TY - JOUR
T1 - Management of early pregnancy loss
AU - Graziosi, G. C.M.
AU - Mol, B. W.
AU - Ankum, W. M.
AU - Bruinse, H. W.
PY - 2004/9
Y1 - 2004/9
N2 - Objectives: In order to assess the available evidence on the management of early pregnancy loss, we performed a meta-analysis on the subject. Methods: MEDLINE and EMBASE were searched for randomized studies reporting on the effectiveness of expectant management, misoprostol treatment or curettage. Outcomes considered were 'complete evacuation', complications, duration of bleeding, pain resulting from the procedure, side effects and women's satisfaction with the procedure. Results: Thirteen studies were identified. Combined data in women with missed abortion managed expectantly or treated with misoprostol showed complete evacuation rates of 28% (49/173) (range 14-47%) and 81% (242/298) (range 60-83%), respectively. In women with incomplete abortion, these rates were 94% (31/33) (range 80-100%) and 99% (75/76) (range 99-100%), respectively. Conclusion: In the management of early pregnancy loss both expectant management and misoprostol treatment reduce the need for curettage, but misoprostol treatment seems to be more effective in women with missed abortion as compared to expectant management.
AB - Objectives: In order to assess the available evidence on the management of early pregnancy loss, we performed a meta-analysis on the subject. Methods: MEDLINE and EMBASE were searched for randomized studies reporting on the effectiveness of expectant management, misoprostol treatment or curettage. Outcomes considered were 'complete evacuation', complications, duration of bleeding, pain resulting from the procedure, side effects and women's satisfaction with the procedure. Results: Thirteen studies were identified. Combined data in women with missed abortion managed expectantly or treated with misoprostol showed complete evacuation rates of 28% (49/173) (range 14-47%) and 81% (242/298) (range 60-83%), respectively. In women with incomplete abortion, these rates were 94% (31/33) (range 80-100%) and 99% (75/76) (range 99-100%), respectively. Conclusion: In the management of early pregnancy loss both expectant management and misoprostol treatment reduce the need for curettage, but misoprostol treatment seems to be more effective in women with missed abortion as compared to expectant management.
KW - Curettage
KW - Early pregnancy loss
KW - Expectant management
KW - Meta-analysis
KW - Misoprostol
UR - http://www.scopus.com/inward/record.url?scp=4344638314&partnerID=8YFLogxK
U2 - 10.1016/j.ijgo.2004.04.038
DO - 10.1016/j.ijgo.2004.04.038
M3 - Review article
C2 - 15325850
AN - SCOPUS:4344638314
VL - 86
SP - 337
EP - 346
JO - International Journal of Gynecology & Obstetrics
JF - International Journal of Gynecology & Obstetrics
SN - 0020-7292
IS - 3
ER -