Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix

Amy L Hall*, Hans Kromhout, Joachim Schüz, Susan Peters, Lützen Portengen, Roel Vermeulen, Antonio Agudo, Wolfgang Ahrens, Paolo Boffetta, Paul Brennan, Cristina Canova, David I Conway, Maria Paula Curado, Alexander W Daudt, Leticia Fernandez, Mia Hashibe, Claire M Healy, Ivana Holcatova, Kristina Kjaerheim, Rosalina KoifmanPagona Lagiou, Danièle Luce, Gary J Macfarlane, Ana Menezes, Gwenn Menvielle, Jerry Polesel, Heribert Ramroth, Lorenzo Richiardi, Isabelle Stücker, Peter Thomson, Marta Vilensky, Victor Wunsch-Filho, Amy Lee Yuan-Chin, Ariana Znaor, Kurt Straif, Ann Olsson

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders.

METHODS: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the INHANCE Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989-2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI & nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, chromium-VI & nickel) and females (asbestos, respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant.

RESULTS: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, p-values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI & nickel); strongest associations were for asbestos at >90%ile cumulative exposure (OR=1.3, CI=1.0-1.6), respirable crystalline silica at 30+ years duration (OR=1.4, CI=1.2-1.7) and 75%-90%ile cumulative exposure (OR=1.4, CI=1.1-1.8), chromium-VI at >75%ile cumulative exposure (OR=1.9, CI=1.2-3.0), and chromium-VI & nickel at 20-29 years duration (OR=1.5, CI=1.1-2.2).

CONCLUSIONS: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.

Original languageEnglish
Pages (from-to)145-154
Number of pages10
JournalEpidemiology
Volume31
Issue number1
Early online date1 Oct 2019
DOIs
Publication statusPublished - Jan 2020

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Laryngeal Neoplasms
Carcinogens
Asbestos
Silicon Dioxide
Odds Ratio
Lung
Nickel
Occupational Exposure
chromium hexavalent ion
Alcohol Drinking
Case-Control Studies
Smoking
Neoplasms

Keywords

  • Occupational Exposure
  • Laryngeal Neoplasms
  • Case–control Studies
  • Asbestos
  • Respirable Crystalline Silica
  • Nickel, Chromium(VI)
  • Carcinogens
  • Cancer
  • chromium(VI)
  • OCCUPATIONAL EXPOSURES
  • DUST EXPOSURE
  • SYN-JEM
  • Occupational exposure
  • Respirable crystalline silica
  • NECK-CANCER
  • TOBACCO
  • CIGARETTE-SMOKING
  • Laryngeal neoplasms
  • Case-control studies
  • POOLED ANALYSIS
  • ASBESTOS EXPOSURE
  • Nickel
  • INTERNATIONAL HEAD

ASJC Scopus subject areas

  • Epidemiology

Cite this

Hall, A. L., Kromhout, H., Schüz, J., Peters, S., Portengen, L., Vermeulen, R., ... Olsson, A. (2020). Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix. Epidemiology, 31(1), 145-154. https://doi.org/10.1097/EDE.0000000000001120

Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens : Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix. / Hall, Amy L; Kromhout, Hans; Schüz, Joachim; Peters, Susan; Portengen, Lützen; Vermeulen, Roel; Agudo, Antonio; Ahrens, Wolfgang; Boffetta, Paolo; Brennan, Paul; Canova, Cristina; Conway, David I; Curado, Maria Paula; Daudt, Alexander W; Fernandez, Leticia; Hashibe, Mia; Healy, Claire M; Holcatova, Ivana; Kjaerheim, Kristina; Koifman, Rosalina; Lagiou, Pagona; Luce, Danièle; Macfarlane, Gary J; Menezes, Ana; Menvielle, Gwenn; Polesel, Jerry; Ramroth, Heribert; Richiardi, Lorenzo; Stücker, Isabelle; Thomson, Peter; Vilensky, Marta; Wunsch-Filho, Victor; Yuan-Chin, Amy Lee; Znaor, Ariana; Straif, Kurt; Olsson, Ann.

