Long-term study of chronic oral aluminum exposure and spatial working memory in rats

R. E. von Linstow, Bettina Platt, Gernot Riedel

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The authors report an effort to advance animal models that mimic the cognitive decline of Alzheimer's disease. Rats were trained and repeatedly tested in a spatial delayed matching-to-position paradigm in the water maze, with the location of the submerged platform changing between, but not within, days. After Trial 1 (random search) and intertrial intervals of 30 s or 1 hr, memory was tested in Trial 2. Young rats quickly acquired this task and were repeatedly tested after different intervals over 7 months, with a slight increase in performance toward the end of testing, but no difference in latencies between delays. Oral long-term treatment of 1 group with 0.1 % aluminum caused no delay-dependent working memory deficit. This testing protocol may enable between- and within-subject long-term assessment of spatial working memory before and after drug treatment and may prove useful in animal models of progressive cognitive decline.

Original languageEnglish
Pages (from-to)351-356
Number of pages5
JournalBehavioral Neuroscience
Volume116
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • INDUCED NEUROFIBRILLARY DEGENERATION
  • EPISODIC-LIKE MEMORY
  • ALZHEIMERS-DISEASE
  • SYNAPTIC PLASTICITY
  • SYSTEMIC ALUMINUM
  • TOXICITY
  • BRAIN
  • HIPPOCAMPAL
  • RABBITS
  • POTENTIATION

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