TY - JOUR
T1 - Lifestyle and sociodemographic factors associated with high-risk HPV infection in UK women
AU - Cotton, Seonaidh Claire
AU - Sharp, Linda
AU - Seth, R.
AU - Masson, Lindsey Fiona
AU - Little, Julian
AU - Cruickshank, Margaret Eleanor
AU - Neal, K.
AU - Waugh, Norman Robert
AU - The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
PY - 2007
Y1 - 2007
N2 - The world age-standardised prevalence of high-risk HPV (hrHPV) infection among 5038 UK women aged 20–59 years, with a low-grade smear during 1999–2002, assessed for eligibility for TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) was 34.2%. High-risk HPV prevalence decreased with increasing age, from 61% at ages 20–24 years to 14–15% in those over 50 years. The age-standardised prevalence was 15.1, 30.7 and 52.7%, respectively, in women with a current normal, borderline nuclear abnormalities (BNA) and mild smear. In overall multivariate analyses, tertiary education, previous pregnancy and childbirth were associated with reduced hrHPV infection risk. Risk of infection was increased in non-white women, women not married/cohabiting, hormonal contraceptives users and current smokers. In stratified analyses, current smear status and age remained associated with hrHPV infection. Data of this type are relevant to the debate on human papillomavirus (HPV) testing in screening and development of HPV vaccination programmes.
AB - The world age-standardised prevalence of high-risk HPV (hrHPV) infection among 5038 UK women aged 20–59 years, with a low-grade smear during 1999–2002, assessed for eligibility for TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) was 34.2%. High-risk HPV prevalence decreased with increasing age, from 61% at ages 20–24 years to 14–15% in those over 50 years. The age-standardised prevalence was 15.1, 30.7 and 52.7%, respectively, in women with a current normal, borderline nuclear abnormalities (BNA) and mild smear. In overall multivariate analyses, tertiary education, previous pregnancy and childbirth were associated with reduced hrHPV infection risk. Risk of infection was increased in non-white women, women not married/cohabiting, hormonal contraceptives users and current smokers. In stratified analyses, current smear status and age remained associated with hrHPV infection. Data of this type are relevant to the debate on human papillomavirus (HPV) testing in screening and development of HPV vaccination programmes.
KW - HPV infection
KW - lifestyle factors
KW - cervical cancer
KW - human-papillomavirus infection
KW - cervical intraepithelial neoplasia
KW - young-women
KW - sexual-behavior
KW - contraceptive use
KW - prevalence surveys
KW - particle vaccine
KW - natural-history
KW - pooled analysis
KW - health-risk
U2 - 10.1038/sj.bjc.6603822
DO - 10.1038/sj.bjc.6603822
M3 - Article
VL - 97
SP - 133
EP - 139
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 1
ER -
