Mass-balanced randomization of metabolic networks

Georg Basler, Oliver Ebenhöh, Joachim Selbig, Zoran Nikoloski

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Network-centered studies in systems biology attempt to integrate the topological properties of biological networks with experimental data in order to make predictions and posit hypotheses. For any topology-based prediction, it is necessary to first assess the significance of the analyzed property in a biologically meaningful context. Therefore, devising network null models, carefully tailored to the topological and biochemical constraints imposed on the network, remains an important computational problem.
Original languageEnglish
Pages (from-to)1397-1403
Number of pages7
JournalBioinformatics
Volume27
Issue number10
DOIs
Publication statusPublished - 2011

Fingerprint

Systems Biology
Metabolic Network
Random Allocation
Randomisation
Metabolic Networks and Pathways
Prediction
Biological Networks
Topology
Topological Properties
Null
Integrate
Experimental Data
Necessary
Model

Cite this

Basler, G., Ebenhöh, O., Selbig, J., & Nikoloski, Z. (2011). Mass-balanced randomization of metabolic networks. Bioinformatics, 27(10), 1397-1403. https://doi.org/10.1093/bioinformatics/btr145

Mass-balanced randomization of metabolic networks. / Basler, Georg; Ebenhöh, Oliver; Selbig, Joachim; Nikoloski, Zoran.

In: Bioinformatics, Vol. 27, No. 10, 2011, p. 1397-1403.

Research output: Contribution to journalArticle

Basler, G, Ebenhöh, O, Selbig, J & Nikoloski, Z 2011, 'Mass-balanced randomization of metabolic networks', Bioinformatics, vol. 27, no. 10, pp. 1397-1403. https://doi.org/10.1093/bioinformatics/btr145
Basler G, Ebenhöh O, Selbig J, Nikoloski Z. Mass-balanced randomization of metabolic networks. Bioinformatics. 2011;27(10):1397-1403. https://doi.org/10.1093/bioinformatics/btr145
Basler, Georg ; Ebenhöh, Oliver ; Selbig, Joachim ; Nikoloski, Zoran. / Mass-balanced randomization of metabolic networks. In: Bioinformatics. 2011 ; Vol. 27, No. 10. pp. 1397-1403.
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