Markers of oxidative stress, skeletal muscle mass and function, and their responses to resistance exercise training in older adults

Ciriaco Carru, Mariasole Da Boit, Panagiotis Paliogiannis, Angelo Zinellu, Salvatore Sotgia, Rachael Sibson, Judith R. Meakin, Richard M. Aspden, Arduino A. Mangoni, Stuart R. Gray

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Abstract

BACKGROUND: Oxidative stress (OS) negatively affects skeletal muscle homeostasis in experimental models of ageing. However, little is known about the associations between circulating OS markers and parameters of muscle mass and function, and their responses to exercise training, in humans.

METHODS: Maximal voluntary contraction (MVC, primary outcome) and isokinetic torque of the knee extensors at 30° s-1 (MIT), muscle cross-sectional area (MCSA) and quality (MQ, secondary outcomes), and plasma concentrations of malondialdehyde (MDA, pro-OS), homocysteine (HCY, pro-OS), taurine (TAU, anti-OS), and protein sulphydryl groups (PSH, anti-OS) were measured in 27 healthy older males and 23 females at baseline and after an 18-week resistance exercise program, with or without a nutritional intervention (fish oil vs. placebo).

RESULTS: After adjusting for age, glomerular filtration rate, and nutritional intervention, there were no significant correlations between baseline OS markers and muscle parameters, barring a positive association between TAU and MIT in females (r = 0.53, P = .035) and between MDA and MCSA in males (r = 0.69, P = .001). Training did not significantly change OS markers, except for a reduction in MDA in females (-0.27 μmol/L, 95% CI -0.51 to -0.02, P = .034). In females, there were significant correlations between baseline MDA and exercise-induced changes in MVC (P = .018), baseline TAU and changes in MCSA (P = .026), and baseline HCY and changes in MCSA (P = .046) and MQ (P = .022). In males, baseline MDA was significantly associated with exercise-induced changes in MVC (P = .040).

CONCLUSIONS: Plasma MDA, HCY, and TAU were significantly associated with baseline and/or exercise-induced changes in muscle mass and function in healthy older adults, primarily in females. Pending further confirmation in other populations, specific OS markers, particularly MDA, might predict muscle responses to resistance exercise programs in old age.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalExperimental Gerontology
Volume103
Early online date9 Jan 2018
DOIs
Publication statusPublished - Mar 2018

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Oxidative stress
Resistance Training
Muscle
Skeletal Muscle
Oxidative Stress
Exercise
Muscles
Plasmas
Fish Oils
Taurine
Torque
Homocysteine
Heat-Shock Proteins
Malondialdehyde
Glomerular Filtration Rate
Knee
Homeostasis
Theoretical Models
Aging of materials
Placebos

Keywords

  • Journal Article
  • oxidative stress
  • muscle mass
  • muscle function
  • old age
  • exercise

Cite this

Markers of oxidative stress, skeletal muscle mass and function, and their responses to resistance exercise training in older adults. / Carru, Ciriaco; Da Boit, Mariasole; Paliogiannis, Panagiotis; Zinellu, Angelo; Sotgia, Salvatore; Sibson, Rachael; Meakin, Judith R.; Aspden, Richard M.; Mangoni, Arduino A.; Gray, Stuart R.

In: Experimental Gerontology, Vol. 103, 03.2018, p. 101-106.

Research output: Contribution to journalArticle

Carru, C, Da Boit, M, Paliogiannis, P, Zinellu, A, Sotgia, S, Sibson, R, Meakin, JR, Aspden, RM, Mangoni, AA & Gray, SR 2018, 'Markers of oxidative stress, skeletal muscle mass and function, and their responses to resistance exercise training in older adults' Experimental Gerontology, vol. 103, pp. 101-106. https://doi.org/10.1016/j.exger.2017.12.024
Carru, Ciriaco ; Da Boit, Mariasole ; Paliogiannis, Panagiotis ; Zinellu, Angelo ; Sotgia, Salvatore ; Sibson, Rachael ; Meakin, Judith R. ; Aspden, Richard M. ; Mangoni, Arduino A. ; Gray, Stuart R. / Markers of oxidative stress, skeletal muscle mass and function, and their responses to resistance exercise training in older adults. In: Experimental Gerontology. 2018 ; Vol. 103. pp. 101-106.
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abstract = "BACKGROUND: Oxidative stress (OS) negatively affects skeletal muscle homeostasis in experimental models of ageing. However, little is known about the associations between circulating OS markers and parameters of muscle mass and function, and their responses to exercise training, in humans.METHODS: Maximal voluntary contraction (MVC, primary outcome) and isokinetic torque of the knee extensors at 30° s-1 (MIT), muscle cross-sectional area (MCSA) and quality (MQ, secondary outcomes), and plasma concentrations of malondialdehyde (MDA, pro-OS), homocysteine (HCY, pro-OS), taurine (TAU, anti-OS), and protein sulphydryl groups (PSH, anti-OS) were measured in 27 healthy older males and 23 females at baseline and after an 18-week resistance exercise program, with or without a nutritional intervention (fish oil vs. placebo).RESULTS: After adjusting for age, glomerular filtration rate, and nutritional intervention, there were no significant correlations between baseline OS markers and muscle parameters, barring a positive association between TAU and MIT in females (r = 0.53, P = .035) and between MDA and MCSA in males (r = 0.69, P = .001). Training did not significantly change OS markers, except for a reduction in MDA in females (-0.27 μmol/L, 95{\%} CI -0.51 to -0.02, P = .034). In females, there were significant correlations between baseline MDA and exercise-induced changes in MVC (P = .018), baseline TAU and changes in MCSA (P = .026), and baseline HCY and changes in MCSA (P = .046) and MQ (P = .022). In males, baseline MDA was significantly associated with exercise-induced changes in MVC (P = .040).CONCLUSIONS: Plasma MDA, HCY, and TAU were significantly associated with baseline and/or exercise-induced changes in muscle mass and function in healthy older adults, primarily in females. Pending further confirmation in other populations, specific OS markers, particularly MDA, might predict muscle responses to resistance exercise programs in old age.",
keywords = "Journal Article, oxidative stress, muscle mass, muscle function, old age, exercise",
author = "Ciriaco Carru and {Da Boit}, Mariasole and Panagiotis Paliogiannis and Angelo Zinellu and Salvatore Sotgia and Rachael Sibson and Meakin, {Judith R.} and Aspden, {Richard M.} and Mangoni, {Arduino A.} and Gray, {Stuart R.}",
note = "Acknowledgments Professor Arduino A. Mangoni contributed to this study during a Visiting Professorship at the University of Sassari. Funding: this work was supported by the Biotechnology and Biological Sciences Research Council, United Kingdom (grant number BB/J015911/1).",
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T1 - Markers of oxidative stress, skeletal muscle mass and function, and their responses to resistance exercise training in older adults

