Length and somatic mosaicism of CAG and GGN repeats in the androgen receptor gene and the risk of prostate cancer in men with benign prostatic hyperplasia

M. T. Tayeb, Caroline Clark, Graeme Ian Murray, Linda Sharp, Neva Elizabeth Haites, H. L. McLeod

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The most common malignancy in men worldwide is cancer of the prostate and determinants of prostate cancer (PRCa) risk remain largely unidentified. Many candidate genes may be involved in PRCa, such as those that are central to cellular growth and differentiation in the prostate gland. We analysed the polymorphic CAG and GGN repeats sequence in exon 1 of the AR gene to determine if the number of repeats might be an indicator of PRCa risk in patients with BPH.

Methods: The study evaluated 28 patients who presented with PRCa at least 6 years after the diagnosis of BPH and 56 matched patients with BPH who did not progress to PRCa over a comparable period.

Results: This study showed no evidence for association between the size of AR CAG and GGN repeats and the risk of the development of PRCa in patients with BPH. However, BPH patients with AR CAG instability had a 12-fold increased risk in development of PRCa.

Conclusions: While independent confirmation is required in further studies, these results provide a potential tool to assist prediction strategies for this important disease.

Original languageEnglish
Pages (from-to)21-26
Number of pages5
JournalAnnals of Saudi Medicine
Volume24
Issue number1
Publication statusPublished - 2004

Keywords

  • androgen receptor
  • prostate cancer
  • polymorphism
  • benign prostate hyperplasia
  • instability
  • triplet repeat instability
  • VITAMIN-D-RECEPTOR
  • NEOPLASTIC TRANSFORMATION
  • ENDOCRINE THERAPY
  • IN-VITRO
  • POLYMORPHISM
  • ASSOCIATION
  • INSTABILITY
  • EXPRESSION
  • STATISTICS
  • POPULATION

Cite this

Length and somatic mosaicism of CAG and GGN repeats in the androgen receptor gene and the risk of prostate cancer in men with benign prostatic hyperplasia. / Tayeb, M. T.; Clark, Caroline; Murray, Graeme Ian; Sharp, Linda; Haites, Neva Elizabeth; McLeod, H. L.

In: Annals of Saudi Medicine, Vol. 24, No. 1, 2004, p. 21-26.

Research output: Contribution to journalArticle

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abstract = "Background: The most common malignancy in men worldwide is cancer of the prostate and determinants of prostate cancer (PRCa) risk remain largely unidentified. Many candidate genes may be involved in PRCa, such as those that are central to cellular growth and differentiation in the prostate gland. We analysed the polymorphic CAG and GGN repeats sequence in exon 1 of the AR gene to determine if the number of repeats might be an indicator of PRCa risk in patients with BPH.Methods: The study evaluated 28 patients who presented with PRCa at least 6 years after the diagnosis of BPH and 56 matched patients with BPH who did not progress to PRCa over a comparable period.Results: This study showed no evidence for association between the size of AR CAG and GGN repeats and the risk of the development of PRCa in patients with BPH. However, BPH patients with AR CAG instability had a 12-fold increased risk in development of PRCa.Conclusions: While independent confirmation is required in further studies, these results provide a potential tool to assist prediction strategies for this important disease.",
keywords = "androgen receptor, prostate cancer, polymorphism, benign prostate hyperplasia, instability, triplet repeat instability, VITAMIN-D-RECEPTOR, NEOPLASTIC TRANSFORMATION, ENDOCRINE THERAPY, IN-VITRO, POLYMORPHISM, ASSOCIATION, INSTABILITY, EXPRESSION, STATISTICS, POPULATION",
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TY - JOUR

T1 - Length and somatic mosaicism of CAG and GGN repeats in the androgen receptor gene and the risk of prostate cancer in men with benign prostatic hyperplasia

AU - Tayeb, M. T.

AU - Clark, Caroline

AU - Murray, Graeme Ian

AU - Sharp, Linda

AU - Haites, Neva Elizabeth

AU - McLeod, H. L.

PY - 2004

Y1 - 2004

N2 - Background: The most common malignancy in men worldwide is cancer of the prostate and determinants of prostate cancer (PRCa) risk remain largely unidentified. Many candidate genes may be involved in PRCa, such as those that are central to cellular growth and differentiation in the prostate gland. We analysed the polymorphic CAG and GGN repeats sequence in exon 1 of the AR gene to determine if the number of repeats might be an indicator of PRCa risk in patients with BPH.Methods: The study evaluated 28 patients who presented with PRCa at least 6 years after the diagnosis of BPH and 56 matched patients with BPH who did not progress to PRCa over a comparable period.Results: This study showed no evidence for association between the size of AR CAG and GGN repeats and the risk of the development of PRCa in patients with BPH. However, BPH patients with AR CAG instability had a 12-fold increased risk in development of PRCa.Conclusions: While independent confirmation is required in further studies, these results provide a potential tool to assist prediction strategies for this important disease.

AB - Background: The most common malignancy in men worldwide is cancer of the prostate and determinants of prostate cancer (PRCa) risk remain largely unidentified. Many candidate genes may be involved in PRCa, such as those that are central to cellular growth and differentiation in the prostate gland. We analysed the polymorphic CAG and GGN repeats sequence in exon 1 of the AR gene to determine if the number of repeats might be an indicator of PRCa risk in patients with BPH.Methods: The study evaluated 28 patients who presented with PRCa at least 6 years after the diagnosis of BPH and 56 matched patients with BPH who did not progress to PRCa over a comparable period.Results: This study showed no evidence for association between the size of AR CAG and GGN repeats and the risk of the development of PRCa in patients with BPH. However, BPH patients with AR CAG instability had a 12-fold increased risk in development of PRCa.Conclusions: While independent confirmation is required in further studies, these results provide a potential tool to assist prediction strategies for this important disease.

KW - androgen receptor

KW - prostate cancer

KW - polymorphism

KW - benign prostate hyperplasia

KW - instability

KW - triplet repeat instability

KW - VITAMIN-D-RECEPTOR

KW - NEOPLASTIC TRANSFORMATION

KW - ENDOCRINE THERAPY

KW - IN-VITRO

KW - POLYMORPHISM

KW - ASSOCIATION

KW - INSTABILITY

KW - EXPRESSION

KW - STATISTICS

KW - POPULATION

M3 - Article

VL - 24

SP - 21

EP - 26

JO - Annals of Saudi Medicine

JF - Annals of Saudi Medicine

SN - 0256-4947

IS - 1

ER -