Lack of association between schizophrenia and a polymorphism close to the cytosolic phospholipase A2 gene

S. A. Price, H. Fox, D. St Clair, D. J. Shaw*

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Biochemical studies have shown that a proportion of schizophrenics have an abnormal fatty acid composition in their red blood-cell membrane phospholipids and it has been suggested that this might be due to altered levels of the enzyme phospholipase A2 (PLA2). A recent report indicated that there was an association between schizophrenia and alleles of a poly-A repeat polymorphism close to the 5' end of the PLA2 gene. We report the analysis of this polymorphism in a series of 58 schizophrenic patients and 56 controls and find no evidence for allelic association.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalPsychiatric Genetics
Volume7
Issue number3
DOIs
Publication statusPublished - 1 Jan 1997

Keywords

  • Association
  • Genetics
  • Phospholipase
  • Phospholipids
  • PLA2
  • Schizophrenia

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