Leptin expression in placental and fetal tissues: does leptin have a functional role?

N Hoggard, Paul Haggarty, L Thomas, R.G. Lea

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Leptin is expressed in the placenta and in certain fetal tissues; however, little is known with regard to the function of this hormone in these tissues. To date, most evidence suggests that placental and/or fetal leptin acts as a fetal growth factor, but this is far from clear. Leptin may also have physiological effects on the placenta, including angiogenesis, growth and immunomodulation. The effects of placental leptin, if any, on the mother may contribute to endocrine-mediated alterations in energy balance, such as the mobilization of maternal fat, which occurs during the second half of pregnancy. In this review we will address these and other issues related to the expression of both placental and fetal leptin.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalBiochemical Society Transactions
Volume29
Publication statusPublished - May 2001

Keywords

  • leptin receptor
  • placenta
  • pregnancy
  • RECEPTOR MESSENGER-RNA
  • TUMOR-NECROSIS-FACTOR
  • NORMAL FEMALE MICE
  • SERUM LEPTIN
  • CORD-BLOOD
  • ADIPOSE-TISSUE
  • AMNIOTIC-FLUID
  • MATERNAL SERUM
  • PLASMA LEPTIN
  • PREGNANCY

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