Long term effects of gestational diabetes on bone mineral density and fracture risk: Analysis of the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk) population-based study

Annes Ahmeidat, Sohinee Bhattacharya, Robert N Luben, Kay-Tee Khaw, Phyo Kyaw Myint* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Gestational diabetes mellitus (GDM) is a common pregnancy complication. This study aims to investigate the association between a history of GDM and bone mineral density (BMD), fractures, and falls in later life. Study design: We used data from the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk) where BMD at calcaneum was measured at second health check (1997–2000) using broadband ultrasound attenuation (BUA) and velocity of sound (VOS) in 7,515 women. Fractures and falls were documented from hospital admissions data via linkage with ENCORE (East Norfolk Commission Record) and history of GDM from health questionnaires at baseline. We examined the relationship between GDM and BUA/VOS using linear regression. Cox regression was used to estimate hazard ratios (HRs) for incident fractures and falls, controlling for age, BMI, smoking status, physical activity, area deprivation, self-reported stroke, use of diuretics, calcium and vitamin D supplements, social class and education, statin and total blood cholesterol, prevalent diabetes, hormone therapy and menopausal status. Results: History of GDM (n = 183) was not statistically significantly associated with BUA/VOS in fully adjusted linear regression models with unstandardised beta coefficients (standard error): -0.37 (1.40) and -5.41 (3.48). GDM was significantly (p < 0.05) associated with risk of hip and all fractures, fully adjusted HRs(95 %CI) 2.46(1.54−3.92) and 1.60(1.09−2.35), respectively. Median follow-up from first live birth to date of admission was 53 and 52 years, respectively. Conclusion: There was an association between history of GDM and risk of any fracture as well as hip fracture specifically. Further research is required to confirm this.

Original languageEnglish
Pages (from-to)68-73
Number of pages6
JournalMaturitas
Volume144
Early online date18 Nov 2020
DOIs
Publication statusPublished - 1 Feb 2021

Keywords

  • gestational diabetes
  • fracture risk
  • bone mineral density
  • pregnancy
  • Pregnancy
  • Bone mineral density
  • Gestational diabetes
  • Fracture risk
  • Bone Density
  • Humans
  • Middle Aged
  • Male
  • Calcaneus/diagnostic imaging
  • Fractures, Bone/epidemiology
  • Europe/epidemiology
  • Diabetes, Gestational/epidemiology
  • Ultrasonography
  • Adult
  • Female
  • Aged
  • Accidental Falls
  • Cohort Studies
  • QUANTITATIVE ULTRASOUND
  • INDEX

Fingerprint

Dive into the research topics of 'Long term effects of gestational diabetes on bone mineral density and fracture risk: Analysis of the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk) population-based study'. Together they form a unique fingerprint.

Cite this