Longitudinal diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease

Michael J. Firbank; Rosie Watson; Elijah Mak; Benjamin Aribisala; Robert Barber; Sean J. Colloby; Jiabao He; Andrew M. Blamire; John T. O'Brien

doi:10.1016/j.parkreldis.2016.01.003

Longitudinal diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease

Michael J. Firbank, Rosie Watson, Elijah Mak, Benjamin Aribisala, Robert Barber, Sean J. Colloby, Jiabao He, Andrew M. Blamire, John T. O'Brien

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Abstract

OBJECTIVE: Changes in the white matter of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) have been reported using diffusion weighted MRI, though few longitudinal studies have been done.

METHODS: We performed diffusion weighted MRI twice, a year apart on 23 AD, 14 DLB, and 32 healthy control subjects. Mean diffusivity (MD) and fractional anisotropy (FA) were calculated.

RESULTS: In AD, there were widespread regions where the longitudinal MD increase was greater than in controls, and small areas in the parietal and temporal lobes where it was greater in AD than DLB. In AD, decrease in brain volume correlated with increased MD. There were no significant differences in progression between DLB and controls.

CONCLUSIONS: In AD the white matter continues to degenerate during the disease process, whereas in DLB, changes in the white matter structure are a relatively early feature. Different mechanisms are likely to underpin changes in diffusivity.

Original language	English
Pages (from-to)	76-80
Number of pages	5
Journal	Parkinsonism & Related Disorders
Volume	24
Early online date	6 Jan 2016
DOIs	https://doi.org/10.1016/j.parkreldis.2016.01.003
Publication status	Published - Mar 2016

Keywords

Dementia with Lewy bodies
Alzheimer's disease
DWI
MRI

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© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 49.6 KBLicence: CC BY-NC-ND
Supplementary Material
©2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 978 KBLicence: CC BY-NC-ND
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© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 335 KBLicence: CC BY-NC-ND

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Firbank, M. J., Watson, R., Mak, E., Aribisala, B., Barber, R., Colloby, S. J., He, J., Blamire, A. M., & O'Brien, J. T. (2016). Longitudinal diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease. Parkinsonism & Related Disorders, 24, 76-80. https://doi.org/10.1016/j.parkreldis.2016.01.003

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title = "Longitudinal diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease",

abstract = "OBJECTIVE: Changes in the white matter of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) have been reported using diffusion weighted MRI, though few longitudinal studies have been done.METHODS: We performed diffusion weighted MRI twice, a year apart on 23 AD, 14 DLB, and 32 healthy control subjects. Mean diffusivity (MD) and fractional anisotropy (FA) were calculated.RESULTS: In AD, there were widespread regions where the longitudinal MD increase was greater than in controls, and small areas in the parietal and temporal lobes where it was greater in AD than DLB. In AD, decrease in brain volume correlated with increased MD. There were no significant differences in progression between DLB and controls.CONCLUSIONS: In AD the white matter continues to degenerate during the disease process, whereas in DLB, changes in the white matter structure are a relatively early feature. Different mechanisms are likely to underpin changes in diffusivity.",

keywords = "Dementia with Lewy bodies, Alzheimer's disease, DWI, MRI",

author = "Firbank, {Michael J.} and Rosie Watson and Elijah Mak and Benjamin Aribisala and Robert Barber and Colloby, {Sean J.} and Jiabao He and Blamire, {Andrew M.} and O'Brien, {John T.}",

note = "Acknowledgements The study was supported by the NIHR Biomedical Research Unit in Dementia and the Biomedical Research Centre awarded to Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, and the NIHR Biomedical Research Unit in Dementia and the Biomedical Research Centre awarded to Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. Elijah Mak was in receipt of a Gates Cambridge PhD studentship.",

year = "2016",

month = mar,

doi = "10.1016/j.parkreldis.2016.01.003",

language = "English",

volume = "24",

pages = "76--80",

journal = "Parkinsonism & Related Disorders",

issn = "1353-8020",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Longitudinal diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease

AU - Firbank, Michael J.

AU - Watson, Rosie

AU - Mak, Elijah

AU - Aribisala, Benjamin

AU - Barber, Robert

AU - Colloby, Sean J.

AU - He, Jiabao

AU - Blamire, Andrew M.

AU - O'Brien, John T.

N1 - Acknowledgements The study was supported by the NIHR Biomedical Research Unit in Dementia and the Biomedical Research Centre awarded to Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, and the NIHR Biomedical Research Unit in Dementia and the Biomedical Research Centre awarded to Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. Elijah Mak was in receipt of a Gates Cambridge PhD studentship.

PY - 2016/3

Y1 - 2016/3

N2 - OBJECTIVE: Changes in the white matter of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) have been reported using diffusion weighted MRI, though few longitudinal studies have been done.METHODS: We performed diffusion weighted MRI twice, a year apart on 23 AD, 14 DLB, and 32 healthy control subjects. Mean diffusivity (MD) and fractional anisotropy (FA) were calculated.RESULTS: In AD, there were widespread regions where the longitudinal MD increase was greater than in controls, and small areas in the parietal and temporal lobes where it was greater in AD than DLB. In AD, decrease in brain volume correlated with increased MD. There were no significant differences in progression between DLB and controls.CONCLUSIONS: In AD the white matter continues to degenerate during the disease process, whereas in DLB, changes in the white matter structure are a relatively early feature. Different mechanisms are likely to underpin changes in diffusivity.

AB - OBJECTIVE: Changes in the white matter of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) have been reported using diffusion weighted MRI, though few longitudinal studies have been done.METHODS: We performed diffusion weighted MRI twice, a year apart on 23 AD, 14 DLB, and 32 healthy control subjects. Mean diffusivity (MD) and fractional anisotropy (FA) were calculated.RESULTS: In AD, there were widespread regions where the longitudinal MD increase was greater than in controls, and small areas in the parietal and temporal lobes where it was greater in AD than DLB. In AD, decrease in brain volume correlated with increased MD. There were no significant differences in progression between DLB and controls.CONCLUSIONS: In AD the white matter continues to degenerate during the disease process, whereas in DLB, changes in the white matter structure are a relatively early feature. Different mechanisms are likely to underpin changes in diffusivity.

KW - Dementia with Lewy bodies

KW - Alzheimer's disease

KW - DWI

KW - MRI

U2 - 10.1016/j.parkreldis.2016.01.003

DO - 10.1016/j.parkreldis.2016.01.003

M3 - Article

C2 - 26792342

VL - 24

SP - 76

EP - 80

JO - Parkinsonism & Related Disorders

JF - Parkinsonism & Related Disorders

SN - 1353-8020

ER -