Lessons, insights and newly developed tools emerging from behavioral phenotyping core facilities

Lior Bikovski*, Lianne Robinson, Asa Konradsson-Geuken, Klas Kullander, Thomas Viereckel, Svante Winberg, Erika Roman, Michael Tsoory

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Scientific investigations, in general, and research in neuroscience, in particular, are becoming ever more complex and require the integration of different techniques. Behavioral assays, which are among the most frequently used methodologies in neuroscience, nowadays rely on advanced, sophisticated technologies that require proficient application. Therefore, behavioral core facilities are becoming essential support units, as they provide the specialized expert research services needed to conduct advanced neuroscience. We here review the lessons learned and insights gathered from managing behavioral core facilities in different academic research institutes. This review addresses several issues, including: the advantages of behavioral core facilities, considerations for establishing a behavioral core facility, and the methodological advances made through calibration and standardization of assay protocols and the development of new assays. Collectively, the review highlights the benefits of both working within and collaborating with behavioral core facility units and emphasizes the potential progress in neuro-phenotyping that such facilities provide.

Original languageEnglish
Article number108597
Number of pages8
JournalJournal of Neuroscience Methods
Volume334
Early online date24 Jan 2020
DOIs
Publication statusPublished - 15 Mar 2020

Keywords

  • Behavioral core facilities
  • Calibration
  • Mice
  • New assays development
  • Zebra fish

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