TY - JOUR
T1 - Lessons, insights and newly developed tools emerging from behavioral phenotyping core facilities
AU - Bikovski, Lior
AU - Robinson, Lianne
AU - Konradsson-Geuken, Asa
AU - Kullander, Klas
AU - Viereckel, Thomas
AU - Winberg, Svante
AU - Roman, Erika
AU - Tsoory, Michael
N1 - Acknowledgements
The Uppsala University Behavioral Facility (UUBF) was established in 2011 and has since then received strategic funding from the Disciplinary Domain of Medicine and Pharmacy, Uppsala University, Sweden, that covers the operation of the infrastructure, infrastructure coordinator, subsidization of laboratory rent, behavioral tests and tracking software and equipment purchasing.
Dr. Michael Tsoory is the incumbent of the Carolito Stiftung Research Fellow Chair in Neurodegenerative Diseases at the Weizmann Institute of Science, Rehovot, Israel.
The Tel-Aviv University Myers Neuro-Behavioral Core Facility was established with a generous grant from the Myers Foundation, Cleveland, OH.
The Behavioural Neuroscience Core Facility within the University of Dundee was established through funding from the University of Dundee.
Publisher Copyright:
© 2020
PY - 2020/3/15
Y1 - 2020/3/15
N2 - Scientific investigations, in general, and research in neuroscience, in particular, are becoming ever more complex and require the integration of different techniques. Behavioral assays, which are among the most frequently used methodologies in neuroscience, nowadays rely on advanced, sophisticated technologies that require proficient application. Therefore, behavioral core facilities are becoming essential support units, as they provide the specialized expert research services needed to conduct advanced neuroscience. We here review the lessons learned and insights gathered from managing behavioral core facilities in different academic research institutes. This review addresses several issues, including: the advantages of behavioral core facilities, considerations for establishing a behavioral core facility, and the methodological advances made through calibration and standardization of assay protocols and the development of new assays. Collectively, the review highlights the benefits of both working within and collaborating with behavioral core facility units and emphasizes the potential progress in neuro-phenotyping that such facilities provide.
AB - Scientific investigations, in general, and research in neuroscience, in particular, are becoming ever more complex and require the integration of different techniques. Behavioral assays, which are among the most frequently used methodologies in neuroscience, nowadays rely on advanced, sophisticated technologies that require proficient application. Therefore, behavioral core facilities are becoming essential support units, as they provide the specialized expert research services needed to conduct advanced neuroscience. We here review the lessons learned and insights gathered from managing behavioral core facilities in different academic research institutes. This review addresses several issues, including: the advantages of behavioral core facilities, considerations for establishing a behavioral core facility, and the methodological advances made through calibration and standardization of assay protocols and the development of new assays. Collectively, the review highlights the benefits of both working within and collaborating with behavioral core facility units and emphasizes the potential progress in neuro-phenotyping that such facilities provide.
KW - Behavioral core facilities
KW - Calibration
KW - Mice
KW - New assays development
KW - Zebra fish
UR - http://www.scopus.com/inward/record.url?scp=85078450229&partnerID=8YFLogxK
U2 - 10.1016/j.jneumeth.2020.108597
DO - 10.1016/j.jneumeth.2020.108597
M3 - Review article
C2 - 31987912
AN - SCOPUS:85078450229
VL - 334
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
SN - 0165-0270
M1 - 108597
ER -