Macrophage heterogeneity in renal inflammation

Lars Peter Erwig, David C Kluth, Andrew J Rees

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Macrophages evolved to maintain and restore tissue integrity. They originate from bone marrow-derived precursors and traffic through tissues where they have essential roles in remodelling during fetal development; in host defence against infection and tumours; and in wound healing [1]. Macrophages also mediate injury in immune-mediated diseases including glomerulonephritis, and this aspect of their function together with their role in combating infection have tended to overshadow their involvement in tissue repair. Understanding how macrophage function adapts to the needs of particular microenvironments is a principal challenge for inflammatory cell biologists. Importantly, learning to manipulate macrophage function to promote their reparative properties would be a powerful therapeutic tool, a point emphasized by the recognition that many viruses, parasites and tumour cells have evolved to redirect macrophage function to promote their survival [2]. Our purpose here is to review briefly what is known about the role of macrophages in renal injury; to describe recent advances in understanding of macrophage activation; and to show that manipulation of macrophage function can have profound effects on the intensity of glomerular inflammation.
Original languageEnglish
Pages (from-to)1962-1965
Number of pages4
JournalNephrology Dialysis Transplantation
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 2003

Fingerprint

Macrophages
Inflammation
Kidney
Oncogenic Viruses
Macrophage Activation
Immune System Diseases
Wounds and Injuries
Glomerulonephritis
Fetal Development
Infection
Wound Healing
Parasites
Bone Marrow
Learning
Neoplasms
Therapeutics

Keywords

  • activation
  • inflammation
  • glomerulonephritis
  • macrophage

Cite this

Macrophage heterogeneity in renal inflammation. / Erwig, Lars Peter; Kluth, David C; Rees, Andrew J.

In: Nephrology Dialysis Transplantation, Vol. 18, No. 10, 10.2003, p. 1962-1965.

Research output: Contribution to journalArticle

Erwig, Lars Peter ; Kluth, David C ; Rees, Andrew J. / Macrophage heterogeneity in renal inflammation. In: Nephrology Dialysis Transplantation. 2003 ; Vol. 18, No. 10. pp. 1962-1965.
@article{688971f1afa34de4a5778cc2487c7ddf,
title = "Macrophage heterogeneity in renal inflammation",
abstract = "Macrophages evolved to maintain and restore tissue integrity. They originate from bone marrow-derived precursors and traffic through tissues where they have essential roles in remodelling during fetal development; in host defence against infection and tumours; and in wound healing [1]. Macrophages also mediate injury in immune-mediated diseases including glomerulonephritis, and this aspect of their function together with their role in combating infection have tended to overshadow their involvement in tissue repair. Understanding how macrophage function adapts to the needs of particular microenvironments is a principal challenge for inflammatory cell biologists. Importantly, learning to manipulate macrophage function to promote their reparative properties would be a powerful therapeutic tool, a point emphasized by the recognition that many viruses, parasites and tumour cells have evolved to redirect macrophage function to promote their survival [2]. Our purpose here is to review briefly what is known about the role of macrophages in renal injury; to describe recent advances in understanding of macrophage activation; and to show that manipulation of macrophage function can have profound effects on the intensity of glomerular inflammation.",
keywords = "activation, inflammation, glomerulonephritis, macrophage",
author = "Erwig, {Lars Peter} and Kluth, {David C} and Rees, {Andrew J}",
year = "2003",
month = "10",
doi = "10.1093/ndt/gfg313",
language = "English",
volume = "18",
pages = "1962--1965",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "OXFORD UNIV PRESS",
number = "10",

}

TY - JOUR

T1 - Macrophage heterogeneity in renal inflammation

AU - Erwig, Lars Peter

AU - Kluth, David C

AU - Rees, Andrew J

PY - 2003/10

Y1 - 2003/10

N2 - Macrophages evolved to maintain and restore tissue integrity. They originate from bone marrow-derived precursors and traffic through tissues where they have essential roles in remodelling during fetal development; in host defence against infection and tumours; and in wound healing [1]. Macrophages also mediate injury in immune-mediated diseases including glomerulonephritis, and this aspect of their function together with their role in combating infection have tended to overshadow their involvement in tissue repair. Understanding how macrophage function adapts to the needs of particular microenvironments is a principal challenge for inflammatory cell biologists. Importantly, learning to manipulate macrophage function to promote their reparative properties would be a powerful therapeutic tool, a point emphasized by the recognition that many viruses, parasites and tumour cells have evolved to redirect macrophage function to promote their survival [2]. Our purpose here is to review briefly what is known about the role of macrophages in renal injury; to describe recent advances in understanding of macrophage activation; and to show that manipulation of macrophage function can have profound effects on the intensity of glomerular inflammation.

AB - Macrophages evolved to maintain and restore tissue integrity. They originate from bone marrow-derived precursors and traffic through tissues where they have essential roles in remodelling during fetal development; in host defence against infection and tumours; and in wound healing [1]. Macrophages also mediate injury in immune-mediated diseases including glomerulonephritis, and this aspect of their function together with their role in combating infection have tended to overshadow their involvement in tissue repair. Understanding how macrophage function adapts to the needs of particular microenvironments is a principal challenge for inflammatory cell biologists. Importantly, learning to manipulate macrophage function to promote their reparative properties would be a powerful therapeutic tool, a point emphasized by the recognition that many viruses, parasites and tumour cells have evolved to redirect macrophage function to promote their survival [2]. Our purpose here is to review briefly what is known about the role of macrophages in renal injury; to describe recent advances in understanding of macrophage activation; and to show that manipulation of macrophage function can have profound effects on the intensity of glomerular inflammation.

KW - activation

KW - inflammation

KW - glomerulonephritis

KW - macrophage

U2 - 10.1093/ndt/gfg313

DO - 10.1093/ndt/gfg313

M3 - Article

VL - 18

SP - 1962

EP - 1965

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 10

ER -