Abstract
Network-centered studies in systems biology attempt to integrate the topological properties of biological networks with experimental data in order to make predictions and posit hypotheses. For any topology-based prediction, it is necessary to first assess the significance of the analyzed property in a biologically meaningful context. Therefore, devising network null models, carefully tailored to the topological and biochemical constraints imposed on the network, remains an important computational problem.
Original language | English |
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Pages (from-to) | 1397-1403 |
Number of pages | 7 |
Journal | Bioinformatics |
Volume | 27 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2011 |