Maternal and fetal tissue accumulation of selected endocrine disrupting compounds (EDCs) following exposure to sewage sludge-treated pastures before or after conception

S M Rhind, C E Kyle, C C MacKie, L McDonald, Z Zhang, E I Duff, M Bellingham, M R Amezaga, B Mandon-Pepin, B Loup, C Cotinot, N P Evans, R M Sharpe, P A F Fowler

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Abstract

Liver concentrations of selected pollutant classes were determined in groups of sheep fetuses and their dams, at 55 (Experiment 1) and 110 (Experiment 2) days of gestation (term = 145 d) following exposure, throughout their breeding lives and after mating, to pasture treated with either inorganic fertiliser (control, CC) or with sewage sludge (treated, TT). In a unique study designed to separate the respective contributions of environmental sources and mobilised tissue to the available EDC burden, in additional groups of animals, pollutant burdens at 110 days gestation were assessed following exposure to the respective treatments, either throughout their breeding lives until mating, but not thereafter (TC), or only between mating and slaughter (CT) (Experiment 3). With very few exceptions, maternal and fetal liver concentrations of diethylhexyl phthalate (DEHP) and selected polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDE) and polycyclic aromatic hydrocarbons (PAHs) were not significantly affected by sludge exposure in any group. In some cases, maternal and fetal tissue EDC concentrations were different but the differences were not consistent, and maternal and fetal concentrations of none of the classes of chemical were significantly correlated. It was not possible to identify a single chemical, or class of chemical, that may be responsible for previously observed physiological effects of exposure to sludge-treated pastures. It is concluded that exposure of sheep to pastures fertilised with sewage sludge was not associated with increased liver concentrations of EDCs, irrespective of the stage of development at which they were measured and of maternal tissue mobilisation and EDC release during gestation. Thus, retrospective measurements of EDC tissue burdens could not be used to accurately assess earlier fetal EDC insults.
Original languageEnglish
Pages (from-to)1582-1593
Number of pages12
JournalJournal of Environmental Monitoring
Volume12
Issue number8
Early online date30 Jul 2010
DOIs
Publication statusPublished - Aug 2010

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Sewage
pasture
Fetus
Mothers
pregnancy
sheep
Pregnancy
Breeding
sludge
breeding
Liver
Sheep
Diethylhexyl Phthalate
Halogenated Diphenyl Ethers
pollutant
experiment
PBDE
phthalate
Polychlorinated Biphenyls
Polycyclic Aromatic Hydrocarbons

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Maternal and fetal tissue accumulation of selected endocrine disrupting compounds (EDCs) following exposure to sewage sludge-treated pastures before or after conception. / Rhind, S M; Kyle, C E; MacKie, C C; McDonald, L; Zhang, Z; Duff, E I; Bellingham, M; Amezaga, M R; Mandon-Pepin, B; Loup, B; Cotinot, C; Evans, N P; Sharpe, R M; Fowler, P A F.

In: Journal of Environmental Monitoring, Vol. 12, No. 8, 08.2010, p. 1582-1593.

Research output: Contribution to journalArticle

Rhind, SM, Kyle, CE, MacKie, CC, McDonald, L, Zhang, Z, Duff, EI, Bellingham, M, Amezaga, MR, Mandon-Pepin, B, Loup, B, Cotinot, C, Evans, NP, Sharpe, RM & Fowler, PAF 2010, 'Maternal and fetal tissue accumulation of selected endocrine disrupting compounds (EDCs) following exposure to sewage sludge-treated pastures before or after conception', Journal of Environmental Monitoring, vol. 12, no. 8, pp. 1582-1593. https://doi.org/10.1039/c0em00009d
Rhind, S M ; Kyle, C E ; MacKie, C C ; McDonald, L ; Zhang, Z ; Duff, E I ; Bellingham, M ; Amezaga, M R ; Mandon-Pepin, B ; Loup, B ; Cotinot, C ; Evans, N P ; Sharpe, R M ; Fowler, P A F. / Maternal and fetal tissue accumulation of selected endocrine disrupting compounds (EDCs) following exposure to sewage sludge-treated pastures before or after conception. In: Journal of Environmental Monitoring. 2010 ; Vol. 12, No. 8. pp. 1582-1593.
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AU - Zhang, Z

AU - Duff, E I

AU - Bellingham, M

AU - Amezaga, M R

AU - Mandon-Pepin, B

AU - Loup, B

AU - Cotinot, C

AU - Evans, N P

AU - Sharpe, R M

AU - Fowler, P A F

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N2 - Liver concentrations of selected pollutant classes were determined in groups of sheep fetuses and their dams, at 55 (Experiment 1) and 110 (Experiment 2) days of gestation (term = 145 d) following exposure, throughout their breeding lives and after mating, to pasture treated with either inorganic fertiliser (control, CC) or with sewage sludge (treated, TT). In a unique study designed to separate the respective contributions of environmental sources and mobilised tissue to the available EDC burden, in additional groups of animals, pollutant burdens at 110 days gestation were assessed following exposure to the respective treatments, either throughout their breeding lives until mating, but not thereafter (TC), or only between mating and slaughter (CT) (Experiment 3). With very few exceptions, maternal and fetal liver concentrations of diethylhexyl phthalate (DEHP) and selected polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDE) and polycyclic aromatic hydrocarbons (PAHs) were not significantly affected by sludge exposure in any group. In some cases, maternal and fetal tissue EDC concentrations were different but the differences were not consistent, and maternal and fetal concentrations of none of the classes of chemical were significantly correlated. It was not possible to identify a single chemical, or class of chemical, that may be responsible for previously observed physiological effects of exposure to sludge-treated pastures. It is concluded that exposure of sheep to pastures fertilised with sewage sludge was not associated with increased liver concentrations of EDCs, irrespective of the stage of development at which they were measured and of maternal tissue mobilisation and EDC release during gestation. Thus, retrospective measurements of EDC tissue burdens could not be used to accurately assess earlier fetal EDC insults.

AB - Liver concentrations of selected pollutant classes were determined in groups of sheep fetuses and their dams, at 55 (Experiment 1) and 110 (Experiment 2) days of gestation (term = 145 d) following exposure, throughout their breeding lives and after mating, to pasture treated with either inorganic fertiliser (control, CC) or with sewage sludge (treated, TT). In a unique study designed to separate the respective contributions of environmental sources and mobilised tissue to the available EDC burden, in additional groups of animals, pollutant burdens at 110 days gestation were assessed following exposure to the respective treatments, either throughout their breeding lives until mating, but not thereafter (TC), or only between mating and slaughter (CT) (Experiment 3). With very few exceptions, maternal and fetal liver concentrations of diethylhexyl phthalate (DEHP) and selected polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDE) and polycyclic aromatic hydrocarbons (PAHs) were not significantly affected by sludge exposure in any group. In some cases, maternal and fetal tissue EDC concentrations were different but the differences were not consistent, and maternal and fetal concentrations of none of the classes of chemical were significantly correlated. It was not possible to identify a single chemical, or class of chemical, that may be responsible for previously observed physiological effects of exposure to sludge-treated pastures. It is concluded that exposure of sheep to pastures fertilised with sewage sludge was not associated with increased liver concentrations of EDCs, irrespective of the stage of development at which they were measured and of maternal tissue mobilisation and EDC release during gestation. Thus, retrospective measurements of EDC tissue burdens could not be used to accurately assess earlier fetal EDC insults.

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