Marine metabolites and metal ion chelation

Stephen H. Wright*, Andrea Raab, Jörg Feldmann, Eva Krupp, Marcel Jaspars

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)


This chapter covers the unique ability of marine invertebrates to bioconcentrate transition metals by up to 8 orders of magnitude above background concentrations. A brief introduction deals with the bioinorganic principles of the subject matter and the natural concentrations of metals in the environment. Next, previous metal surveys of marine invertebrates and the potential reasons for hyperaccumulation are discussed, and this is followed by a section on previously isolated marine natural product-transition metal complexes. Studies on marine natural product complexation using physical methods are described in the context of their binding specificity and affinity. Many of these studies were conducted to try and discover potential functions for the marine natural product-transition metal complexes. Methodological aspects to discover new complexes of this type are discussed, especially hyphenated techniques utilizing elemental and molecular mass spectrometric methods. A final section proposes a rational way to uncover new marine natural product-transition metal complexes and potential methods to determine their function in nature.

Original languageEnglish
Title of host publicationHandbook of Marine Natural Products
PublisherSpringer Netherlands
Number of pages32
ISBN (Electronic)9789048138340
ISBN (Print)9789048138333
Publication statusPublished - 8 Mar 2012


  • metal complex
  • inductively coupled mass spectrometry
  • marine natural product


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