Marine natural products targeting phospholipases A2

Florence Folmer, Marcel Jaspars, Marc Schumacher, Mario Dicato, Marc Diederich*

*Corresponding author for this work

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Phospholipases A2 (PLA2s) form a family of enzymes catalyzing the hydrolysis of membrane phospholipids into arachidonic acid, which is the major precursor of pro-inflammatory eicosanoids. As a result, PLA2s have been considered as potential targets in anti-inflammatory drug discovery.Marine natural products are a rich source of bioactive compounds, including PLA2 inhibitors. Here, we review the properties of marine PLA2 inhibitors identified since the first discovery of PLA2 inhibitory activity in the marine natural product manoalide in the mid 1980s.

Original languageEnglish
Pages (from-to)1793-1800
Number of pages8
JournalBIOCHEMICAL PHARMACOLOGY
Volume80
Issue number12
DOIs
Publication statusPublished - 15 Dec 2010

Keywords

  • Anti-inflammatory
  • Arachidonic acid
  • Eicosanoids
  • Marine natural product
  • Membrane phospholipids
  • PLA

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    Folmer, F., Jaspars, M., Schumacher, M., Dicato, M., & Diederich, M. (2010). Marine natural products targeting phospholipases A2. BIOCHEMICAL PHARMACOLOGY, 80(12), 1793-1800. https://doi.org/10.1016/j.bcp.2010.08.024