Long term effects of gestational hypertension and pre-eclampsia on kidney function

Record linkage study

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6 Downloads (Pure)

Abstract

Objective: To assess the long term effects of hypertensive disorders of pregnancy on renal function.

Design: Cohort study where exposure was gestational hypertension or preeclampsia in the first pregnancy. Normotensive women formed the comparison group.

Setting: Aberdeen, Scotland.

Participants: All women with date of birth on or before 30th June 1969 and at least their first singleton delivery recorded in the Aberdeen Maternity and Neonatal Databank.

Methods: Participants were linked to the Renal Biochemistry Register, Scottish Morbidity Records, Scottish Renal Registry and National Register for deaths.

Main outcme measures: Occurrence of chronic kidney disease (CKD) as identified from renal function tests in later life, hospital admissions or death from kidney disease or recorded as receiving renal replacement therapy.

Results: CKD was diagnosed in 7.5% and 5.2% of women who previously had GH and PE respectively compared to 3.9% in normotensive women. The unadjusted odds ratio (95% confidence interval) of having CKD in PE was 2.04 (1.53, 2.71) and that for GH was 1.37 (1.15, 1.65), while the adjusted odds ratio (95% confidence interval) of CKD was 1.93 (1.44, 2.57) and 1.36 (1.13, 1.63) in women with PE and GH respectively. Kaplan–Meier curves of survival time to development of chronic kidney disease revealed that women with preeclampsia were susceptible to kidney function impairment earliest, followed by those with gestational hypertension.

Conclusions: There was an increased subsequent risk of CKD associated with hypertensive disorders of pregnancy. Women with GH and PE were also found to have CKD earlier than normotensive women.
Original languageEnglish
Pages (from-to)344-349
Number of pages6
JournalPregnancy Hypertension
Volume6
Issue number4
Early online date9 Aug 2016
DOIs
Publication statusPublished - Oct 2016

Fingerprint

Pregnancy Induced Hypertension
Pre-Eclampsia
Chronic Renal Insufficiency
Kidney
Pregnancy
Odds Ratio
Confidence Intervals
Renal Replacement Therapy
Kidney Diseases
Scotland
Biochemistry
Registries
Cohort Studies
Parturition
Databases
Morbidity
Survival

Keywords

  • gestational hypertension
  • preeclampsia
  • chronic kidney disease
  • record linkage

Cite this

@article{d1b9c7337afd4022a92f1ead20ea4faa,
title = "Long term effects of gestational hypertension and pre-eclampsia on kidney function: Record linkage study",
abstract = "Objective: To assess the long term effects of hypertensive disorders of pregnancy on renal function.Design: Cohort study where exposure was gestational hypertension or preeclampsia in the first pregnancy. Normotensive women formed the comparison group.Setting: Aberdeen, Scotland.Participants: All women with date of birth on or before 30th June 1969 and at least their first singleton delivery recorded in the Aberdeen Maternity and Neonatal Databank.Methods: Participants were linked to the Renal Biochemistry Register, Scottish Morbidity Records, Scottish Renal Registry and National Register for deaths.Main outcme measures: Occurrence of chronic kidney disease (CKD) as identified from renal function tests in later life, hospital admissions or death from kidney disease or recorded as receiving renal replacement therapy.Results: CKD was diagnosed in 7.5{\%} and 5.2{\%} of women who previously had GH and PE respectively compared to 3.9{\%} in normotensive women. The unadjusted odds ratio (95{\%} confidence interval) of having CKD in PE was 2.04 (1.53, 2.71) and that for GH was 1.37 (1.15, 1.65), while the adjusted odds ratio (95{\%} confidence interval) of CKD was 1.93 (1.44, 2.57) and 1.36 (1.13, 1.63) in women with PE and GH respectively. Kaplan–Meier curves of survival time to development of chronic kidney disease revealed that women with preeclampsia were susceptible to kidney function impairment earliest, followed by those with gestational hypertension.Conclusions: There was an increased subsequent risk of CKD associated with hypertensive disorders of pregnancy. Women with GH and PE were also found to have CKD earlier than normotensive women.",
keywords = "gestational hypertension, preeclampsia, chronic kidney disease, record linkage",
author = "D. Ayansina and C. Black and Hall, {S. J.} and Angharad Marks and C. Millar and Prescott, {G. J.} and K. Wilde and S. Bhattacharya",
note = "This research was funded by the Chief Scientists Office, Scotland (CZH/4/659).",
year = "2016",
month = "10",
doi = "10.1016/j.preghy.2016.08.231",
language = "English",
volume = "6",
pages = "344--349",
journal = "Pregnancy Hypertension",
issn = "2210-7789",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - Long term effects of gestational hypertension and pre-eclampsia on kidney function

T2 - Record linkage study

AU - Ayansina, D.