AU - Carru, Ciriaco

AU - Da Boit, Mariasole

AU - Paliogiannis, Panagiotis

AU - Zinellu, Angelo

AU - Sotgia, Salvatore

AU - Sibson, Rachael

AU - Meakin, Judith R.

AU - Aspden, Richard M.

AU - Mangoni, Arduino A.

AU - Gray, Stuart R.

N1 - Acknowledgments Professor Arduino A. Mangoni contributed to this study during a Visiting Professorship at the University of Sassari. Funding: this work was supported by the Biotechnology and Biological Sciences Research Council, United Kingdom (grant number BB/J015911/1).

PY - 2018/3

Y1 - 2018/3

N2 - BACKGROUND: Oxidative stress (OS) negatively affects skeletal muscle homeostasis in experimental models of ageing. However, little is known about the associations between circulating OS markers and parameters of muscle mass and function, and their responses to exercise training, in humans.METHODS: Maximal voluntary contraction (MVC, primary outcome) and isokinetic torque of the knee extensors at 30° s-1 (MIT), muscle cross-sectional area (MCSA) and quality (MQ, secondary outcomes), and plasma concentrations of malondialdehyde (MDA, pro-OS), homocysteine (HCY, pro-OS), taurine (TAU, anti-OS), and protein sulphydryl groups (PSH, anti-OS) were measured in 27 healthy older males and 23 females at baseline and after an 18-week resistance exercise program, with or without a nutritional intervention (fish oil vs. placebo).RESULTS: After adjusting for age, glomerular filtration rate, and nutritional intervention, there were no significant correlations between baseline OS markers and muscle parameters, barring a positive association between TAU and MIT in females (r = 0.53, P = .035) and between MDA and MCSA in males (r = 0.69, P = .001). Training did not significantly change OS markers, except for a reduction in MDA in females (-0.27 μmol/L, 95% CI -0.51 to -0.02, P = .034). In females, there were significant correlations between baseline MDA and exercise-induced changes in MVC (P = .018), baseline TAU and changes in MCSA (P = .026), and baseline HCY and changes in MCSA (P = .046) and MQ (P = .022). In males, baseline MDA was significantly associated with exercise-induced changes in MVC (P = .040).CONCLUSIONS: Plasma MDA, HCY, and TAU were significantly associated with baseline and/or exercise-induced changes in muscle mass and function in healthy older adults, primarily in females. Pending further confirmation in other populations, specific OS markers, particularly MDA, might predict muscle responses to resistance exercise programs in old age.

AB - BACKGROUND: Oxidative stress (OS) negatively affects skeletal muscle homeostasis in experimental models of ageing. However, little is known about the associations between circulating OS markers and parameters of muscle mass and function, and their responses to exercise training, in humans.METHODS: Maximal voluntary contraction (MVC, primary outcome) and isokinetic torque of the knee extensors at 30° s-1 (MIT), muscle cross-sectional area (MCSA) and quality (MQ, secondary outcomes), and plasma concentrations of malondialdehyde (MDA, pro-OS), homocysteine (HCY, pro-OS), taurine (TAU, anti-OS), and protein sulphydryl groups (PSH, anti-OS) were measured in 27 healthy older males and 23 females at baseline and after an 18-week resistance exercise program, with or without a nutritional intervention (fish oil vs. placebo).RESULTS: After adjusting for age, glomerular filtration rate, and nutritional intervention, there were no significant correlations between baseline OS markers and muscle parameters, barring a positive association between TAU and MIT in females (r = 0.53, P = .035) and between MDA and MCSA in males (r = 0.69, P = .001). Training did not significantly change OS markers, except for a reduction in MDA in females (-0.27 μmol/L, 95% CI -0.51 to -0.02, P = .034). In females, there were significant correlations between baseline MDA and exercise-induced changes in MVC (P = .018), baseline TAU and changes in MCSA (P = .026), and baseline HCY and changes in MCSA (P = .046) and MQ (P = .022). In males, baseline MDA was significantly associated with exercise-induced changes in MVC (P = .040).CONCLUSIONS: Plasma MDA, HCY, and TAU were significantly associated with baseline and/or exercise-induced changes in muscle mass and function in healthy older adults, primarily in females. Pending further confirmation in other populations, specific OS markers, particularly MDA, might predict muscle responses to resistance exercise programs in old age.

KW - Journal Article

KW - oxidative stress

KW - muscle mass

KW - muscle function

KW - old age

KW - exercise

U2 - 10.1016/j.exger.2017.12.024

DO - 10.1016/j.exger.2017.12.024

M3 - Article

VL - 103

SP - 101

EP - 106

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

ER -