Abstract
Phospholipases A2 (PLA2s) form a family of enzymes catalyzing the hydrolysis of membrane phospholipids into arachidonic acid, which is the major precursor of pro-inflammatory eicosanoids. As a result, PLA2s have been considered as potential targets in anti-inflammatory drug discovery.Marine natural products are a rich source of bioactive compounds, including PLA2 inhibitors. Here, we review the properties of marine PLA2 inhibitors identified since the first discovery of PLA2 inhibitory activity in the marine natural product manoalide in the mid 1980s.
Original language | English |
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Pages (from-to) | 1793-1800 |
Number of pages | 8 |
Journal | BIOCHEMICAL PHARMACOLOGY |
Volume | 80 |
Issue number | 12 |
DOIs | |
Publication status | Published - 15 Dec 2010 |
Keywords
- Anti-inflammatory
- Arachidonic acid
- Eicosanoids
- Marine natural product
- Membrane phospholipids
- PLA