AU - Black, C.

AU - Hall, S. J.

AU - Marks, Angharad

AU - Millar, C.

AU - Prescott, G. J.

AU - Wilde, K.

AU - Bhattacharya, S.

N1 - This research was funded by the Chief Scientists Office, Scotland (CZH/4/659).

PY - 2016/10

Y1 - 2016/10

N2 - Objective: To assess the long term effects of hypertensive disorders of pregnancy on renal function.Design: Cohort study where exposure was gestational hypertension or preeclampsia in the first pregnancy. Normotensive women formed the comparison group.Setting: Aberdeen, Scotland.Participants: All women with date of birth on or before 30th June 1969 and at least their first singleton delivery recorded in the Aberdeen Maternity and Neonatal Databank.Methods: Participants were linked to the Renal Biochemistry Register, Scottish Morbidity Records, Scottish Renal Registry and National Register for deaths.Main outcme measures: Occurrence of chronic kidney disease (CKD) as identified from renal function tests in later life, hospital admissions or death from kidney disease or recorded as receiving renal replacement therapy.Results: CKD was diagnosed in 7.5% and 5.2% of women who previously had GH and PE respectively compared to 3.9% in normotensive women. The unadjusted odds ratio (95% confidence interval) of having CKD in PE was 2.04 (1.53, 2.71) and that for GH was 1.37 (1.15, 1.65), while the adjusted odds ratio (95% confidence interval) of CKD was 1.93 (1.44, 2.57) and 1.36 (1.13, 1.63) in women with PE and GH respectively. Kaplan–Meier curves of survival time to development of chronic kidney disease revealed that women with preeclampsia were susceptible to kidney function impairment earliest, followed by those with gestational hypertension.Conclusions: There was an increased subsequent risk of CKD associated with hypertensive disorders of pregnancy. Women with GH and PE were also found to have CKD earlier than normotensive women.

AB - Objective: To assess the long term effects of hypertensive disorders of pregnancy on renal function.Design: Cohort study where exposure was gestational hypertension or preeclampsia in the first pregnancy. Normotensive women formed the comparison group.Setting: Aberdeen, Scotland.Participants: All women with date of birth on or before 30th June 1969 and at least their first singleton delivery recorded in the Aberdeen Maternity and Neonatal Databank.Methods: Participants were linked to the Renal Biochemistry Register, Scottish Morbidity Records, Scottish Renal Registry and National Register for deaths.Main outcme measures: Occurrence of chronic kidney disease (CKD) as identified from renal function tests in later life, hospital admissions or death from kidney disease or recorded as receiving renal replacement therapy.Results: CKD was diagnosed in 7.5% and 5.2% of women who previously had GH and PE respectively compared to 3.9% in normotensive women. The unadjusted odds ratio (95% confidence interval) of having CKD in PE was 2.04 (1.53, 2.71) and that for GH was 1.37 (1.15, 1.65), while the adjusted odds ratio (95% confidence interval) of CKD was 1.93 (1.44, 2.57) and 1.36 (1.13, 1.63) in women with PE and GH respectively. Kaplan–Meier curves of survival time to development of chronic kidney disease revealed that women with preeclampsia were susceptible to kidney function impairment earliest, followed by those with gestational hypertension.Conclusions: There was an increased subsequent risk of CKD associated with hypertensive disorders of pregnancy. Women with GH and PE were also found to have CKD earlier than normotensive women.

KW - gestational hypertension

KW - preeclampsia

KW - chronic kidney disease

KW - record linkage

U2 - 10.1016/j.preghy.2016.08.231

DO - 10.1016/j.preghy.2016.08.231

M3 - Article

VL - 6

SP - 344

EP - 349

JO - Pregnancy Hypertension

JF - Pregnancy Hypertension

SN - 2210-7789

IS - 4

ER -