We would like to thank Tibben et al. for reporting their experience of identifying intermediate alleles (IA) reduced penetrance alleles (RPA) or, in one case, a fully penetrant allele (FPA) in the partners of individuals who had undertaken or requested pre-natal diagnosis for Huntington’s disease (HD) .
Quarrell, O. W., Delatycki, M. B., Clarke, A. J., Lahiri, N., Craufurd, D., Miedzybrodzka, Z., MacLeod, R., Renwick, P., & Tomlinson, C. (2019). Letter in Response to Tibben et al., Risk Assessment for Huntington's Disease for (Future) Offspring Requires Offering Preconceptional CAG Analysis to Both Partners. Journal of Huntington's disease, 8(3), 357-359. https://doi.org/10.3233/JHD-190360