Mass-balanced randomization of metabolic networks

Georg Basler, Oliver Ebenhöh, Joachim Selbig, Zoran Nikoloski

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Network-centered studies in systems biology attempt to integrate the topological properties of biological networks with experimental data in order to make predictions and posit hypotheses. For any topology-based prediction, it is necessary to first assess the significance of the analyzed property in a biologically meaningful context. Therefore, devising network null models, carefully tailored to the topological and biochemical constraints imposed on the network, remains an important computational problem.
Original languageEnglish
Pages (from-to)1397-1403
Number of pages7
JournalBioinformatics
Volume27
Issue number10
DOIs
Publication statusPublished - 2011

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