Comparison of clinical baseline characteristics between Asian and Western COPD patients in a prospective, international, multicenter study

Kyu Yean Kim, Marc Miravitlles, Pawel Sliwinski, Richard Costello, Victoria Carter, Jessica Tan, Therese Sophie Lapperre, Bernardino Alcazar, Caroline Gouder, Cristina Esquinas, Juan Luis García-Rivero, Anu Kemppinen, Augustine Tee, Miguel Roman-Rodríguez, Juan José Soler-Cataluña, David Price, Chin Kook Rhee

Research output: Contribution to journalArticle

Abstract

We aimed to compare clinical characteristics between Asian and Western chronic obstructive pulmonary disease (COPD) patients. This was a sub-analysis of an international, multicenter, prospective cohort study. Asian patients were enrolled in Singapore and South Korea. Western patients were enrolled in Spain, Poland, Ireland, the United Kingdom, and Malta. A total of 349 patients were analyzed. Among them, 110 (32%) patients were Asian and 239 (68%) Western. Male sex was more predominant in Asian than in Western (95% versus 63%, respectively; P<0.01). Body mass index was significantly lower in Asian (23.5 versus 27.1; P<0.01). The proportion of patients with a history of exacerbation was lower in Asian (12% versus 64%; P<0.01). Although patients were enrolled by same inclusion criteria, there were several differences between Asian and Western COPD patients. Our study has shown unbiased real-world differences between Asian and Western COPD patients. Since prospective follow-up study is currently ongoing, the result of this study can be fundamental base of future analysis.

Original languageEnglish
Pages (from-to)1595-1601
Number of pages7
JournalInternational journal of chronic obstructive pulmonary disease
Volume14
DOIs
Publication statusPublished - 25 Jul 2019

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Chronic Obstructive Pulmonary Disease
Multicenter Studies
Malta
Republic of Korea
Singapore
Poland
Ireland
Spain
Body Mass Index
Cohort Studies
Prospective Studies

Keywords

  • COPD
  • Asian
  • Western

Cite this

Comparison of clinical baseline characteristics between Asian and Western COPD patients in a prospective, international, multicenter study. / Kim, Kyu Yean; Miravitlles, Marc; Sliwinski, Pawel; Costello, Richard; Carter, Victoria; Tan, Jessica; Lapperre, Therese Sophie; Alcazar, Bernardino; Gouder, Caroline; Esquinas, Cristina; García-Rivero, Juan Luis; Kemppinen, Anu; Tee, Augustine; Roman-Rodríguez, Miguel; Soler-Cataluña, Juan José; Price, David; Rhee, Chin Kook.

In: International journal of chronic obstructive pulmonary disease , Vol. 14, 25.07.2019, p. 1595-1601.

Research output: Contribution to journalArticle

Kim, KY, Miravitlles, M, Sliwinski, P, Costello, R, Carter, V, Tan, J, Lapperre, TS, Alcazar, B, Gouder, C, Esquinas, C, García-Rivero, JL, Kemppinen, A, Tee, A, Roman-Rodríguez, M, Soler-Cataluña, JJ, Price, D & Rhee, CK 2019, 'Comparison of clinical baseline characteristics between Asian and Western COPD patients in a prospective, international, multicenter study', International journal of chronic obstructive pulmonary disease , vol. 14, pp. 1595-1601. https://doi.org/10.2147/COPD.S208245
Kim, Kyu Yean ; Miravitlles, Marc ; Sliwinski, Pawel ; Costello, Richard ; Carter, Victoria ; Tan, Jessica ; Lapperre, Therese Sophie ; Alcazar, Bernardino ; Gouder, Caroline ; Esquinas, Cristina ; García-Rivero, Juan Luis ; Kemppinen, Anu ; Tee, Augustine ; Roman-Rodríguez, Miguel ; Soler-Cataluña, Juan José ; Price, David ; Rhee, Chin Kook. / Comparison of clinical baseline characteristics between Asian and Western COPD patients in a prospective, international, multicenter study. In: International journal of chronic obstructive pulmonary disease . 2019 ; Vol. 14. pp. 1595-1601.
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note = "The study was designed and coordinated by the Respiratory Effectiveness Group (REG; www.effectivenessevaluation.org; Cambridge, UK) and delivered by Optimum Patient Care (OPC; www.optimumpatientcare.org). The following investigators participated in the study: Spain: Marc Miravitlles, Cristina Esquinas, Miriam Barrecheguren, Alexa Nu{\~n}ez, Hospital Universitari Vall d’Hebron, Barcelona. Bernardino Alcazar, Hospital de Alta Resoluci{\'o}n de Loja. Juan Luis Garc{\'i}a-Rivero, Karina Hueso, Hospital Comarcal de Laredo, Cantabria. Miguel Roman-Rodr{\'i}guez, Primary Health-care Center Son Pis{\`a}. IB-Salut. Palma de Mallorca. Poland: Pawel Sliwinsk Sliwinski, Katarzyna Iwan, Jacek Kolakowski, Institute of Tuberculosis and Lung Diseases, Warsaw. Korea: Chin Kook Rhee, Esther Ahn, St Mary’s Hospital. Seoul. Singapore: Jessica Tan, Therese Lapperre, Karen Tan Li Leng, Nicole Chia, Ong Thun How, Syifa Binte Shamsuddin, Sherine Lim Shu Gim, Yap Chwee Bee, Soh Rui Ya, Singapore General Hospital. Augustine Tee, Jun Jie Yan, Samuel Hong, William Tan, Jessica Tan, Changi General Hospital. UK: Victoria Carter, Latife Hardaker, Andrew McLaughlin, Optimum Patient Care, Cambridge. Malta: Caroline Gouder, Mater Dei Hospital. Ireland: Richard W Costello, Royal College of Surgeons. Dublin. The study was funded by an unrestricted grant from Novartis AG.",
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T1 - Comparison of clinical baseline characteristics between Asian and Western COPD patients in a prospective, international, multicenter study

