Linkage-dependent gene flow in a house mouse chromosomal hybrid zone

T. Panithanarak, H. C. Hauffe, John F Dallas, A. Glover, R. G. Ward, J. B. Searle

    Research output: Contribution to journalArticle

    51 Citations (Scopus)

    Abstract

    In the alpine valley of Valtellina there are two Robertsonian chromosomal races of house mouse, the Poschiavo (POS: 2n = 24-26) characterized by metacentric 8.12 and acrocentrics 2 and 10 and the Upper Valtellina (UV: 2n = 22-24) characterized by metacentrics 2.8 and 10.12. The races inhabit separate villages in the valley except in Sommacologna and Sondalo, where they both occur together with hybrids. A total of 179 mice from 16 villages were typed at 13 microsatellite loci. Seven of these loci were localized close to the centromeres of chromosomes 10 and 12, with the prediction that these regions on the race-specific chromosomes would be the most likely to experience a barrier to gene flow. The remaining six loci were localized at the telomeres of chromosomes 10 and 12 and at the centromeres of chromosomes that do not differ between the races. Substantial differences in allelic frequencies were found between the villages with POS and UV races at five of the loci at the centromeres of chromosomes 10 and 12 but at none of the other loci. These differences were not found to distinguish the two races in Sommacologna and Sondalo. Therefore, the centromeric regions of race-specific chromosomes do appear to experience a barrier to gene flow, although this can break down under intense interbreeding between the races. These results are considered in the context of Harrison's (1990) concept of the semipermeability of hybrid zones to gene exchange and in relation to parapatric speciation.

    Original languageEnglish
    Pages (from-to)184-192
    Number of pages8
    JournalEvolution
    Volume58
    Issue number1
    DOIs
    Publication statusPublished - 2004

    Keywords

    • introgression
    • microsatellites
    • Mus musculus domesticus
    • Robertsonian fusions
    • speciation
    • MUS-MUSCULUS-DOMESTICUS
    • SOREX-ARANEUS
    • COMMON SHREW
    • MICE
    • POPULATION
    • SPECIATION
    • DIFFERENTIATION
    • EVOLUTION
    • HETEROZYGOSITY
    • POLYMORPHISM

    Cite this

    Panithanarak, T., Hauffe, H. C., Dallas, J. F., Glover, A., Ward, R. G., & Searle, J. B. (2004). Linkage-dependent gene flow in a house mouse chromosomal hybrid zone. Evolution, 58(1), 184-192. https://doi.org/10.1554/03-196

    Linkage-dependent gene flow in a house mouse chromosomal hybrid zone. / Panithanarak, T.; Hauffe, H. C.; Dallas, John F; Glover, A.; Ward, R. G.; Searle, J. B.

    In: Evolution, Vol. 58, No. 1, 2004, p. 184-192.

    Research output: Contribution to journalArticle

    Panithanarak, T, Hauffe, HC, Dallas, JF, Glover, A, Ward, RG & Searle, JB 2004, 'Linkage-dependent gene flow in a house mouse chromosomal hybrid zone', Evolution, vol. 58, no. 1, pp. 184-192. https://doi.org/10.1554/03-196
    Panithanarak T, Hauffe HC, Dallas JF, Glover A, Ward RG, Searle JB. Linkage-dependent gene flow in a house mouse chromosomal hybrid zone. Evolution. 2004;58(1):184-192. https://doi.org/10.1554/03-196
    Panithanarak, T. ; Hauffe, H. C. ; Dallas, John F ; Glover, A. ; Ward, R. G. ; Searle, J. B. / Linkage-dependent gene flow in a house mouse chromosomal hybrid zone. In: Evolution. 2004 ; Vol. 58, No. 1. pp. 184-192.
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    AU - Panithanarak, T.

    AU - Hauffe, H. C.

    AU - Dallas, John F

    AU - Glover, A.

    AU - Ward, R. G.

    AU - Searle, J. B.

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    AB - In the alpine valley of Valtellina there are two Robertsonian chromosomal races of house mouse, the Poschiavo (POS: 2n = 24-26) characterized by metacentric 8.12 and acrocentrics 2 and 10 and the Upper Valtellina (UV: 2n = 22-24) characterized by metacentrics 2.8 and 10.12. The races inhabit separate villages in the valley except in Sommacologna and Sondalo, where they both occur together with hybrids. A total of 179 mice from 16 villages were typed at 13 microsatellite loci. Seven of these loci were localized close to the centromeres of chromosomes 10 and 12, with the prediction that these regions on the race-specific chromosomes would be the most likely to experience a barrier to gene flow. The remaining six loci were localized at the telomeres of chromosomes 10 and 12 and at the centromeres of chromosomes that do not differ between the races. Substantial differences in allelic frequencies were found between the villages with POS and UV races at five of the loci at the centromeres of chromosomes 10 and 12 but at none of the other loci. These differences were not found to distinguish the two races in Sommacologna and Sondalo. Therefore, the centromeric regions of race-specific chromosomes do appear to experience a barrier to gene flow, although this can break down under intense interbreeding between the races. These results are considered in the context of Harrison's (1990) concept of the semipermeability of hybrid zones to gene exchange and in relation to parapatric speciation.

    KW - introgression

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    KW - Robertsonian fusions

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    KW - SOREX-ARANEUS

    KW - COMMON SHREW

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    KW - SPECIATION

    KW - DIFFERENTIATION

    KW - EVOLUTION

    KW - HETEROZYGOSITY

    KW - POLYMORPHISM

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    M3 - Article

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    SN - 0014-3820

    IS - 1

    ER -