In: Epidemiology, Vol. 31, No. 1, 01.2020, p. 145-154.

Research output: Contribution to journalArticle

Hall, AL, Kromhout, H, Schüz, J, Peters, S, Portengen, L, Vermeulen, R, Agudo, A, Ahrens, W, Boffetta, P, Brennan, P, Canova, C, Conway, DI, Curado, MP, Daudt, AW, Fernandez, L, Hashibe, M, Healy, CM, Holcatova, I, Kjaerheim, K, Koifman, R, Lagiou, P, Luce, D, Macfarlane, GJ, Menezes, A, Menvielle, G, Polesel, J, Ramroth, H, Richiardi, L, Stücker, I, Thomson, P, Vilensky, M, Wunsch-Filho, V, Yuan-Chin, AL, Znaor, A, Straif, K & Olsson, A 2020, 'Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix', Epidemiology, vol. 31, no. 1, pp. 145-154. https://doi.org/10.1097/EDE.0000000000001120
Hall, Amy L ; Kromhout, Hans ; Schüz, Joachim ; Peters, Susan ; Portengen, Lützen ; Vermeulen, Roel ; Agudo, Antonio ; Ahrens, Wolfgang ; Boffetta, Paolo ; Brennan, Paul ; Canova, Cristina ; Conway, David I ; Curado, Maria Paula ; Daudt, Alexander W ; Fernandez, Leticia ; Hashibe, Mia ; Healy, Claire M ; Holcatova, Ivana ; Kjaerheim, Kristina ; Koifman, Rosalina ; Lagiou, Pagona ; Luce, Danièle ; Macfarlane, Gary J ; Menezes, Ana ; Menvielle, Gwenn ; Polesel, Jerry ; Ramroth, Heribert ; Richiardi, Lorenzo ; Stücker, Isabelle ; Thomson, Peter ; Vilensky, Marta ; Wunsch-Filho, Victor ; Yuan-Chin, Amy Lee ; Znaor, Ariana ; Straif, Kurt ; Olsson, Ann. / Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens : Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix. In: Epidemiology. 2020 ; Vol. 31, No. 1. pp. 145-154.
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abstract = "INTRODUCTION: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders.METHODS: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the INHANCE Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989-2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI & nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, chromium-VI & nickel) and females (asbestos, respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant.RESULTS: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, p-values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI & nickel); strongest associations were for asbestos at >90{\%}ile cumulative exposure (OR=1.3, CI=1.0-1.6), respirable crystalline silica at 30+ years duration (OR=1.4, CI=1.2-1.7) and 75{\%}-90{\%}ile cumulative exposure (OR=1.4, CI=1.1-1.8), chromium-VI at >75{\%}ile cumulative exposure (OR=1.9, CI=1.2-3.0), and chromium-VI & nickel at 20-29 years duration (OR=1.5, CI=1.1-2.2).CONCLUSIONS: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.",
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author = "Hall, {Amy L} and Hans Kromhout and Joachim Sch{\"u}z and Susan Peters and L{\"u}tzen Portengen and Roel Vermeulen and Antonio Agudo and Wolfgang Ahrens and Paolo Boffetta and Paul Brennan and Cristina Canova and Conway, {David I} and Curado, {Maria Paula} and Daudt, {Alexander W} and Leticia Fernandez and Mia Hashibe and Healy, {Claire M} and Ivana Holcatova and Kristina Kjaerheim and Rosalina Koifman and Pagona Lagiou and Dani{\`e}le Luce and Macfarlane, {Gary J} and Ana Menezes and Gwenn Menvielle and Jerry Polesel and Heribert Ramroth and Lorenzo Richiardi and Isabelle St{\"u}cker and Peter Thomson and Marta Vilensky and Victor Wunsch-Filho and Yuan-Chin, {Amy Lee} and Ariana Znaor and Kurt Straif and Ann Olsson",
note = "Acknowledgments: We thank V{\'e}ronique Luzon (IARC) for her assistance with data management.",
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TY - JOUR

