Limits to sustained energy intake XXVIII: Beneficial effects of high dietary fat on lactation performance in mice

J K Kagya-Agyemang, L M Vaanholt, C Hambly, E Król, S E Mitchell, J R Speakman (Corresponding Author)

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Maximal animal performance may be limited by the ability of animals to dissipate heat; the heat dissipation limitation (HDL) theory. Since diets vary in the incidental heat produced during digestion (specific dynamic action, SDA), the HDL theory predicts lactating female mice consuming diets with lower SDA should have increased reproductive performance. Dietary fat has a lower SDA than dietary carbohydrate. Female mice were fed low (LF), medium (MF) or high fat (HF) diets (10%, 45% and 60% energy from fat respectively) from days 4-18 of lactation. HF and MF-fed mice weaned significantly heavier litters than LF mice. This was because they not only consumed more energy (metabolisable energy intake, E mei ; HF:306.5±25.0, MF:340.5±13.5 kJ d-1) at peak lactation, but also delivered more milk energy to their pups (milk energy output, E milk : 203.2±49.9, 229.3±42.2 kJ d-1 respectively) than the LF-fed mice (E mei =266.7±4.5, E milk =164.60±30.59 kJ d-1). This effect was greater than predicted from the SDA of the different diets combined with a mathematical model based on the HDL theory. Fatty acid profiles of the diets, milk and pups, showed significant correlations between the profiles. Besides reduced SDA, HF and MF-fed mice were probably able to directly transfer absorbed dietary fat into milk, reducing the heat production of lactogenesis, and enabling them to perform better than expected from the HDL model. In summary, HF and MF diets had beneficial effects on reproductive performance compared to the LF diet because they enabled mice to generate milk more efficiently with less incidental heat production.

Original languageEnglish
Article numberjeb180828
JournalJournal of Experimental Biology
Volume221
Early online date23 Aug 2018
DOIs
Publication statusPublished - 2018

Fingerprint

lactation
Dietary Fats
Energy Intake
Lactation
dietary fat
thermic effect of food
fat
energy intake
Milk
milk
Hot Temperature
diet
heat
mice
Diet
energy
Fats
dissipation
lipids
Thermogenesis

Keywords

  • Journal Article
  • Central and peripheral limits
  • Heat dissipation limit
  • Dietary fat
  • Asymptotic food intake
  • Digestibility
  • Lactation performance
  • Laboratory mouse

Cite this

@article{5d0f76429044489cbb32530f9ed6d9e0,
title = "Limits to sustained energy intake XXVIII: Beneficial effects of high dietary fat on lactation performance in mice",
abstract = "Maximal animal performance may be limited by the ability of animals to dissipate heat; the heat dissipation limitation (HDL) theory. Since diets vary in the incidental heat produced during digestion (specific dynamic action, SDA), the HDL theory predicts lactating female mice consuming diets with lower SDA should have increased reproductive performance. Dietary fat has a lower SDA than dietary carbohydrate. Female mice were fed low (LF), medium (MF) or high fat (HF) diets (10{\%}, 45{\%} and 60{\%} energy from fat respectively) from days 4-18 of lactation. HF and MF-fed mice weaned significantly heavier litters than LF mice. This was because they not only consumed more energy (metabolisable energy intake, E mei ; HF:306.5±25.0, MF:340.5±13.5 kJ d-1) at peak lactation, but also delivered more milk energy to their pups (milk energy output, E milk : 203.2±49.9, 229.3±42.2 kJ d-1 respectively) than the LF-fed mice (E mei =266.7±4.5, E milk =164.60±30.59 kJ d-1). This effect was greater than predicted from the SDA of the different diets combined with a mathematical model based on the HDL theory. Fatty acid profiles of the diets, milk and pups, showed significant correlations between the profiles. Besides reduced SDA, HF and MF-fed mice were probably able to directly transfer absorbed dietary fat into milk, reducing the heat production of lactogenesis, and enabling them to perform better than expected from the HDL model. In summary, HF and MF diets had beneficial effects on reproductive performance compared to the LF diet because they enabled mice to generate milk more efficiently with less incidental heat production.",
keywords = "Journal Article, Central and peripheral limits, Heat dissipation limit , Dietary fat , Asymptotic food intake , Digestibility, Lactation performance, Laboratory mouse",
author = "Kagya-Agyemang, {J K} and Vaanholt, {L M} and C Hambly and E Kr{\'o}l and Mitchell, {S E} and Speakman, {J R}",
note = "JKA was supported by a scholarship from the government of the Republic of Ghana. LMV was supported by a Rubicon grant from the Netherlands Organisation for Scientific Research (NWO).",
year = "2018",
doi = "10.1242/jeb.180828",
language = "English",
volume = "221",
journal = "Journal of Experimental Biology",
issn = "0022-0949",
publisher = "Company of Biologists Ltd",

