Lactate concentration in breast cancer using advanced magnetic resonance spectroscopy

Sai Man Cheung* (Corresponding Author), Ehab Husain, Yazan Masannat, Iain Miller, Klaus Wahle, Steven Heys, Jiabao He

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background
Precision medicine in breast cancer demands markers sensitive to early treatment response. Aerobic glycolysis (AG) upregulates lactate dehydrogenase A (LDH-A) with elevated lactate production; however, existing approaches for lactate quantification are either invasive or impractical clinically.

Methods
Thirty female patients (age 39–78 years, 15 grade II and 15 grade III) with invasive ductal carcinoma were enrolled. Lactate concentration was quantified from freshly excised whole tumours with double quantum filtered (DQF) magnetic resonance spectroscopy (MRS), and Nottingham Prognostic Index (NPI), LDH-A and proliferative marker Ki-67 were assessed histologically.

Results
There was a significantly higher lactate concentration (t = 2.2224, p = 0.0349) in grade III (7.7 ± 2.9 mM) than in grade II (5.5 ± 2.4 mM). Lactate concentration was correlated with NPI (ρ = 0.3618, p = 0.0495), but not with Ki-67 (ρ = 0.3041, p = 0.1023) or tumour size (r = 0.1716, p = 0.3645). Lactate concentration was negatively correlated with LDH-A (ρ = −0.3734, p = 0.0421).

Conclusion
Our results showed that lactate concentration in whole breast tumour from DQF MRS is sensitive to tumour grades and patient prognosis.
Original languageEnglish
JournalBritish Journal of Cancer
Early online date19 May 2020
DOIs
Publication statusE-pub ahead of print - 19 May 2020

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