Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia

Abimbola A. Sowemimo, RuAngelie Edrada-Ebel, Rainer Ebel, Peter Proksch, Olanrewaju R. Omobuwajo, Saburi A. Adesanya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.

Original languageEnglish
Pages (from-to)1217-1222
Number of pages6
JournalNatural Product Communications
Volume3
Publication statusPublished - 2008

Keywords

  • endophytic fungi
  • diaporthe phaseolorum
  • neurospora discreta
  • aspergillus japonicus
  • microsphaerone C
  • cytotoxicity
  • marine-derived fungus
  • 4-hydroxyphenylacetic acid
  • diaporthe SP
  • metabolites
  • degradation
  • derivatives
  • continuum

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