Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia

Abimbola A. Sowemimo, RuAngelie Edrada-Ebel, Rainer Ebel, Peter Proksch, Olanrewaju R. Omobuwajo, Saburi A. Adesanya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.

Original languageEnglish
Pages (from-to)1217-1222
Number of pages6
JournalNatural Product Communications
Volume3
Publication statusPublished - 2008

Keywords

  • endophytic fungi
  • diaporthe phaseolorum
  • neurospora discreta
  • aspergillus japonicus
  • microsphaerone C
  • cytotoxicity
  • marine-derived fungus
  • 4-hydroxyphenylacetic acid
  • diaporthe SP
  • metabolites
  • degradation
  • derivatives
  • continuum

Cite this

Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia. / Sowemimo, Abimbola A.; Edrada-Ebel, RuAngelie; Ebel, Rainer; Proksch, Peter; Omobuwajo, Olanrewaju R.; Adesanya, Saburi A.

In: Natural Product Communications, Vol. 3, 2008, p. 1217-1222.

Research output: Contribution to journalArticle

Sowemimo, Abimbola A. ; Edrada-Ebel, RuAngelie ; Ebel, Rainer ; Proksch, Peter ; Omobuwajo, Olanrewaju R. ; Adesanya, Saburi A. / Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia. In: Natural Product Communications. 2008 ; Vol. 3. pp. 1217-1222.
@article{7aac35ae930c4b52a7c2f970dee9614d,
title = "Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia",
abstract = "In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.",
keywords = "endophytic fungi, diaporthe phaseolorum, neurospora discreta, aspergillus japonicus, microsphaerone C, cytotoxicity, marine-derived fungus, 4-hydroxyphenylacetic acid, diaporthe SP, metabolites, degradation, derivatives, continuum",
author = "Sowemimo, {Abimbola A.} and RuAngelie Edrada-Ebel and Rainer Ebel and Peter Proksch and Omobuwajo, {Olanrewaju R.} and Adesanya, {Saburi A.}",
year = "2008",
language = "English",
volume = "3",
pages = "1217--1222",
journal = "Natural Product Communications",
issn = "1934-578X",
publisher = "Natural Product Communications",

}

TY - JOUR

T1 - Major constituents of the predominant endophytic fungi from the Nigerian plants Bryophyllum pinnatum, Morinda lucida and Jathropha gossypiifolia

AU - Sowemimo, Abimbola A.

AU - Edrada-Ebel, RuAngelie

AU - Ebel, Rainer

AU - Proksch, Peter

AU - Omobuwajo, Olanrewaju R.

AU - Adesanya, Saburi A.

PY - 2008

Y1 - 2008

N2 - In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.

AB - In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong, activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.

KW - endophytic fungi

KW - diaporthe phaseolorum

KW - neurospora discreta

KW - aspergillus japonicus

KW - microsphaerone C

KW - cytotoxicity

KW - marine-derived fungus

KW - 4-hydroxyphenylacetic acid

KW - diaporthe SP

KW - metabolites

KW - degradation

KW - derivatives

KW - continuum

M3 - Article

VL - 3

SP - 1217

EP - 1222

JO - Natural Product Communications

JF - Natural Product Communications

SN - 1934-578X

ER -