Limits to Sustained Energy Intake XXXI: Effect of Graded Levels of Dietary Fat on Lactation Performance in Swiss Mice

Yi Huang, Jazmin Osorio Mendoza, Catherine Hambly, Baoguo Li, Zengguang Jin, Li Li, Moshen Madizi, Sumei Hu, John R. Speakman* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The heat dissipation limit theory predicts that lactating female mice consuming diets with lower specific dynamic action (SDA) should have enhanced lactation performance. Dietary fat has lower SDA than other macronutrients. Here we tested the effects of graded dietary fat levels on lactating Swiss mice. We fed females five diets varying in fat content from 8.3 to 66.6%. Offspring of mothers fed diets of 41.7% fat and above were heavier and fatter at weaning compared with those of 8.3 and 25% fat diets. Mice on dietary fat contents of 41.7% and above had greater metabolizable energy intake at peak lactation (8.3%: 229.4±39.6; 25%: 278.8±25.8; 41.7%: 359.6±51.5; 58.3%: 353.7±43.6; 66.6%: 346±44.7 kJ day-1), lower daily energy expenditure (8.3%: 128.5±16; 25%: 131.6±8.4; 41.7%: 124.4±10.8; 58.3%: 115.1±10.5; 66.6%: 111.2±11.5 kJ day-1) and thus delivered more milk energy to their offspring (8.3%: 100.8±27.3; 25%: 147.2±25.1; 41.7%: 225.1±49.6; 58.3%: 238.6±40.1; 66.6%: 234.8±41.1 kJ day-1). Milk fat content (%) was unrelated to dietary fat content, indicating that females on higher fat diets (>41.7%) produced more rather than richer milk. Mothers consuming diets with 41.7% fat or above enhanced their lactation performance compared with those on 25% or less, probably by diverting dietary fat directly into the milk, thereby avoiding the costs of lipogenesis. At dietary fat contents above 41.7% they were either unable to transfer more dietary fat to the milk, or they chose not to do so, potentially because of a lack of benefit to the offspring that were increasingly fatter as maternal dietary fat increased.

Original languageEnglish
Article number221911
Number of pages13
JournalJournal of Experimental Biology
Volume223
Issue number10
Early online date14 Apr 2020
DOIs
Publication statusPublished - 22 May 2020

Keywords

  • Heat dissipation limitation
  • Graded dietary fat levels
  • Asymptotic food intake
  • Lactation performance
  • Laboratory mouse
  • Milk production
  • MILK-COMPOSITION
  • LABORATORY MICE
  • DOUBLY LABELED WATER
  • OUTPUT
  • FOOD-INTAKE
  • DEER MICE
  • FUR REMOVAL
  • COLD-EXPOSURE
  • METABOLIC-RATE
  • DISSIPATION LIMITATION HYPOTHESIS

ASJC Scopus subject areas

  • Insect Science
  • Ecology, Evolution, Behavior and Systematics
  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Physiology

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