}

TY - JOUR

T1 - Limits to sustained energy intake XXVIII

T2 - Beneficial effects of high dietary fat on lactation performance in mice

AU - Kagya-Agyemang, J K

AU - Vaanholt, L M

AU - Hambly, C

AU - Król, E

AU - Mitchell, S E

AU - Speakman, J R

N1 - JKA was supported by a scholarship from the government of the Republic of Ghana. LMV was supported by a Rubicon grant from the Netherlands Organisation for Scientific Research (NWO).

PY - 2018

Y1 - 2018

N2 - Maximal animal performance may be limited by the ability of animals to dissipate heat; the heat dissipation limitation (HDL) theory. Since diets vary in the incidental heat produced during digestion (specific dynamic action, SDA), the HDL theory predicts lactating female mice consuming diets with lower SDA should have increased reproductive performance. Dietary fat has a lower SDA than dietary carbohydrate. Female mice were fed low (LF), medium (MF) or high fat (HF) diets (10%, 45% and 60% energy from fat respectively) from days 4-18 of lactation. HF and MF-fed mice weaned significantly heavier litters than LF mice. This was because they not only consumed more energy (metabolisable energy intake, E mei ; HF:306.5±25.0, MF:340.5±13.5 kJ d-1) at peak lactation, but also delivered more milk energy to their pups (milk energy output, E milk : 203.2±49.9, 229.3±42.2 kJ d-1 respectively) than the LF-fed mice (E mei =266.7±4.5, E milk =164.60±30.59 kJ d-1). This effect was greater than predicted from the SDA of the different diets combined with a mathematical model based on the HDL theory. Fatty acid profiles of the diets, milk and pups, showed significant correlations between the profiles. Besides reduced SDA, HF and MF-fed mice were probably able to directly transfer absorbed dietary fat into milk, reducing the heat production of lactogenesis, and enabling them to perform better than expected from the HDL model. In summary, HF and MF diets had beneficial effects on reproductive performance compared to the LF diet because they enabled mice to generate milk more efficiently with less incidental heat production.

AB - Maximal animal performance may be limited by the ability of animals to dissipate heat; the heat dissipation limitation (HDL) theory. Since diets vary in the incidental heat produced during digestion (specific dynamic action, SDA), the HDL theory predicts lactating female mice consuming diets with lower SDA should have increased reproductive performance. Dietary fat has a lower SDA than dietary carbohydrate. Female mice were fed low (LF), medium (MF) or high fat (HF) diets (10%, 45% and 60% energy from fat respectively) from days 4-18 of lactation. HF and MF-fed mice weaned significantly heavier litters than LF mice. This was because they not only consumed more energy (metabolisable energy intake, E mei ; HF:306.5±25.0, MF:340.5±13.5 kJ d-1) at peak lactation, but also delivered more milk energy to their pups (milk energy output, E milk : 203.2±49.9, 229.3±42.2 kJ d-1 respectively) than the LF-fed mice (E mei =266.7±4.5, E milk =164.60±30.59 kJ d-1). This effect was greater than predicted from the SDA of the different diets combined with a mathematical model based on the HDL theory. Fatty acid profiles of the diets, milk and pups, showed significant correlations between the profiles. Besides reduced SDA, HF and MF-fed mice were probably able to directly transfer absorbed dietary fat into milk, reducing the heat production of lactogenesis, and enabling them to perform better than expected from the HDL model. In summary, HF and MF diets had beneficial effects on reproductive performance compared to the LF diet because they enabled mice to generate milk more efficiently with less incidental heat production.

KW - Journal Article

KW - Central and peripheral limits

KW - Heat dissipation limit

KW - Dietary fat

KW - Asymptotic food intake

KW - Digestibility

KW - Lactation performance

KW - Laboratory mouse

U2 - 10.1242/jeb.180828

DO - 10.1242/jeb.180828

M3 - Article

VL - 221

JO - Journal of Experimental Biology

JF - Journal of Experimental Biology

SN - 0022-0949

M1 - jeb180828

ER -