AU - Kim, Kyu Yean

AU - Miravitlles, Marc

AU - Sliwinski, Pawel

AU - Costello, Richard

AU - Carter, Victoria

AU - Tan, Jessica

AU - Lapperre, Therese Sophie

AU - Alcazar, Bernardino

AU - Gouder, Caroline

AU - Esquinas, Cristina

AU - García-Rivero, Juan Luis

AU - Kemppinen, Anu

AU - Tee, Augustine

AU - Roman-Rodríguez, Miguel

AU - Soler-Cataluña, Juan José

AU - Price, David

AU - Rhee, Chin Kook

N1 - The study was designed and coordinated by the Respiratory Effectiveness Group (REG; www.effectivenessevaluation.org; Cambridge, UK) and delivered by Optimum Patient Care (OPC; www.optimumpatientcare.org). The following investigators participated in the study: Spain: Marc Miravitlles, Cristina Esquinas, Miriam Barrecheguren, Alexa Nuñez, Hospital Universitari Vall d’Hebron, Barcelona. Bernardino Alcazar, Hospital de Alta Resolución de Loja. Juan Luis García-Rivero, Karina Hueso, Hospital Comarcal de Laredo, Cantabria. Miguel Roman-Rodríguez, Primary Health-care Center Son Pisà. IB-Salut. Palma de Mallorca. Poland: Pawel Sliwinsk Sliwinski, Katarzyna Iwan, Jacek Kolakowski, Institute of Tuberculosis and Lung Diseases, Warsaw. Korea: Chin Kook Rhee, Esther Ahn, St Mary’s Hospital. Seoul. Singapore: Jessica Tan, Therese Lapperre, Karen Tan Li Leng, Nicole Chia, Ong Thun How, Syifa Binte Shamsuddin, Sherine Lim Shu Gim, Yap Chwee Bee, Soh Rui Ya, Singapore General Hospital. Augustine Tee, Jun Jie Yan, Samuel Hong, William Tan, Jessica Tan, Changi General Hospital. UK: Victoria Carter, Latife Hardaker, Andrew McLaughlin, Optimum Patient Care, Cambridge. Malta: Caroline Gouder, Mater Dei Hospital. Ireland: Richard W Costello, Royal College of Surgeons. Dublin. The study was funded by an unrestricted grant from Novartis AG.

PY - 2019/7/25

Y1 - 2019/7/25

N2 - We aimed to compare clinical characteristics between Asian and Western chronic obstructive pulmonary disease (COPD) patients. This was a sub-analysis of an international, multicenter, prospective cohort study. Asian patients were enrolled in Singapore and South Korea. Western patients were enrolled in Spain, Poland, Ireland, the United Kingdom, and Malta. A total of 349 patients were analyzed. Among them, 110 (32%) patients were Asian and 239 (68%) Western. Male sex was more predominant in Asian than in Western (95% versus 63%, respectively; P<0.01). Body mass index was significantly lower in Asian (23.5 versus 27.1; P<0.01). The proportion of patients with a history of exacerbation was lower in Asian (12% versus 64%; P<0.01). Although patients were enrolled by same inclusion criteria, there were several differences between Asian and Western COPD patients. Our study has shown unbiased real-world differences between Asian and Western COPD patients. Since prospective follow-up study is currently ongoing, the result of this study can be fundamental base of future analysis.

AB - We aimed to compare clinical characteristics between Asian and Western chronic obstructive pulmonary disease (COPD) patients. This was a sub-analysis of an international, multicenter, prospective cohort study. Asian patients were enrolled in Singapore and South Korea. Western patients were enrolled in Spain, Poland, Ireland, the United Kingdom, and Malta. A total of 349 patients were analyzed. Among them, 110 (32%) patients were Asian and 239 (68%) Western. Male sex was more predominant in Asian than in Western (95% versus 63%, respectively; P<0.01). Body mass index was significantly lower in Asian (23.5 versus 27.1; P<0.01). The proportion of patients with a history of exacerbation was lower in Asian (12% versus 64%; P<0.01). Although patients were enrolled by same inclusion criteria, there were several differences between Asian and Western COPD patients. Our study has shown unbiased real-world differences between Asian and Western COPD patients. Since prospective follow-up study is currently ongoing, the result of this study can be fundamental base of future analysis.

KW - COPD

KW - Asian

KW - Western

U2 - 10.2147/COPD.S208245

DO - 10.2147/COPD.S208245

M3 - Article

VL - 14

SP - 1595

EP - 1601

JO - International journal of chronic obstructive pulmonary disease

JF - International journal of chronic obstructive pulmonary disease

SN - 1176-9106

ER -