Limited efficacy of universal leucodepletion in reducing the incidence of febrile nonhaemolytic reactions in red cell transfusions

J. Ibojie, M. A. Greiss, Stanislaw Urbaniak

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    This article demonstrates a 62% reduction in the number of febrile nonhaemolytic transfusion reactions (FNHTRs) and 50% reduction in febrile reaction rate associated with red cell transfusions following graded introduction of universal leucodepletion. Though this is a statistically significant reduction (P = 0.009), it shows limited efficacy in abrogating this complication. We also found a reduction in the proportion of cases of FNHTRs with lymphocytotoxic antibodies over the period studied from 54% in 1998, 28% in 1999 to 23% in 2000. This corresponds to a relative increase in the number of febrile reactions without human leucocyte antigen (HLA) antibodies following full implementation of universal leucodepletion, as the total number of reported reactions actually fell considerably during the period. The increase in the number of cases without HLA antibodies was directly proportional to the increase in the number of leucodepleted units used.

    Original languageEnglish
    Pages (from-to)181-185
    Number of pages4
    JournalTransfusion Medicine
    Volume12
    Issue number3
    DOIs
    Publication statusPublished - 2002

    Keywords

    • Creutzfeldt-Jakob disease
    • febrile nonhaemolytic transfusion reactions
    • lymphocytotoxic antibodies
    • universal leucodepletion
    • WBC REDUCTION
    • BLOOD COMPONENTS

    Cite this

    Limited efficacy of universal leucodepletion in reducing the incidence of febrile nonhaemolytic reactions in red cell transfusions. / Ibojie, J.; Greiss, M. A.; Urbaniak, Stanislaw.

    In: Transfusion Medicine, Vol. 12, No. 3, 2002, p. 181-185.

    Research output: Contribution to journalArticle

    @article{346ed8ac638a4491a28253c18f671ba3,
    title = "Limited efficacy of universal leucodepletion in reducing the incidence of febrile nonhaemolytic reactions in red cell transfusions",
    abstract = "This article demonstrates a 62{\%} reduction in the number of febrile nonhaemolytic transfusion reactions (FNHTRs) and 50{\%} reduction in febrile reaction rate associated with red cell transfusions following graded introduction of universal leucodepletion. Though this is a statistically significant reduction (P = 0.009), it shows limited efficacy in abrogating this complication. We also found a reduction in the proportion of cases of FNHTRs with lymphocytotoxic antibodies over the period studied from 54{\%} in 1998, 28{\%} in 1999 to 23{\%} in 2000. This corresponds to a relative increase in the number of febrile reactions without human leucocyte antigen (HLA) antibodies following full implementation of universal leucodepletion, as the total number of reported reactions actually fell considerably during the period. The increase in the number of cases without HLA antibodies was directly proportional to the increase in the number of leucodepleted units used.",
    keywords = "Creutzfeldt-Jakob disease, febrile nonhaemolytic transfusion reactions, lymphocytotoxic antibodies, universal leucodepletion, WBC REDUCTION, BLOOD COMPONENTS",
    author = "J. Ibojie and Greiss, {M. A.} and Stanislaw Urbaniak",
    year = "2002",
    doi = "10.1046/j.1365-3148.2002.00370.x",
    language = "English",
    volume = "12",
    pages = "181--185",
    journal = "Transfusion Medicine",
    issn = "0958-7578",
    publisher = "Wiley-Blackwell",
    number = "3",

    }

    TY - JOUR

    T1 - Limited efficacy of universal leucodepletion in reducing the incidence of febrile nonhaemolytic reactions in red cell transfusions

    AU - Ibojie, J.

    AU - Greiss, M. A.

    AU - Urbaniak, Stanislaw

    PY - 2002

    Y1 - 2002

    N2 - This article demonstrates a 62% reduction in the number of febrile nonhaemolytic transfusion reactions (FNHTRs) and 50% reduction in febrile reaction rate associated with red cell transfusions following graded introduction of universal leucodepletion. Though this is a statistically significant reduction (P = 0.009), it shows limited efficacy in abrogating this complication. We also found a reduction in the proportion of cases of FNHTRs with lymphocytotoxic antibodies over the period studied from 54% in 1998, 28% in 1999 to 23% in 2000. This corresponds to a relative increase in the number of febrile reactions without human leucocyte antigen (HLA) antibodies following full implementation of universal leucodepletion, as the total number of reported reactions actually fell considerably during the period. The increase in the number of cases without HLA antibodies was directly proportional to the increase in the number of leucodepleted units used.

    AB - This article demonstrates a 62% reduction in the number of febrile nonhaemolytic transfusion reactions (FNHTRs) and 50% reduction in febrile reaction rate associated with red cell transfusions following graded introduction of universal leucodepletion. Though this is a statistically significant reduction (P = 0.009), it shows limited efficacy in abrogating this complication. We also found a reduction in the proportion of cases of FNHTRs with lymphocytotoxic antibodies over the period studied from 54% in 1998, 28% in 1999 to 23% in 2000. This corresponds to a relative increase in the number of febrile reactions without human leucocyte antigen (HLA) antibodies following full implementation of universal leucodepletion, as the total number of reported reactions actually fell considerably during the period. The increase in the number of cases without HLA antibodies was directly proportional to the increase in the number of leucodepleted units used.

    KW - Creutzfeldt-Jakob disease

    KW - febrile nonhaemolytic transfusion reactions

    KW - lymphocytotoxic antibodies

    KW - universal leucodepletion

    KW - WBC REDUCTION

    KW - BLOOD COMPONENTS

    U2 - 10.1046/j.1365-3148.2002.00370.x

    DO - 10.1046/j.1365-3148.2002.00370.x

    M3 - Article

    VL - 12

    SP - 181

    EP - 185

    JO - Transfusion Medicine

    JF - Transfusion Medicine

    SN - 0958-7578

    IS - 3

    ER -