Mannosylation in Candida albicans: role in cell wall function and immune recognition

Rebecca A. Hall, Neil A. R. Gow

Research output: Contribution to journalArticle

88 Citations (Scopus)
3 Downloads (Pure)

Abstract

The fungal cell wall is a dynamic organelle required for cell shape, protection against the environment and, in pathogenic species, recognition by the innate immune system. The outer layer of the cell wall is comprised of glycosylated mannoproteins with the majority of these post-translational modifications being the addition of O- and N-linked mannosides. These polysaccharides are exposed on the outer surface of the fungal cell wall and are, therefore, the first point of contact between the fungus and the host immune system. This review focuses on O- and N-linked mannan biosynthesis in the fungal pathogen Candida albicans and highlights new insights gained from the characterization of mannosylation mutants into the role of these cell wall components in host–fungus interactions. In addition, we discuss the use of fungal mannan as a diagnostic marker of fungal disease.
Original languageEnglish
Pages (from-to)1147-1161
Number of pages15
JournalMolecular Microbiology
Volume90
Issue number6
Early online date8 Nov 2013
DOIs
Publication statusPublished - Dec 2013

    Fingerprint

Cite this