MacA, a diheme c-type cytochrome involved in Fe(III) reduction by Geobacter sulfurreducens

Jessica E Butler, Franz Kaufmann, Maddalena V Coppi, Cinthia Núñez, Derek R Lovley

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A 36-kDa diheme c-type cytochrome abundant in Fe(III)-respiring Geobacter sulfurreducens, designated MacA, was more highly expressed during growth with Fe(III) as the electron acceptor than with fumarate. Although MacA has homology to proteins with in vitro peroxidase activity, deletion of macA had no impact on response to oxidative stress. However, the capacity for Fe(III) reduction was greatly diminished, indicating that MacA, which is predicted to be localized in the periplasm, is a key intermediate in electron transfer to Fe(III).

Original languageEnglish
Pages (from-to)4042-5
Number of pages4
JournalJournal of Bacteriology
Issue number12
Publication statusPublished - Jun 2004



  • Amino Acid Sequence
  • Bacterial Proteins
  • Cytochrome c Group
  • Deltaproteobacteria
  • Electron Transport
  • Ferric Compounds
  • Gene Deletion
  • Molecular Sequence Data
  • Oxidation-Reduction

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