Abstract
Maximal animal performance may be limited by the ability of animals to dissipate heat; the heat dissipation limitation (HDL) theory. Since diets vary in the incidental heat produced during digestion (specific dynamic action, SDA), the HDL theory predicts lactating female mice consuming diets with lower SDA should have increased reproductive performance. Dietary fat has a lower SDA than dietary carbohydrate. Female mice were fed low (LF), medium (MF) or high fat (HF) diets (10%, 45% and 60% energy from fat respectively) from days 4-18 of lactation. HF and MF-fed mice weaned significantly heavier litters than LF mice. This was because they not only consumed more energy (metabolisable energy intake, E mei ; HF:306.5±25.0, MF:340.5±13.5 kJ d-1) at peak lactation, but also delivered more milk energy to their pups (milk energy output, E milk : 203.2±49.9, 229.3±42.2 kJ d-1 respectively) than the LF-fed mice (E mei =266.7±4.5, E milk =164.60±30.59 kJ d-1). This effect was greater than predicted from the SDA of the different diets combined with a mathematical model based on the HDL theory. Fatty acid profiles of the diets, milk and pups, showed significant correlations between the profiles. Besides reduced SDA, HF and MF-fed mice were probably able to directly transfer absorbed dietary fat into milk, reducing the heat production of lactogenesis, and enabling them to perform better than expected from the HDL model. In summary, HF and MF diets had beneficial effects on reproductive performance compared to the LF diet because they enabled mice to generate milk more efficiently with less incidental heat production.
| Original language | English |
|---|---|
| Article number | jeb180828 |
| Journal | Journal of Experimental Biology |
| Volume | 221 |
| Early online date | 23 Aug 2018 |
| DOIs | |
| Publication status | Published - 2018 |
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Keywords
- Journal Article
- Central and peripheral limits
- Heat dissipation limit
- Dietary fat
- Asymptotic food intake
- Digestibility
- Lactation performance
- Laboratory mouse
Cite this
Limits to sustained energy intake XXVIII : Beneficial effects of high dietary fat on lactation performance in mice. / Kagya-Agyemang, J K; Vaanholt, L M; Hambly, C; Król, E; Mitchell, S E; Speakman, J R (Corresponding Author).
In: Journal of Experimental Biology, Vol. 221, jeb180828, 2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Limits to sustained energy intake XXVIII
T2 - Beneficial effects of high dietary fat on lactation performance in mice
AU - Kagya-Agyemang, J K
AU - Vaanholt, L M
AU - Hambly, C
AU - Król, E
AU - Mitchell, S E
AU - Speakman, J R
N1 - JKA was supported by a scholarship from the government of the Republic of Ghana. LMV was supported by a Rubicon grant from the Netherlands Organisation for Scientific Research (NWO).
PY - 2018
Y1 - 2018
N2 - Maximal animal performance may be limited by the ability of animals to dissipate heat; the heat dissipation limitation (HDL) theory. Since diets vary in the incidental heat produced during digestion (specific dynamic action, SDA), the HDL theory predicts lactating female mice consuming diets with lower SDA should have increased reproductive performance. Dietary fat has a lower SDA than dietary carbohydrate. Female mice were fed low (LF), medium (MF) or high fat (HF) diets (10%, 45% and 60% energy from fat respectively) from days 4-18 of lactation. HF and MF-fed mice weaned significantly heavier litters than LF mice. This was because they not only consumed more energy (metabolisable energy intake, E mei ; HF:306.5±25.0, MF:340.5±13.5 kJ d-1) at peak lactation, but also delivered more milk energy to their pups (milk energy output, E milk : 203.2±49.9, 229.3±42.2 kJ d-1 respectively) than the LF-fed mice (E mei =266.7±4.5, E milk =164.60±30.59 kJ d-1). This effect was greater than predicted from the SDA of the different diets combined with a mathematical model based on the HDL theory. Fatty acid profiles of the diets, milk and pups, showed significant correlations between the profiles. Besides reduced SDA, HF and MF-fed mice were probably able to directly transfer absorbed dietary fat into milk, reducing the heat production of lactogenesis, and enabling them to perform better than expected from the HDL model. In summary, HF and MF diets had beneficial effects on reproductive performance compared to the LF diet because they enabled mice to generate milk more efficiently with less incidental heat production.
AB - Maximal animal performance may be limited by the ability of animals to dissipate heat; the heat dissipation limitation (HDL) theory. Since diets vary in the incidental heat produced during digestion (specific dynamic action, SDA), the HDL theory predicts lactating female mice consuming diets with lower SDA should have increased reproductive performance. Dietary fat has a lower SDA than dietary carbohydrate. Female mice were fed low (LF), medium (MF) or high fat (HF) diets (10%, 45% and 60% energy from fat respectively) from days 4-18 of lactation. HF and MF-fed mice weaned significantly heavier litters than LF mice. This was because they not only consumed more energy (metabolisable energy intake, E mei ; HF:306.5±25.0, MF:340.5±13.5 kJ d-1) at peak lactation, but also delivered more milk energy to their pups (milk energy output, E milk : 203.2±49.9, 229.3±42.2 kJ d-1 respectively) than the LF-fed mice (E mei =266.7±4.5, E milk =164.60±30.59 kJ d-1). This effect was greater than predicted from the SDA of the different diets combined with a mathematical model based on the HDL theory. Fatty acid profiles of the diets, milk and pups, showed significant correlations between the profiles. Besides reduced SDA, HF and MF-fed mice were probably able to directly transfer absorbed dietary fat into milk, reducing the heat production of lactogenesis, and enabling them to perform better than expected from the HDL model. In summary, HF and MF diets had beneficial effects on reproductive performance compared to the LF diet because they enabled mice to generate milk more efficiently with less incidental heat production.
KW - Journal Article
KW - Central and peripheral limits
KW - Heat dissipation limit
KW - Dietary fat
KW - Asymptotic food intake
KW - Digestibility
KW - Lactation performance
KW - Laboratory mouse
U2 - 10.1242/jeb.180828
DO - 10.1242/jeb.180828
M3 - Article
C2 - 29941615
VL - 221
JO - Journal of Experimental Biology
JF - Journal of Experimental Biology
SN - 0022-0949
M1 - jeb180828
ER -