Lifestyle and sociodemographic factors associated with high-risk HPV infection in UK women

Seonaidh Claire Cotton (Corresponding Author), Linda Sharp, R. Seth, Lindsey Fiona Masson, Julian Little, Margaret Eleanor Cruickshank, K. Neal, Norman Robert Waugh, The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group

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Abstract

The world age-standardised prevalence of high-risk HPV (hrHPV) infection among 5038 UK women aged 20–59 years, with a low-grade smear during 1999–2002, assessed for eligibility for TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) was 34.2%. High-risk HPV prevalence decreased with increasing age, from 61% at ages 20–24 years to 14–15% in those over 50 years. The age-standardised prevalence was 15.1, 30.7 and 52.7%, respectively, in women with a current normal, borderline nuclear abnormalities (BNA) and mild smear. In overall multivariate analyses, tertiary education, previous pregnancy and childbirth were associated with reduced hrHPV infection risk. Risk of infection was increased in non-white women, women not married/cohabiting, hormonal contraceptives users and current smokers. In stratified analyses, current smear status and age remained associated with hrHPV infection. Data of this type are relevant to the debate on human papillomavirus (HPV) testing in screening and development of HPV vaccination programmes.
Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalBritish Journal of Cancer
Volume97
Issue number1
DOIs
Publication statusPublished - 2007

Keywords

  • HPV infection
  • lifestyle factors
  • cervical cancer
  • human-papillomavirus infection
  • cervical intraepithelial neoplasia
  • young-women
  • sexual-behavior
  • contraceptive use
  • prevalence surveys
  • particle vaccine
  • natural-history
  • pooled analysis
  • health-risk

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    Cotton, S. C., Sharp, L., Seth, R., Masson, L. F., Little, J., Cruickshank, M. E., Neal, K., Waugh, N. R., & The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group (2007). Lifestyle and sociodemographic factors associated with high-risk HPV infection in UK women. British Journal of Cancer, 97(1), 133-139. https://doi.org/10.1038/sj.bjc.6603822