MacA, a diheme c-type cytochrome involved in Fe(III) reduction by Geobacter sulfurreducens

Jessica E Butler, Franz Kaufmann, Maddalena V Coppi, Cinthia Núñez, Derek R Lovley

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

A 36-kDa diheme c-type cytochrome abundant in Fe(III)-respiring Geobacter sulfurreducens, designated MacA, was more highly expressed during growth with Fe(III) as the electron acceptor than with fumarate. Although MacA has homology to proteins with in vitro peroxidase activity, deletion of macA had no impact on response to oxidative stress. However, the capacity for Fe(III) reduction was greatly diminished, indicating that MacA, which is predicted to be localized in the periplasm, is a key intermediate in electron transfer to Fe(III).

Original languageEnglish
Pages (from-to)4042-5
Number of pages4
JournalJournal of Bacteriology
Volume186
Issue number12
DOIs
Publication statusPublished - Jun 2004

Fingerprint

Lepidium
Geobacter
Electrons
Periplasm
Fumarates
Peroxidase
Oxidative Stress
diheme cytochrome c
Growth
Proteins

Keywords

  • Amino Acid Sequence
  • Bacterial Proteins
  • Cytochrome c Group
  • Deltaproteobacteria
  • Electron Transport
  • Ferric Compounds
  • Gene Deletion
  • Molecular Sequence Data
  • Oxidation-Reduction

Cite this

MacA, a diheme c-type cytochrome involved in Fe(III) reduction by Geobacter sulfurreducens. / Butler, Jessica E; Kaufmann, Franz; Coppi, Maddalena V; Núñez, Cinthia; Lovley, Derek R.

In: Journal of Bacteriology, Vol. 186, No. 12, 06.2004, p. 4042-5.

Research output: Contribution to journalArticle

Butler, Jessica E ; Kaufmann, Franz ; Coppi, Maddalena V ; Núñez, Cinthia ; Lovley, Derek R. / MacA, a diheme c-type cytochrome involved in Fe(III) reduction by Geobacter sulfurreducens. In: Journal of Bacteriology. 2004 ; Vol. 186, No. 12. pp. 4042-5.
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AU - Núñez, Cinthia

AU - Lovley, Derek R

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KW - Amino Acid Sequence

KW - Bacterial Proteins

KW - Cytochrome c Group

KW - Deltaproteobacteria

KW - Electron Transport

KW - Ferric Compounds

KW - Gene Deletion

KW - Molecular Sequence Data

KW - Oxidation-Reduction

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JO - Journal of Bacteriology

JF - Journal of Bacteriology

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