Male breast carcinoma: increased awareness needed

Jonathan White, Olive Kearins, David Dodwell, Kieran Horgan, Andrew M Hanby, Valerie Speirs (Corresponding Author)

Research output: Contribution to journalReview article

63 Citations (Scopus)

Abstract

Male breast carcinoma is a rare condition. Few male breast cancer-specific epidemiological or clinical trial data are available - our understanding of male breast cancer thus comes from studies of female breast cancer, painting an inaccurate picture when it comes to determining contributing factors. Clinicians report an increase in diagnoses of male breast cancer but this has not been formally reported. We therefore undertook a review of data obtained from four western nations: England, Scotland, Canada and Australia. When adjusted for age, this review clearly showed an increase in the incidence of male breast cancer over a 15-year period. Reasons for the increased incidence are discussed in the context of suggested risk factors such as BRCA2 and lifestyle changes over the past few decades. The clinical management of male breast carcinoma is considered, in particular the potential role of aromatase inhibitors and fulvestrant and targeting pathways involving prolactin and androgen receptor.

Original languageEnglish
Article number219
JournalBreast Cancer Research
Volume13
DOIs
Publication statusPublished - 29 Sep 2011

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Keywords

  • Australia
  • BRCA2 Protein
  • Breast Neoplasms, Male
  • Canada
  • England
  • Health Knowledge, Attitudes, Practice
  • Humans
  • Life Style
  • Male
  • Risk Factors
  • Scotland
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Cite this

White, J., Kearins, O., Dodwell, D., Horgan, K., Hanby, A. M., & Speirs, V. (2011). Male breast carcinoma: increased awareness needed. Breast Cancer Research, 13, [219]. https://doi.org/10.1186/bcr2930