Magnetizable needles and wires - modeling an efficient way to target magnetic microspheres in vivo

G. Iacob, Ovidiu Rotariu, Norval James Colin Strachan, U. O. Hafeli

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The in vivo targeting of tumors with magnetic microspheres is currently realized through the application of external non-uniform magnetic fields generated by rare-earth permanent magnets or electromagnets. Our theoretical work suggests a feasible procedure for local delivery of magnetic nano- and microparticles to a target area. In particular, thin magnetizable wires placed throughout or close to the target area and magnetized by a perpendicular external uniform background magnetic field are used to concentrate magnetic microspheres injected into the target organ's natural blood supply. The capture of the magnetic particles and the building of deposits thereof in the blood vessels of the target area were modeled under circumstances similar to the in vivo situation. This technique could be applied to magnetically targeted cancer therapy or magnetic embolization therapy with magnetic particles that contain anticancer agents, such as chemotherapeutic drugs or therapeutic radioisotopes.

Original languageEnglish
Pages (from-to)599-612
Number of pages13
JournalBiorheology
Volume41
Issue number5
Publication statusPublished - 2004

Keywords

  • magnetic targeting
  • ferromagnetic wires
  • magnetic capture
  • magnetic drug targeting
  • local radiotherapy
  • embolization
  • magnetic microspheres
  • magnetic nanospheres
  • SATURATION BUILDUP
  • SEPARATION
  • CONFIGURATION
  • PARTICLES
  • FILTERS
  • CAPTURE

Cite this

Magnetizable needles and wires - modeling an efficient way to target magnetic microspheres in vivo. / Iacob, G.; Rotariu, Ovidiu; Strachan, Norval James Colin; Hafeli, U. O.

In: Biorheology, Vol. 41, No. 5, 2004, p. 599-612.

Research output: Contribution to journalArticle

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