T1 - Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens

T2 - Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix

AU - Hall, Amy L

AU - Kromhout, Hans

AU - Schüz, Joachim

AU - Peters, Susan

AU - Portengen, Lützen

AU - Vermeulen, Roel

AU - Agudo, Antonio

AU - Ahrens, Wolfgang

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Canova, Cristina

AU - Conway, David I

AU - Curado, Maria Paula

AU - Daudt, Alexander W

AU - Fernandez, Leticia

AU - Hashibe, Mia

AU - Healy, Claire M

AU - Holcatova, Ivana

AU - Kjaerheim, Kristina

AU - Koifman, Rosalina

AU - Lagiou, Pagona

AU - Luce, Danièle

AU - Macfarlane, Gary J

AU - Menezes, Ana

AU - Menvielle, Gwenn

AU - Polesel, Jerry

AU - Ramroth, Heribert

AU - Richiardi, Lorenzo

AU - Stücker, Isabelle

AU - Thomson, Peter

AU - Vilensky, Marta

AU - Wunsch-Filho, Victor

AU - Yuan-Chin, Amy Lee

AU - Znaor, Ariana

AU - Straif, Kurt

AU - Olsson, Ann

N1 - Acknowledgments: We thank Véronique Luzon (IARC) for her assistance with data management.

PY - 2020/1

Y1 - 2020/1

N2 - INTRODUCTION: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders.METHODS: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the INHANCE Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989-2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI & nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, chromium-VI & nickel) and females (asbestos, respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant.RESULTS: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, p-values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI & nickel); strongest associations were for asbestos at >90%ile cumulative exposure (OR=1.3, CI=1.0-1.6), respirable crystalline silica at 30+ years duration (OR=1.4, CI=1.2-1.7) and 75%-90%ile cumulative exposure (OR=1.4, CI=1.1-1.8), chromium-VI at >75%ile cumulative exposure (OR=1.9, CI=1.2-3.0), and chromium-VI & nickel at 20-29 years duration (OR=1.5, CI=1.1-2.2).CONCLUSIONS: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.

AB - INTRODUCTION: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders.METHODS: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the INHANCE Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989-2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI & nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, chromium-VI & nickel) and females (asbestos, respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant.RESULTS: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, p-values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI & nickel); strongest associations were for asbestos at >90%ile cumulative exposure (OR=1.3, CI=1.0-1.6), respirable crystalline silica at 30+ years duration (OR=1.4, CI=1.2-1.7) and 75%-90%ile cumulative exposure (OR=1.4, CI=1.1-1.8), chromium-VI at >75%ile cumulative exposure (OR=1.9, CI=1.2-3.0), and chromium-VI & nickel at 20-29 years duration (OR=1.5, CI=1.1-2.2).CONCLUSIONS: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.

KW - Occupational Exposure

KW - Laryngeal Neoplasms

KW - Case–control Studies

KW - Asbestos

KW - Respirable Crystalline Silica

KW - Nickel, Chromium(VI)

KW - Carcinogens

KW - Cancer

KW - chromium(VI)

KW - OCCUPATIONAL EXPOSURES

KW - DUST EXPOSURE

KW - SYN-JEM

KW - Occupational exposure

KW - Respirable crystalline silica

KW - NECK-CANCER

KW - TOBACCO

KW - CIGARETTE-SMOKING

KW - Laryngeal neoplasms

KW - Case-control studies

KW - POOLED ANALYSIS

KW - ASBESTOS EXPOSURE

KW - Nickel

KW - INTERNATIONAL HEAD

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U2 - 10.1097/EDE.0000000000001120

DO - 10.1097/EDE.0000000000001120

M3 - Article

C2 - 31577634

VL - 31

SP - 145

EP - 154

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 1

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