Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver

Carlos M Minutti, Lucy H Jackson-Jones, Belen Garcia-Fojeda, Johanna A Knipper, Tara Sutherland, Nicola Logan, Emma Rinqvist, Raquel Guillamat-Prats, David A Ferenbach, Antonio Artigas, Cordula Stamme, Zissis C Chroneos, Dietmar M Zaiss, Cristina Casals, Judith Allen

Research output: Contribution to journalArticlepeer-review

125 Citations (Scopus)


The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type-2 mediated-macrophage activation. In the lung, surfactant protein A (SP-A) enhanced IL-4-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury following infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair following bacterial infection, but resulted in fibrosis following peritoneal dialysis. IL-4 drives production of these structurally related defense collagens, SP-A and C1q, and the expression of their receptor, myosin 18A. These findings reveal the existence within different tissues of an amplification system needed for local type 2 responses.
Original languageEnglish
Pages (from-to)1076-1080
Number of pages5
Issue number6342
Publication statusPublished - 11 May 2017


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