Abstract
AIMS
To assess the long-term patient reported outcomes following transobturator tension-free vaginal tapes (TO-TVT) in women with urodynamic mixed urinary incontinence (MUI).
METHODS
A secondary analysis of the 9-year follow-up of the E-TOT study: 341 women with predominant stress urinary incontinence symptoms were randomized to undergo either inside-out or outside-in TO-TVT between April 2005 and April 2007. Forty-eight women had preoperative urodynamic MUI and were available for 9-year follow-up. Primary outcome was the patient-reported success rate defined as very/much improved on Patient's Global Impression of Improvement PGI-I. Secondary outcomes included impact on women's quality of life, sexual function, overactive bladder symptoms,and late adverse events. Statistical analysis was performed using SPSS v.23.
RESULTS
Forty-eight women completed the 9-year follow-up, with adjusted response rate of 63%. The success based on the PGI-I was 64.6% (n = 31), with a further 14.6% (n = 7) who reported “improved.” There was no significant difference between groups (OR 1.11; 95%CI 0.33, 3.70; P > 0.999). Clinically significant improvement in quality of life was found in 85.3%. Cure of urgency and UUI was reported by 35% and 41%, whereas worsening was reported in 6.5% and 2.3%, respectively. One patient reported chronic groin/leg pain. The small sample size and the sizeable loss to follow-up are limitations in this study.
CONCLUSIONS
This is the first study to report the long-term outcomes of TO-TVT in women with urodynamic MUI; TO-TVT is associated with a good and sustained patient-reported success rate in women with MUI up to 9-years follow-up.
| Original language | English |
|---|---|
| Pages (from-to) | 902-908 |
| Number of pages | 7 |
| Journal | Neurourology and Urodynamics |
| Volume | 36 |
| Issue number | 4 |
| Early online date | 28 Dec 2016 |
| DOIs | |
| Publication status | Published - Apr 2017 |
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Keywords
- mid-urethral slings
- stress urinary incontinence
- tension-free vaginal tape
- transobturator tapes
- urinary incontinence
Cite this
Long-term outcomes for transobturator tension-free vaginal tapes in women with urodynamic mixed urinary incontinence. / Abdel-Fattah, Mohamed; Cao, Gabriel; Mostafa, Alyaa.
In: Neurourology and Urodynamics, Vol. 36, No. 4, 04.2017, p. 902-908.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term outcomes for transobturator tension-free vaginal tapes in women with urodynamic mixed urinary incontinence
AU - Abdel-Fattah, Mohamed
AU - Cao, Gabriel
AU - Mostafa, Alyaa
N1 - We thank Dr D. Kramakar (DK) (Research Fellow—University of Aberdeen) for sending out the questionnaires and collating the responses. We thank Lindsey Grant (LG) for performing the independent data entry cross-check. A special gratitude is to all the women whose excellent cooperation made this study successful. The initial phase of this study (up to 3-year follow-up) was funded by the Henry Smith Charity. Dr Karmakar was funded by IUGA Clinical Fellowship Grant 2014.
PY - 2017/4
Y1 - 2017/4
N2 - AIMSTo assess the long-term patient reported outcomes following transobturator tension-free vaginal tapes (TO-TVT) in women with urodynamic mixed urinary incontinence (MUI).METHODSA secondary analysis of the 9-year follow-up of the E-TOT study: 341 women with predominant stress urinary incontinence symptoms were randomized to undergo either inside-out or outside-in TO-TVT between April 2005 and April 2007. Forty-eight women had preoperative urodynamic MUI and were available for 9-year follow-up. Primary outcome was the patient-reported success rate defined as very/much improved on Patient's Global Impression of Improvement PGI-I. Secondary outcomes included impact on women's quality of life, sexual function, overactive bladder symptoms,and late adverse events. Statistical analysis was performed using SPSS v.23.RESULTSForty-eight women completed the 9-year follow-up, with adjusted response rate of 63%. The success based on the PGI-I was 64.6% (n = 31), with a further 14.6% (n = 7) who reported “improved.” There was no significant difference between groups (OR 1.11; 95%CI 0.33, 3.70; P > 0.999). Clinically significant improvement in quality of life was found in 85.3%. Cure of urgency and UUI was reported by 35% and 41%, whereas worsening was reported in 6.5% and 2.3%, respectively. One patient reported chronic groin/leg pain. The small sample size and the sizeable loss to follow-up are limitations in this study.CONCLUSIONSThis is the first study to report the long-term outcomes of TO-TVT in women with urodynamic MUI; TO-TVT is associated with a good and sustained patient-reported success rate in women with MUI up to 9-years follow-up.
AB - AIMSTo assess the long-term patient reported outcomes following transobturator tension-free vaginal tapes (TO-TVT) in women with urodynamic mixed urinary incontinence (MUI).METHODSA secondary analysis of the 9-year follow-up of the E-TOT study: 341 women with predominant stress urinary incontinence symptoms were randomized to undergo either inside-out or outside-in TO-TVT between April 2005 and April 2007. Forty-eight women had preoperative urodynamic MUI and were available for 9-year follow-up. Primary outcome was the patient-reported success rate defined as very/much improved on Patient's Global Impression of Improvement PGI-I. Secondary outcomes included impact on women's quality of life, sexual function, overactive bladder symptoms,and late adverse events. Statistical analysis was performed using SPSS v.23.RESULTSForty-eight women completed the 9-year follow-up, with adjusted response rate of 63%. The success based on the PGI-I was 64.6% (n = 31), with a further 14.6% (n = 7) who reported “improved.” There was no significant difference between groups (OR 1.11; 95%CI 0.33, 3.70; P > 0.999). Clinically significant improvement in quality of life was found in 85.3%. Cure of urgency and UUI was reported by 35% and 41%, whereas worsening was reported in 6.5% and 2.3%, respectively. One patient reported chronic groin/leg pain. The small sample size and the sizeable loss to follow-up are limitations in this study.CONCLUSIONSThis is the first study to report the long-term outcomes of TO-TVT in women with urodynamic MUI; TO-TVT is associated with a good and sustained patient-reported success rate in women with MUI up to 9-years follow-up.
KW - mid-urethral slings
KW - stress urinary incontinence
KW - tension-free vaginal tape
KW - transobturator tapes
KW - urinary incontinence
U2 - 10.1002/nau.23192
DO - 10.1002/nau.23192
M3 - Article
VL - 36
SP - 902
EP - 908
JO - Neurourology and Urodynamics
JF - Neurourology and Urodynamics
SN - 0733-2467
IS - 4
ER -