Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia

Abimbola A. Sowemimo; RuAngelie Edrada-Ebel; Rainer Ebel; Peter Proksch; Olanrewaju R. Omobuwajo; Saburi A. Adesanya

doi:10.1177/1934578x0800300802

Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia

Abimbola A. Sowemimo, RuAngelie Edrada-Ebel, Rainer Ebel, Peter Proksch, Olanrewaju R. Omobuwajo, Saburi A. Adesanya

Chemistry

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.

Original language	English
Pages (from-to)	1217-1222
Number of pages	6
Journal	Natural Product Communications
Volume	3
DOIs	https://doi.org/10.1177/1934578x0800300802
Publication status	Published - 2008

Keywords

endophytic fungi
diaporthe phaseolorum
neurospora discreta
aspergillus japonicus
microsphaerone C
cytotoxicity
marine-derived fungus
4-hydroxyphenylacetic acid
diaporthe SP
metabolites
degradation
derivatives
continuum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1934578x0800300802

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title = "Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia",

abstract = "In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.",

keywords = "endophytic fungi, diaporthe phaseolorum, neurospora discreta, aspergillus japonicus, microsphaerone C, cytotoxicity, marine-derived fungus, 4-hydroxyphenylacetic acid, diaporthe SP, metabolites, degradation, derivatives, continuum",

author = "Sowemimo, {Abimbola A.} and RuAngelie Edrada-Ebel and Rainer Ebel and Peter Proksch and Omobuwajo, {Olanrewaju R.} and Adesanya, {Saburi A.}",

year = "2008",

doi = "10.1177/1934578x0800300802",

language = "English",

volume = "3",

pages = "1217--1222",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "Natural Product Communications",

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TY - JOUR

T1 - Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia

AU - Sowemimo, Abimbola A.

AU - Edrada-Ebel, RuAngelie

AU - Ebel, Rainer

AU - Proksch, Peter

AU - Omobuwajo, Olanrewaju R.

AU - Adesanya, Saburi A.

PY - 2008

Y1 - 2008

N2 - In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.

AB - In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.

KW - endophytic fungi

KW - diaporthe phaseolorum

KW - neurospora discreta

KW - aspergillus japonicus

KW - microsphaerone C

KW - cytotoxicity

KW - marine-derived fungus

KW - 4-hydroxyphenylacetic acid

KW - diaporthe SP

KW - metabolites

KW - degradation

KW - derivatives

KW - continuum

U2 - 10.1177/1934578x0800300802

DO - 10.1177/1934578x0800300802

M3 - Article

SN - 1934-578X

VL - 3

SP - 1217

EP - 1222

JO - Natural Product Communications

JF - Natural Product Communications

ER -

Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia

Abstract

Keywords

UN SDGs

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