Materials and methods Using PCR and the Taqman fluorescence system to detect polymorphisms we examined apoE genotype in 266 ischaemic stroke cases and in a control population.
Results We found no association between apoeE epsilon 4 allele distribution and ischaemic stroke, or with outcome following stroke as measured using the Rankin score.
Conclusion This study disagrees with a recent meta-analysis, and suggests that further studies are required to clarify the exact relationship between apoE genotype and ischaemic stroke.

Original languageEnglish
Pages (from-to)570-573
Number of pages4
JournalEuropean Journal of Clinical Investigation
Volume31
Issue number7
DOIs
Publication statusPublished - Jul 2001

Keywords

  • apolipoprotein E genotype
  • apolipoprotein E epsilon 4 allele
  • ischaemic stroke
  • cerebrovascular disease
  • ischemic stroke
  • coronary disease
  • APOE genotype
  • E alleles
  • polymorphism
  • risk
  • meta-analysis
  • locus
  • gene

Cite this

Lack of association between apolipoprotein E genotype and ischaemic stroke in a Scottish population. / MacLeod, Mary Joan; De Lange, R. P.; Breen, Gerome Daniel; Meiklejohn, D.; Lemmon, H.; St Clair, David Malcolm.

In: European Journal of Clinical Investigation, Vol. 31, No. 7, 07.2001, p. 570-573.

Research output: Contribution to journalArticle

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abstract = "Background Apolipoprotein E epsilon4 allele has been associated with increased risk of coronary heart disease, and is also a major genetic susceptibility locus for Alzheimer's disease. Some studies have shown an association between apoE genotype and ischaemic stroke or outcome following stroke, while other studies have failed to do so. Materials and methods Using PCR and the Taqman fluorescence system to detect polymorphisms we examined apoE genotype in 266 ischaemic stroke cases and in a control population. Results We found no association between apoeE epsilon 4 allele distribution and ischaemic stroke, or with outcome following stroke as measured using the Rankin score. Conclusion This study disagrees with a recent meta-analysis, and suggests that further studies are required to clarify the exact relationship between apoE genotype and ischaemic stroke.",
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T1 - Lack of association between apolipoprotein E genotype and ischaemic stroke in a Scottish population

AU - MacLeod, Mary Joan

AU - De Lange, R. P.

AU - Breen, Gerome Daniel

AU - Meiklejohn, D.

AU - Lemmon, H.

AU - St Clair, David Malcolm

PY - 2001/7

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AB - Background Apolipoprotein E epsilon4 allele has been associated with increased risk of coronary heart disease, and is also a major genetic susceptibility locus for Alzheimer's disease. Some studies have shown an association between apoE genotype and ischaemic stroke or outcome following stroke, while other studies have failed to do so. Materials and methods Using PCR and the Taqman fluorescence system to detect polymorphisms we examined apoE genotype in 266 ischaemic stroke cases and in a control population. Results We found no association between apoeE epsilon 4 allele distribution and ischaemic stroke, or with outcome following stroke as measured using the Rankin score. Conclusion This study disagrees with a recent meta-analysis, and suggests that further studies are required to clarify the exact relationship between apoE genotype and ischaemic stroke.

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KW - coronary disease

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